• 沈彬(Bin Shen)

    南京医科大学生殖医学国家重点实验室

    研究员、博士生导师

    Email:binshen@njmu.edu.cn

    、教育背景及工作经历

    2014至今 南京医科大学生殖医学国家重点实验室,研究员,博士生导师

    2008-2014 南京大学 生物学博士

    2004-2008 兰州大学 生命科学学院 本科

    二、主要研究方向

    1. RNA表观修饰在配子发生和胚胎发育中的作用
    2. 基因编辑和治疗

    三、获奖情况

    1. 2017 优秀青年科学基金
    2. 2016 江苏省杰出青年科学基金
    3. 2015 江苏省优秀博士毕业论文
    4. 2014 南京大学优秀毕业生
    5. 2014 南京大学拔尖计划A
    6. 2012 The Wellcome Trust奖学金
    7. 2011 南京大学优秀研究生
    8. 2010 南京大学优秀研究生奖学金
    9. 2007 兰州大学奖学金
    10. 2006 兰州大学奖学金
    11. 2005 兰州大学奖学金

    四、代表性论文

    1. Zhang T, Chen P, Li W, Sha S, Wang Y, Yuan Z, Shen B#, Chen L#. Cognitive deficits in mice lacking Nsun5, a cytosine-5 RNA methyltransferase, with impairment of oligodendrocyte precursor cells. Glia. 2018 Nov 28. doi: 10.1002/glia.23565.
    2. Wang H, Zuo H, Liu J, Wen F, Gao Y, Zhu X, Liu B, Xiao F, Wang W, Huang G, Shen B # , Ju Z#. Loss of YTHDF2-mediated m6A-dependent mRNA clearance facilitates hematopoietic stem cell regeneration. Cell Res. 2018 Agu;28(10):1035–1038.
    3.  Lei L, Chen H, Xue W, Yang B, Hu B, Wei J, Wang L, Cui Y, Li W, Wang J, Yan L, Shang W, Sha J, Zhuang M, Huang X, Shen B # , Yang L#, Chen J # . APOBEC3 induces mutations during repair of CRISPR-Cas9-generated DNA breaks. Nat Struct Mol Biol. 2018 Jan;25(1):45-52.
    4.  Roundtree IA, Luo GZ, Zhang Z, Wang X, Zhou T, Cui Y, Sha J, Huang X, Guerrero L, Xie P, He E, Shen B # , He C # . YTHDC1 Mediates Nuclear Export of N6-methyladenosine Methylated m RNAs. Elife. 2017 Oct 6;6. pii: e31311.
    5.  Hsu PJ, Zhu Y, Ma H, Guo Y, Shi X, Liu Y, Qi M, Lu Z, Shi H, Wang J, Cheng Y, Luo G, Dai Q, Liu M, Guo X, Sha J, Shen B # , He C # . Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesis. Cell Res. 2017 Sep;27(9):1115-1127.
    6.   Hu X, Shen B*, Liao S, Ning Y, Ma L, Chen J, Lin X, Zhang D, Li Z, Zheng C, Feng Y, Huang X, Han C. Gene knockout of Zmym3 in mice arrests spermatogenesis at meiotic metaphase with defects in spindle assembly checkpoint. Cell Death Dis. 2017 Jun 29;8(6):e2910.
    7.  Kang Y*, Zheng B*, Shen B*, Chen Y*, Wang L*, Wang J, Niu Y, Cui Y, Zhou J, Wang H, Guo X, Hu B, Zhou Q, Sha J, Ji W, Huang X. CRISPR/Cas9-mediated Dax1 knockout in the monkey recapitulates human AHC-HH. Hum Mol Genet. 2015 Dec 20;24(25):7255-64.
    8.  Yuan Y*, Zhou Q*, Wan H*, Shen B*, Wang X, Wang M, Feng C, Xie M, Gu T, Zhou T, Fu R, Huang X, Zhou Q, Sha J, Zhang XY. Generation of fertile offspring from Kitw/Kitwv mice through differentiation of gene corrected nuclear transfer embryonic stem cells. Cell Res. 2015 Jul;25(7):851-63
    9.   Iyer V*, Shen B*, Zhang W, Hodgkins A, Keane T, Huang X, Skarnes WC. Off-target mutations are rare in Cas9-modified mice. Nat Methods. 2015 May 28;12(6):479.
    10.  Chen Y*, Cui Y*, Shen B*, Niu Y*, Zhao X, Wang L, Wang J, Zhou Q, Ji W, Sha J, Huang X. Germline acquisition of Cas9/RNA-mediated gene modifications in monkeys. Cell Res. 2015 Feb;25(2):262-5.
    11. Shen B*, Zhang W*, Zhang J*, Zhou J, Wang J, Chen L, Wang L, Hodgkins A, Iyer V, Huang X, Skarnes WC. Efficient genome modification by CRISPR-Cas9 nickase with minimal off- target effects. Nat Methods. 2014 Apr;11(4):399-402.
    12. Shen B*, Shang Z*, Wang B*, Zhang L*, Zhou F*, Li T, Chu M, Jiang H, Wang Y, Qiao T, Zhang J, Sun W, Kong X, He Y. Genetic dissection of TIE pathway in lymphatic maturation and valve development. Arterioscler Thromb Vasc Biol. 2014 Jun;34(6):1221-30.
    13.  Niu Y*, Shen B*, Cui Y*, Chen Y*, Wang J, Wang L, Kang Y, Zhao X, Si W, Xiang P, Zhou J, Huang X, Ji W, Sha J. Generation of gene-modified cynomolgus monkey via Cas9/RNA- mediated gene targeting in one-cell embryos. Cell. 2014 Feb 13;156(4):836-43. (Selected by Nature as one of the events in the years in sciences: Wins and Losses) (Selected by Cell as one of the 10 Best articles in 2014).
    14. Shen B*, Zhang J*, Wu H*, Wang J, Ma K, Li Z, Zhang X, Zhang P, Huang X. Generation of gene-modified mice via Cas9/RNA-mediated gene targeting. Cell Res. 2013 May;23(5):720-3.
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