• 王华林 (Hualin Wang)

    博士,研究人员,讲师

    Ph.D

    一、教育背景及工作经历(Education and Work Experience)

    2019年8月至今:昆明理工大学灵长类转化医学研究院,讲师

    2018年1月—2019年7月:美国加州大学圣地亚哥分校医学院,博士后

    2014年9月—2017年11月:法国国家健康与医学研究院,获巴黎第六大学(今索邦大学)博士学位

    2011年9月—2014年7月:中国科学院大学,获理学硕士学位

    2007年9月—2011年7月:西南大学生命科学学院,获学士学位

     

    • Aug 2010 – present, Assistant Researcher

    Yunnan Key Laboratory of Primate Biomedical Research (LPBR), Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming, China.

    • Jan 2018 – Jul. 2019, Postdoctoral Fellow in the Cancer Biology Program.

    School of Medicine, University of California San Diego (UCSD), San Diego, USA.

    • Sep. 2014 – Nov. 2017, Ph.D candidate in Biochemistry and Molecular Biology.

    School of Medicine, University Pierre and Marie Curie (UPMC) & French National Institute of Health and Medical Research (INSERM), Paris, France.

    • Sep. 2011 – Jul. 2014, Graduate study in Genetics.

    Institute of Hydrobiology, Chinese Academy of Sciences (CAS), Wuhan, China.

    • Sep. 2007 – Jul. 2011, Undergraduate study in Bioengineering.

    School of Life Sciences, Southwest University, Chongqing, China.

    二、主要研究方向(Research Interests)

    1. mRNA可变剪接与肝脏疾病
    2. 人类疾病的灵长类动物模型建立和细胞/基因治疗

    三、承担科研项目情况(Research Projects and Grants)

    1. 2018/01-2019/07 美国NIH R01项目(#R01CA188506),主要参与人
    2. 2015/06-2017/11 法国Fondation Arc Recherche Sur le Cancer项目(#M17JRAS009),主要参与人
    3. 2014/09-2017/11 法国ANRS项目(#ECTZ22204),主要参与人
    4. 2011/09-2014/07 国家重点基础研究发展计划(973计划)项目(#2010CB126306),参与

    四、代表性论文和专著(Publications)

    1. Hualin Wang, Bouchra Lekbaby, Nadim Fares, Jeremy Augustin, Tarik Attout, Aurelie Schnuriger, Anne-Marie Cassard-Doulcier, Ganna Panasyuk, Gabriel Perlemuter, Ivan Bieche, Sophie Vacher, Janick Selves, Jean-Marie Péron, Brigitte Bancel, Philippe Merle, Dina Kremsdorf, Janet Hall, Isabelle Chemin, Patrick Soussan (2019). Alteration of splicing factors’ expression during liver disease progression: impact on hepatocellular carcinoma outcome. Hepatology International 13(4), 454-467.
    2. Khaliq Mehwish, Ko Sungjin, Liu Yinzi, Wang Hualin, Sun Yonghua, Solnica-Krezel Lila, Shin Donghun (2018). Stat3 regulates liver progenitor cell-driven liver regeneration in zebrafish. Gene Expr 18(3), 157-170.
    3. Marion Duriez*, Yassmina Mandouri*, Bouchra Lekbaby, Hualin Wang, Aurelie Schnuriger, Francois Redelsperger, Chiara Ida Guerrera, Marine Lefevre, Veronique Fauveau, James Ahodantin, Ivan Quetier, Cerina Chhuon, Samir Gourari, Alexandre Boissonnas, Upkar Gill, Patrick Kennedy, Nabil Debzi, Delphine Sitterlin, Mala K. Maini, Dina Kremsdorf, Patrick Soussan (2017). Alternative splicing of hepatitis B virus: A novel virus/host interaction altering liver immunity. Journal of Hepatology 67, 687-699.
    4. Ziru Dai*, Hualin Wang*, Xia Jin, Houpeng Wang, Jiangyan He, Mugen Liu, Zhan Yin, Yonghua Sun, Qiyong Lou (2015). Depletion of suppressor of cytokine signaling-1a causes hepatic steatosis and insulin resistance in zebrafish. Am J Physiol Endocrinol Metab 308, 849-859. (* co-first authors)
    5. Mudan He, Fenghua Zhang, Hualin Wang, Houpeng Wang, Zuoyan Zhu, Yonghua Sun (2015). Efficient ligase 3-dependent microhomology-mediated end joining repair of DNA double-strand breaks in zebrafish embryos. Mutation Research 780, 86-96.
    6. Hualin Wang, Zuoyan Zhu, Yonghua Sun (2015). TALEN-mediated knock out of zebrafish socs2 and the growth performance of socs2 mutants. Acta Hydrobiologica Sinica 39(4), 831-836.
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