• 王强(Qiang Wang)

    南京医科大学生殖医学国家重点实验室
    教授

    、教育经历

    2004/09 – 2007/07,中国科学院动物研究所,博士,导师:孙青原研究员

    2001/09 – 2004/07,西北农林科技大学,动物医学院,硕士,导师:张涌教授

    1997/09 – 2001/07,西北农林科技大学,动物医学院,学士

    二、工作经历

    2012/09 –目前,南京医科大学,生殖医学国家重点实验室,教授

    2007/08 –2012/09,美国华盛顿大学医学院,妇产科系/遗传学系,博士后 导师: Kelle Moley 教授和 Tim Schedl 教授

    三、承担科研项目情况

    1.  国家重点研发计划,2018YFC1004000,植入前胚胎发育的调控网络研究,2018.12- 2021.12,192 万元,学术骨干
    2. 江苏省杰出青年基金项目,BK20180035,母源营养影响卵母细胞质量及胚胎发育的分子 基础,2018.07-2021.06,100 万元,主持
    3.  国家自然科学基金面上项目,31771657,Nampt 在小鼠卵母细胞发育过程中的作用及机 制研究,2018.01-2021.12,60 万元,主持
    4.  国家重点研发计划项目,2017YFC1001500,卵母细胞体外成熟的机制与临床应用研究, 2017.07-2020.1,96.5 万元,课题组长
    5.  国家自然科学基金面上项目,31571543,Sirt2 在小鼠卵母细胞发育和老化过程中的作 用及机制研究,2016.01-2019.12,78 万元,主持
    6.   国家重大基础研究计划,2014CB943200,决定卵母细胞质量的分子机制,2014.01- 2018.08,220 万元,学术骨干
    7.   国家自然科学基金青年科学基金项目,31301181,卵子母源效应在肥胖诱发出生缺陷过 程中的作用,2014.01-2016.12,23.00 万元,主持
    8.   国家自然科学基金面上项目,31271541,丙酮酸脱氢酶在母源糖尿病对卵子质量影响过 程中的作用,2013.01-2016.12,75 万元,主持

    四、获奖情况

    2018 年: 江苏省“333 高层次人才培养工程”培养对象

    2014 年: 南京医科大学校特聘教授

    五、代表性论文

    1.  Han L, Ren C, Zhang J, Shu W, Wang Q*. Differential roles of Stella in the modulation of DNA methylation during oocyte and zygotic development. Cell Discov. 2019 Jan 29. ( *通 讯作者)
    2.   Hou X, Zhu S, Zhang H, Li C, Qiu D, Ge J, Guo X, Wang Q*. Mitofusin1 in oocyte is essential for female fertility. Redox Biol. 2019 Feb;21:101110.( *通 讯作者)   
    3.  Li C, Diao F, Qiu D, Jiang M, Li X, Han L, Li L, Hou X, Ge J, Ou X, Liu J, Wang Q*. Histone methyltransferase SETD2 is required for meiotic maturation in mouse oocyte. J Cell Physiol. 2018 Jan;234(1):661-668. ( *通 讯作者)
    4.   Zeng J, Jiang M, Wu X, Diao F, Qiu D, Hou X, Wang H, Li L, Li C, Ge J, Liu J, Ou X, Wang Q*. SIRT4 is essential for metabolic control and meiotic structure during mouse oocyte maturation. Aging Cell. 2018 May 29. ( *通 讯作者)
    5.   Wang H, Cheng Q, Li X, Hu F, Han L, Zhang H, Li L, Ge J, Ying X, Guo X, Wang Q*. Loss of TIGAR Induces Oxidative Stress and Meiotic Defects in Oocytes from Obese Mice. Mol Cell Proteomics. 2018 Jul;17(7):1354-1364. ( *通 讯作者)
    6.   Han L, Ren C, Li L, Li X, Ge J, Wang H, Miao YL, Guo X, Moley KH, Shu W*, Wang Q*. Embryonic defects induced by maternal obesity in mice derive from Stella insufficiency in oocytes. Nat Genet. 2018 Mar;50(3): 432-442. ( *通 讯作者)
    7.   Qiu D, Hou X, Han L, Li X, Ge J, Wang Q * . Sirt2-Bub R1 acetylation pathway mediates the effects of advanced maternal age on oocyte quality. Aging Cell. 2017 Oct 25. ( *通 讯作者)
    8.   Liu X, Zhang L, Wang P, Li X, Qiu D, Li L, Zhang J, Hou X, Han L, Ge J, Li M, Gu L, Wang Q * . Sirt3- dependent deacetylation of SOD2 plays a protective role against oxidative stress in oocytesfrom diabetic mice. Cell Cycle. 2017 Jul 3;16(13):1302-1308. ( *通 讯作者)
    9.  Han L, Wang H, Li L, Li X, Ge J, Reiter RJ, Wang Q * . Melatonin protects against maternal obesity-associated oxidative stress and meiotic defects inoocytes via the SIRT3-SOD2- dependent pathway. J Pineal Res. 2017 Oct;63(3). ( *通 讯作者)
    10.  Zhang J, Ma R, Li L, Wang L, Hou X, Han L, Ge J, Li M, Wang Q * . Intersectin 2 controls actin cap formation and meiotic division in mouse oocytes through the Cdc42 pathway. FASEB J. 2017 Oct;31(10):4277-4285. ( *通 讯作者)
    11.   Ling L, Hu F, Ying X, Ge J, Wang Q * . HDAC6 inhibition disrupts maturational progression and meiotic apparatus assembly in mouseoocytes. Cell Cycle. 2017 Jun 9:0. ( *通 讯作者)
    12.   Hou X, Zhang L, Han L, Ge J, Ma R, Zhang X, Moley K, Schedl T, Wang Q*. Differing roles of pyruvate dehydrogenase kinases during mouse oocyte maturation. J Cell Sci. 2015 Jul 1;128(13):2319-29.( *通 讯作者)
    13.   Zhang L, Han L, Ma R, Hou X, Yu Y, Sun S, Xu Y, Schedl T, Moley KH, Wang Q*. Sirt3 prevents maternal obesity-associated oxidative stress and meiotic defects in mouse oocytes. Cell Cycle. 2015;14(18):2959-68.( *通 讯作者)
    14.   Gu L, Liu H, Gu X, Boots C, Moley KH, Wang Q*. Metabolic control of oocyte development: linking maternal nutrition and reproductive outcomes. Cell Mol Life Sci. 2015 Jan;72(2):251-71. (* 通讯作者)
    15.   Ma R, Hou X, Zhang L, Sun SC, Schedl T, Moley K, Wang Q*. Rab5a is required for spindle length control and kinetochore-microtubule attachment during meiosis inoocytes. FASEB J. 2014 Sep;28(9):4026-35.( *通 讯作者)
    16.  Zhang L, Hou X, Ma R, Moley K, Schedl T, Wang Q*. Sirt2 functions in spindle organization and chromosome alignment in mouse oocyte meiosis. FASEB J. 2014 Mar;28(3):1435-45.( *通 讯 作者)
    17.  Luzzo KM, Wang Q # , Purcell SH, Chi M, Jimenez PT, Grindler N, Schedl T, Moley KH*. High fat diet induced developmental defects in the mouse: oocyte meiotic aneuploidy and fetal growth retardation/brain defects. PLo S One. 2012;7(11):e49217. ( #并 列一作)
    18. Wang Q, Chi MM, Schedl T, Moley KH. An intercellular pathway for glucose transport into mouse oocytes. Am J Physiol Endocrinol Metab. 2012 Jun 15;302(12):E1511-8
    19.   Wang Q, Chi MM, Moley KH*. Live imaging reveals the link between decreased glucose uptake in ovarian cumulus cells and impaired oocyte quality in female diabetic mice. Endocrinology. 2012 Apr;153(4):1984-9.
    20.   Wang Q, Frolova AI, Purcell S, Adastra K, Schoeller E, Chi MM, Schedl T, Moley KH*. Mitochondrial dysfunction and apoptosis in cumulus cells of type I diabetic mice. PLo S One. 2010 28;5(12):e15901.
    21.   Wang Q, Moley KH. Maternal diabetes and oocyte quality. Mitochondrion. 2010 10(5):403-10.  
    22.   Wang Q, Ratchford AM, Chi MM, Schoeller E, Frolova A, Schedl T, Moley KH*. Maternal diabetes causes mitochondrial dysfunction and meiotic defects in murine oocytes. Molecular Endocrinology. 2009 23(10):1603-12. Featured article by Endocrine News.
    23.  Wang Q, Ai JS, Idowu Ola S, Gu L, Zhang YZ, Chen DY, Sun QY*. The spatial relationship between heterochromatin protein 1 alpha and histone modifications during mouse oocyte meiosis. Cell Cycle. 2008 15;7(4):513-20.
    24.  Wang Q, Sun QY*. Evaluation of oocyte quality: morphological, cellular and molecular predictors. Reproduction, Fertility and Development. 2007;19(1):1-12.
    25.   Wang Q, Wang CM, Ai JS, Xiong B, Yin S, Hou Y, Chen DY, Schatten H, Sun QY*. Histone phosphorylation and pericentromeric histone modifications in oocyte meiosis. Cell Cycle. 2006 5(17):1974-82.
    26.   Wang Q, Yin S, Ai JS, Liang CG, Hou Y, Chen DY, Schatten H, Sun QY*. Histone deacetylation is required for orderly meiosis. Cell Cycle. 2006 5(7):766-74.  
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