• 王正波 (Zhengbo Wang)

    博士、副教授
    硕士研究生导师

    一、教育经历

    2004.9-2007.6:甘肃农业大学动物医学院,基础兽医学,获得农学博士学位

    2001.9-2004.6:甘肃农业大学动物医学院,基础兽医学,获得农学硕士学位

    1997.9-2001.6:湖北农学院动物科学系,农学学士

    二、工作经历

    2018.8至今:昆明理工大学灵长类转化医学研究院,副教授

    2017.1-2018.8:中科院昆明动物研究所,副研究员

    2010.10-2016.12:中科院昆明动物研究所,助理研究员

    2007.8-2010.9:中国科学院动物模型与人类疾病机理重点实验室,博士后,神经生物学,合作导师:胡新天研究员

    三、主要研究方向

    1. 猕猴退行性神经系统疾病模型的构建

    2. 猕猴神经干细胞定向分化及移植研究

    四、科研领域描述

    长期从事神经干细胞定向诱导分化后猕猴脑内移植的研究;现正在开展非人灵长类猕猴神经退行性疾病模型的建立及干细胞移植治疗研究。

    五、承担科研项目情况

    1.云南省自然科学基金面上项目,2018FB052,猕猴黑质神经干细胞移植存活、分化及投射研究,2018.1-2021.12,10万,在研,主持

    2. 973项目,2015CB755605,灵长类模型神经回路成像研究,2015.1-2019.8,349.4万,在研,子课题组长

    六、代表性论文和专著

    Huang B(#), Wu S(#), Wang Z(#), Ge L, Rizak JD, Wu J, Li J, Xu L, Lv L(*), Yin Y(*), Hu X(*), Li H(*). Phosphorylated α-Synuclein Accumulations and Lewy Body-like Pathology Distributed in Parkinson's Disease-Related Brain Areas of Aged Rhesus Monkeys Treated with MPTP. Neuroscience. 2018 May 21;379:302-315.

     

    Liu S(#), Wang Z(#), Chen D(#), Zhang B(#), Tian RR(#), Wu J, Zhang Y, Xu K, Yang LM, Cheng C, Ma J, Lv L, Zheng YT, Hu X, Zhang Y(*), Wang X(*), Li J(*). Annotation and cluster analysis of spatiotemporal- and sex-related lncRNA expression in rhesus macaque brain. Genome Res. 2017 Sep;27(9):1608-1620.

     

    Wang ZB(#), Qin DD(#), Hu XT. Engrafted newborn neurons could functionally integrate into the host neuronal network. Zool Res. 2017 Jan 18;38(1):5-6.

     

    Huma T(*), Hu X, Ma Y, Willden A, Rizak J, Shahab M, Wang Z(*). Kisspeptin-10 treatment generated specific GnRH expression in cells differentiated from rhesus monkey derived Lyon NSCs. Neuroscience. 2017 May 4;349:318-329.

     

    Wei JK(#), Wang WC(#), Zhai RW(#), Zhang YH, Yang SC, Rizak J, Li L, Xu LQ, Liu L, Pan MK, Hu YZ, Ghanemi A, Wu J, Yang LC, Li H, Lv LB, Li JL, Yao YG, Xu L, Feng XL, Yin Y, Qin DD, Hu XT(*), Wang ZB(*). Neurons Differentiated from Transplanted Stem Cells Respond Functionally to Acoustic Stimuli in the Awake Monkey Brain. Cell Rep. 2016 Jul 26;16(4):1016-1025.

     

    Li H(#) ,Lei X(#) ,Yan T (#),Li H,Huang B,Li L,Xu L,Liu L,Chen N,Lü L,Ma Y,Xu L,Li J,Wang Z(*),Zhang B(*),Hu X(*),The temporary and accumulated effects of transcranial direct current stimulation for the treatment of advanced Parkinson's disease monkeys,Sci Rep,2015,5:12178.

     

    Ye L, Zhao H, Zhou H, Ren X, Liu L,Newton O.Otecko, Wang Z, Yang M, Zeng L, Hu X, Yao Y, Zhang Y, Wu D. The RNA editome of Macaca mulatta and functional characterization of RNA editing in mitochondria. Science Bulletin Volume 62, Issue 12, 30 June 2017, Pages 820-830

     

    He X, Li Z, Rizak JD, Wu S, Wang Z, He R, Su M, Qin D, Wang J, Hu X. Resveratrol Attenuates Formaldehyde Induced Hyperphosphorylation of Tau Protein and Cytotoxicity in N2a Cells. Front Neurosci. 2017 Jan 31;10:598.

     

    Ye L, Bian H, Fan Y, Wang Z, Yu H, Ma Y, Chen F. Rhesus monkey neural stem cell transplantation promotes neural regeneration in rats with hippocampal lesions. Neural Regen Res. 2016 Sep;11(9):1464-1470.

     

    Yang W, Wang G, Wang CE, Guo X, Yin P, Gao J, Tu Z, Wang Z, Wu J, Hu X, Li S, Li XJ. Mutant alpha-synuclein causes age-dependent neuropathology in monkey brain. J Neurosci. 2015 May 27;35(21):8345-58.

     

    Lei X, Li H, Huang B, Rizak J, Li L, Xu L, Liu L, Wu J, Lü L, Wang Z, Hu Y, Le W, Deng X, Li J, Yao Y, Xu L, Hu X, Zhang B. 1-methyl-4-phenylpyridinium stereotactic infusion completely and specifically ablated the nigrostriatal dopaminergic pathway in rhesus macaque. PLoS One. 2015 May 26;10(5):e0127953.

     

    Li H, Lei X, Huang B, Rizak JD, Yang L, Yang S, Wu J, Lü L, Wang J, Yan T, Li H, Wang Z, Hu Y, Le W, Deng X, Li J, Xu L, Zhang B, Hu X. A quantitative approach to developing Parkinsonian monkeys (Macaca fascicularis) with intracerebroventricular 1-methyl-4-phenylpyridinium injections. J Neurosci Methods. 2015 Aug 15;251:99-107.

     

    Yang M, Miao J, Rizak J, Zhai R, Wang Z, Huma T, Li T, Zheng N, Wu S, Zheng Y, Fan X, Yang J, Wang J, Yang S, Ma Y, Lü L, He R, Hu X. Alzheimer's disease and methanol toxicity (part 2): lessons from four rhesus macaques (Macaca mulatta) chronically fed methanol. J Alzheimers Dis. 2014;41(4):1131-47.

     

    Huma T, Wang Z, Rizak J, Ahmad F, Shahab M, Ma Y, Yang S, Hu X. Kisspeptin-10 modulates the proliferation and differentiation of the rhesus monkey derived stem cell line: r366.4. Scientific World Journal. 2013 Nov 28;2013:135470

     

    Wu J, Wang W, Rizak JD, Wang Z, Wang J, Feng X, Dong J, Li L, Liu L, Xu L, Yang S, Hu X. A new method for piercing the tentorium cerebelli for implanting fragile electrodes into the brain stem in the rhesus monkey (Macaca mulatta). J Neurophysiol. 2013 Dec 11.

     

    Chen Y, Wang Z, Xie Y, Guo X, Tang X, Wang S, Yang S, Chen K, Niu Y, Ji W. Folic acid deficiency inhibits neural rosette formation and neuronal differentiation from rhesus monkey embryonic stem cells. J Neurosci Res. 2012 Jul;90(7):1382-91.

     

    Ni J, Jiang H, Jin Y, Chen N, Wang J, Wang Z, Luo Y, Ma Y, Hu X. Dissociable modulation of overt visual attention in valence and arousal revealed by topology of scan path. PLoS One. 2011 Apr 6;6(4):e18262.

     

    Guo L, Wei J, Yang S, Wang Z(*). Glaucoma model for stem cell transplantation research in New Zealand white rabbits.Dongwuxue Yanjiu. 2012 Apr;33(2):225-30. doi: 10.3724/SP.J.1141.2012.02225. Chinese.

     

    Dong J, Guo L, Qu J, Qi R, Wang W, Xiao C(*), Wang Z(*). Rhesus monkey embryonic stem cells differentiation, proliferation and allotransplantation. Dongwuxue Yanjiu. 2012 Feb;33(1):43-8. doi: 10.3724/SP.J.1141.2012.01043. Chinese.

     

    Yang S, Dong J, Qu J, Hu X, Wang Z(*). A traumatic brain injury model for distinguishing between transplanted neural cells and host cells in vivo. Dongwuxue Yanjiu. 2011 Aug;32(4):421-7. doi: 10.3724/SP.J.1141.2011.04421. Chinese.

    七、授权发明专利

    1. 杨上川,张玉华,胡新天,王正波,胡英周,用于磁共振的大动物头部固定装置(申请号: 201320520310.7),中国, ZL 201320520310.7。

    2. 杨上川,胡新天,王正波,吴晶,双向微电极推进器及微电极(申请号:201320190992.X),中国, ZL 201320190992.X。

    3. 杨上川,胡新天,王正波,胡英周,用于大动物立体定位仪的耳杆高度可调耳杆座(申请号:201320175021.8),中国, ZL 201320175021.8.

    4. 杨上川,胡新天,王正波,王文超,马原野脑微量组织取样器(申请号:201210110829.8),中国, ZL 201210110829.8。

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