• 魏景宽(JingkuanWei)

    博士、研究人员

    讲师

    一、受教育及工作经历

    2003年9月-2008年7月,河北农业大学生命学院,生物技术,理学学士
    2008年9月-2015年7月,中科院昆明动物研究所,神经生物学,神经生物学博士
    2015年9月至今,昆明理工大学灵长类转化医学研究院,讲师

     

    2003.9-2008.7: Hebei Agricultural University; Bachelor in Biology

    2008.9-2015.7: Kunming Institute of Zoology, Chinese Academy of Sciences; PhD in Neuroscience

    2015.9- present: Yunnan Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology; research scientist

    二、主要研究方向

    1. 重大神经系统疾病中的大脑皮层功能异常及其挽救手段
    2. 基于非人灵长类动物模型的干细胞治疗和基因治疗安全性和有效性评价

    My research interest is to understand and develop treatments for neurodegenerative diseases, in particular Parkinson's disease (PD) and Amyotrophic lateral sclerosis (ALS). I work in to investigating mechanisms linked to genetic and molecular pathways, explore therapeutic approaches, and identify biomarkers that may be used to monitor disease, and seek safe neuroprotective strategies to prevent, slow or stop the death of brain cells.

    三、科研领域描述

    大脑皮层是人类和其他高级哺乳动物的感觉和运动控制中心。一些重大神经系统疾病如自闭症、精神分裂症、阿茨海默症、帕金森氏症等都涉及大脑皮层的结构改变和功能紊乱。受限于研究手段和医学伦理,人们很难以人类为对象对这些疾病同时开展系统性病程进展研究和分子机理研究。我们通过环境因素或基因工程手段建立高度模拟人类疾病特征的非人灵长类动物模型,综合运用多种技术手段,纵向追踪和解析疾病的发生发展全过程,探究疾病的发病机制,并寻找恰当的干预时机对可行的治疗方案进行全面的安全性和有效性评价。

     

    In human, the cerebral cortex is the control center of sensory and motor. Structural changes and functional disorders involve in the cerebral cortex, such as PD and ALS / FTD. Technical and ethical challenges have limited our understanding of the pathological processes directly from human patient, and differences in the neocortical structure, complex neuronal circuits and behavioral paradigms preclude translating pathological findings from mouse models to the human condition. We use non-human primate models to simulate the characteristics of human diseases. By combining technologies of multiple disciplines to track and analyze the pathological process, explore the pathogenesis of diseases, and find effective solutions of disease treatment.

    四、承担科研项目情况

    1. “干细胞重大专项”:干细胞的基因组稳定性调控机制及在重大神经疾病猴模型中临床前评估(子课题2018YFA0108503),2018-2022,骨干。
    2. PD脑皮层EEG时相耦合特征提取-基于转基因猴模型的研究,2018FB118,2018-2021,主持。
    3. “干细胞及转化研究”试点专项:靶向基因编辑建立神经系统疾病猴模型及干细胞治疗研究(子课题2016YFA0101401),2017-2020,骨干。
    1. “Stem Cell and Transformation Research” Special Funds of National Key Research and Development Project: 2018YFA0108503, Preclinical evaluation of neural stem cells in monkey models of major neurological diseases. 2018-2022.
    2. Yunnan Provincial Natural Science Foundation: 2018FB118, Time-Coupled Oscillations Extraction of PD Cortex EEG: A Study Based on Transgenic Monkey Model. 2018-2021.
    3. “Stem Cell and Transformation Research” Special Funds of National Key Research and Development Project: 2016YFA0101401. Using Targeted Gene Editing to Establish a Neurological Diseases and Stem Cell Therapy Monkey Model. 2017-2020.

    五、代表性论文和专著

    1. Xiang C#, LiZN#, Huang TZ, Li JH, Yang L, Wei JK*. Threshold for maximal electroshock seizures (MEST) at three developmental stages in young mice. Zoological Research. 2019 Jan,doi: 10.24272/j.issn.2095-8137.2019.038
    2. Chen Z; Parkkonen L; Wei J; Dong JR; Ma Y; Carlson S. Prepulse Inhibition of Auditory Cortical Responses in the Caudolateral Superior Temporal Gyrus in Macaca mulatta. Neuroscience Bull. 2017 Oct 11.
    3. Chen Y.* #, J. Yu#, Y. Niu#, D. Qin#, H. Liu#, G. Li, Y. Hu, J. Wang, Y. Lu, Y. Kang, Y. Jiang, K. Wu, S. Li, J. Wei, J. He, J. Wang, X. Liu, Y. Luo, C. Si, R. Bai, K. Zhang, J. Liu, S. Huang, Z. Chen, S. Wang, X. Chen, X. Bao, Q. Zhang, F. Li, R. Geng, A. Liang, D. Shen, T. Jiang, X. Hu, Y. Ma, W. Ji* and Y. E. Sun*, Modeling Rett Syndrome Using TALEN- Edited MECP2 Mutant Cynomolgus Monkeys. Cell. 2017 May 18; 169(5): 945-955.
    4. Wei JK#, Wang WC#, Zhai RW#, Zhang YH, Yang SC, Rizak J, Li L, Xu LQ, Liu L, Pan MK, Hu YZ, Ghanemi A, Wu J, Yang LC, Li H, Lv LB, Li JL, Yao YG, Xu L, Feng XL, Yin Y, Qin DD, Hu XT*, Wang ZB*. Neurons Differentiated from Transplanted Stem Cells Respond Functionally to Acoustic Stimuli in the Awake Monkey Brain. Cell Rep., 2016, 16(4):1016-25
    5. XuJun Wu#, Ning Zhao#, Fan Bai, ChuanYu Li, CiRong Liu, JingKuan Wei, Wei Zong, LiXin Yang, Andrey E. Ryabinin, YuanYe Ma*, JianHong Wang*. Morphine-induced conditioned place preference in rhesus monkeys: Resistance to inactivation of insula and extinction. Neurobiological Learn and Memory, 2016, 131:192-200
    6. He-Qun Liu#, Jing-Kuan Wei#, Bo Li#, Fu-Qiang Xu, Yong-Yi Shen*, Xin-Tian Hu* & Ya-Ping Zhang*. Divergence of dim-light vision among bats (order: Chiroptera) as estimated by molecular and electrophysiological method. Sci Rep., 2015, 5:11531
    7. Jing He#, JingKuan Wei#, Joshua D. Rizak, YanMei Chen, JianHong Wang, XinTian Hu*, YuanYe Ma*. An odor detection system based on automatically trained mice by relative go no-go olfactory operant conditioning. Sci Rep., 2015, 5:10019
    8. Wang JH*, Wu XJ, Li CY, Wei JK, Jiang HH, Liu CR, Yu CY, Carlson S, Hu XT, Duan W, Ma YY*. Effect of morphine on conditioned place preference in rhesus monkeys. Addict Biology, 2012, 17(3):539-46
    9. Guo L, Wei J, Yang S, Wang Z*. Glaucoma model for stem cell transplantation research in New Zealand white rabbits.Dongwuxue Yanjiu. 2012 Apr;33(2):225-30. Chinese
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