白冰 (Bing Bai)

1. 2020.09-至今 昆明理工大学灵长类转化医学研究院，讲师，硕士生导师

2. 2015.09-2019.07云南省第一人民医院，博士后

3. 2011.09-2015.05 中国科学院昆明动物研究所，遗传学，理学博士

1. 2020.09-now, Institute of Primate Translational Medicine, Kunming University of Science and Technology , Lecturer

2. 2015.09-2019.07 The first hospital of Yunnan Province, PostDoc
3. 2011.09-2015.05 Kunming Institute of Zoology, CAS & Genetics, Ph.D.

1. 高通量组学大数据的整合分析

2. 胚胎早期发育阶段的遗传发育学研究
3. 发育障碍疾病的遗传学研究
4. 结合机器学习和深度学习开发单细胞组学分析方法

1. Integration analysis of high-throughput omics big data
2. Evolutional and developmental studies in early embryonic development stages
3. Genetic research on developmental disorders
4. Developing single-cell omics analysis methods using machine learning and deep learning

基于单细胞组学，结合基因组学、机器学习和深度学习等多学科知识，以探究灵长类早期发育阶段多谱系的分化和调控机制为主要目标，开展广泛合作。围绕早期发育阶段开展遗传发育学研究，解析调控胚胎早期发育的灵长类特异分子机制。同时，根据项目研究需要，进行单细胞组学分析方法的改进和开发。

Based on single-cell omics and interdisciplinary knowledge including genomics, machine learning, and deep learning, my main goal is to explore the differentiation and regulatory mechanisms of multiple lineages during the early developmental stages of primates through extensive collaboration. I focus on evolutional and developmental studies during the early developmental stages to dissect the primate-specific molecular mechanisms regulating embryonic development. Additionally, I will improve and develop single-cell omics analysis methods according to the research needs of the project.

(1) 云南省科技厅, 面上项目, 基于长读长测序探究不明原因智力低下遗传病因的研 究, 2021-06 至 2024-05, 10万元, 在研, 主持

(2) 中国博士后科学基金会,, 中国博士后科学基金面上资助, 2016-11 至 2019-07, 5万元, 结题, 主持
(3) 云南省卫健委, , 孤独症circRNA异常调控研究, 2016-01 至 2018-12, 20万 元, 结题, 主持
(4) 国家自然科学基金委员会, 地区科学基金项目,基于机器学习和异体住囊虫模型的抗衰老 化合物筛选及其机制研究, 2022-01-01 至 2025-12-31, 34万元, 在研, 参与
(5) 国家自然科学基金委员会, 地区科学基金项目, 地中海贫血和G6PD缺乏症在云南省傣族人 群共同高发机制的研究, 2019-01-01 至 2022-12-31, 34万元, 资助期满, 参与

1. Sun N#, Shao H#, Zhang Y#, Ci B#, Yao H$, Bai B*(共通讯), Tan T*. Establishing a 3D culture system for early organogenesis of monkey embryos ex vivo and single-cell transcriptome analysis of cultured embryos. STAR Protoc. 2024 Jan 13;5(1):102835.
2. Yandong Gong#, Bing Bai#(共一), Nianqin Sun#, Baiquan Ci#, Honglian Shao#, Ting Zhang#, Hui Yao, Youyue Zhang, Yuyu Niu, Lizhong Liu, Hu Zhao, Hao Wu, Lei Zhang, Tianxiang Wang, Shangang Li, Yulei Wei, Yang Yu, Ana Elisa Ribeiro Orsi, Bing Liu*, Weizhi Ji*, Jun Wu*, Yongchang Chen*, Tao Tan*. Ex utero monkey embryogenesis from blastocyst to early organogenesis. CELL.2023 May 11.186(10):2092-2110. [IF: 76.3]
3. Puyao Zhang#; Sengren Xue#; Rongrong Guo#; Jian Liu; # Bing Bai#(共一); Dexuan Li; Ahjol Hyraht; Nianqin Sun; Honglian Shao; Yong Fan; Weizhi Ji; Shihua Yang; Yang Yu; Tao Tan ; Mapping developmental paths of monkey primordial germ-like cells differentiation from pluripotent stem cells by single cell ribonucleic acid sequencing analysis, Biology of Reproduction, 2022, 107(1): 237-249 [IF:4.161]
4. Ruo Wu#; Bing Bai# (共一); Feng Li#; Raoxian Bai; Yan Zhuo; Zhengna Zhu; Rongfang Jia; Shangang Li*; Yongchang Chen*; Xiaoping Lan*; Phenotypes and genetic etiology of spontaneous polycystic kidney and liver disease in cynomolgus monkey, Frontiers in Veterinary Science, 2023, 10 (2023) [IF:3.471]
5. Bai B#, Wang Y#, Zhu R#, Zhang Y, Wang H, Fan G, Liu X, Shi H, Niu Y, Ji W*. Long-read sequencing and de novo assembly of the cynomolgus macaque genome. J Genet Genomics. 2022 Oct;49(10):975-978. doi: 10.1016/j.jgg.2021.12.013. Epub 2022 Jan 17. [IF:5.723]
6. 白冰;章锦曼;苏洁;张杰;靳婵婵;朱宝生，一例 Bainbridge-Ropers 综合征患儿遗传病因分析, 重庆医科大学学报, 2020,45(11):1593-1596
7. Bai B, Guo YR, Zhang YH, Jin CC, Zhang JM, Chen H, Zhu BS*. Novel DOCK7 mutations in a Chinese patient with early infantile epileptic encephalopathy 23. Chin Med J (Engl). 2019 Mar 5;132(5):600-603. [IF:1.585]
8. Wang, Guo Dong#; Shao, Xiu Juan#; Bai, Bing#(共一); Wang, Junlong; Wang, Xiaobo; Cao, Xue; Liu, Yan Hu; Wang, Xuan; Yin, Ting Ting; Zhang, Shao Jie; Lu, Yan; Wang, Zechong; Wang, Lu; Zhao, Wenming; Zhang*; Ruan, Jue*; Zhang, Ya Ping *; Structural variation during dog domestication: insights from gray wolf and dhole genomes, National Science Review, 2019, 6(1): 110-122 [IF=16.693]
9. Bing Bai; Wen-Ming Zhao; Bi-Xia Tang; Yan-Qing Wang; Lu Wang; Zhang Zhang; He-Chuan Yang; Yan-Hu Liu; Jun-Wei Zhu; David M. Irwin; Guo-Dong Wang; Ya-Ping Zhang ; DoGSD: the dog and wolf genome SNP database., Nucleic Acids Research, 2015, 43(Database issue): D777-D783 [IF=9.202]