博士,副教授,硕士生导师
生物信息大数据平台负责人
Ph.D., Associate professor,master's advisor
Principal Investigator in Bioinformatics big data platform
Email: daisx@lpbr.cn
一、教育及工作经历 Education and Academic Positions
二、主要研究方向 Research interests
I mainly focus on the application of bioinformatics and machine learning in target identification and drug discovery by integrating multi-omics data.
三、科研领域描述 Research Field
专注于利用生物信息学和机器学习等工具,整合疾病的多组学数据,来进行疾病的靶点识别和药物发现。以传统中草药和天然产物为出发点,发展了一系列针对多种疾病(传染疾病、癌症、神经退行性疾病等)和衰老的活性化合物预测方法和平台。为了提高药物研发效率,基于机器学习和深度学习以及化学信息学理论,开发了药物智能研发系统(DrugPredict)。
四、承担科研项目情况 Research funding
五、代表性论文 Publications
Tong L.; Dai S. X.; Kong D. J.; Yang P. P.; Tong X.; Tong X. R.; Bi X. X.; Su Y.; Zhao Y. Q.; Liu Z. C.; The genome of medicinal leech (Whitmania pigra) and comparative genomic study for exploration of bioactive ingredients, BMC Genomics, 2022, 23(1): 76.
Li W. X.; Tong X.; Yang P. P.; Zheng Y.; Liang J. H.; Li G. H.; Liu D. H.; Guan D. G.; Dai S. X.; Screening of antibacterial compounds with novel structure from the FDA approved drugs using machine learning methods, Aging, 2022, 14(3): 1448-1472.
Tan Tao#; Wu Jun#; Si Chenyang#; Dai Shaoxing#; Zhang Youyue; Sun Nianqin; Zhang E; Shao Honglian; Si Wei; Yang Pengpeng; Hong Wang; Zhenzhen Chen; Ran Zhu; Yu Kang; Reyna Hernandez-Benitez; Llanos Martinez Martinez; Estrella Nuñez Delicado; W Travis Berggren; May Schwarz; Zongyong Ai; Tianqing Li; Concepcion Rodriguez Esteban; Weizhi Ji*; Yuyu Niu*; Juan Carlos Izpisua Belmonte*; Chimeric contribution of human extended pluripotent stem cells to monkey embryos ex vivo, Cell, 2021, 184(8): 2020-2032. e2014.
Liu Dahai#; Dai Shao-Xing#; He Kan; Li Gong-Hua; Liu Justin; Liu Leyna G; Huang Jing-Fei; Xu Lin; Li Wen-Xing; Identification of hub ubiquitin ligase genes affecting Alzheimer’s disease by analyzing transcriptome data from multiple brain regions, Science Progress, 2021, 104(1): 00368504211001146.
Li Wen-Xing#; Dai Shao-Xing#; An San-Qi#; Sun Tingting#; Liu Justin; Wang Jun; Liu Leyna G; Xun Yang; Yang Hua; Fan Li-Xia; Transcriptome integration analysis and specific diagnosis model construction for Hodgkin's lymphoma, diffuse large B-cell lymphoma, and mantle cell lymphoma, Aging, 2021, 13
Wang Fang; Zhang Weiqi; Yang Qiaoyan; Kang Yu; Fan Yanling; Wei Jingkuan; Liu Zunpeng; Dai Shaoxing; Li Hao; Li Zifan; Generation of a Hutchinson–Gilford progeria syndrome monkey model by base editing, Protein & cell, 2020, 11(11): 809-824.
Li Wen-Xing; Li Gong-Hua; Tong Xin; Yang Peng-Peng; Huang Jing-Fei*; Xu Lin*; Dai Shao-Xing*; Systematic metabolic analysis of potential target, therapeutic drug, diagnostic method and animal model applicability in three neurodegenerative diseases, Aging, 2020, 12(10): 9882.
Li Gong-Hua; Dai Shaoxing; Han Feifei; Li Wenxin; Huang Jingfei; Xiao Wenzhong; FastMM: an efficient toolbox for personalized constraint-based metabolic modeling, BMC Bioinformatics, 2020, 21(1): 1-7.
Li Bing-xiang; Zhang Han; Liu Yubin; Li Ya; Zheng Jun-juan; Li Wen-Xing; Feng Kai; Sun Ming*; Dai Shao-Xing*; Novel pathways of HIV latency reactivation revealed by integrated analysis of transcriptome and target profile of bryostatin, Scientific Reports, 2020, 10(1): 1-12.
Liu Jia-Qian; Li Wen-Xing; Zheng Jun-Juan; Tian Qing-Nan; Huang Jing-Fei*; Dai Shao-Xing*; Gain and loss events in the evolution of the apolipoprotein family in vertebrata, BMC evolutionary biology, 2019, 19(1): 1-10.
Li Huijuan; Zhou Dong-Sheng; Chang Hong; Wang Lu; Liu Weipeng; Dai Shao-Xing; Zhang Chen; Cai Jun; Liu Weiqing; Li Xingxing; Interactome Analyses implicated CAMK2A in the genetic predisposition and pharmacological mechanism of Bipolar Disorder, Journal of psychiatric research, 2019, 115(165-175).
Zhou Xia; Li Gonghua; An Sanqi; Li Wen-Xing; Yang Huihui; Guo Yicheng; Dai Zhi; Dai Shaoxing; Zheng Junjuan; Huang Jingfei; A new method of identifying glioblastoma subtypes and creation of corresponding animal models, Oncogene, 2018, 37(35): 4781-4791.
Zheng Jun-Juan; Li Wen-Xing; Liu Jia-Qian; Guo Yi-Cheng; Wang Qian; Li Gong-Hua*Dai Shao-Xing*; Huang Jing-Fei*; Low expression of aging-related NRXN3 is associated with Alzheimer disease: A systematic review and meta-analysis, Medicine, 2018, 97(28):
Li Hui‑Juan; Li Wen‑Xing; Dai Shao‑Xing; Guo Yi‑Cheng; Zheng Jun‑Juan; Liu Jia‑Qian; Wang Qian; Chen Bi‑Wen; Li Gong‑Hua; Huang Jing‑Fei; Identification of metabolism-associated genes and pathways involved in different stages of clear cell renal cell carcinoma, Oncology Letters, 2018, 15(2): 2316-2322.
Chen Bi-Wen; Li Wen-Xing; Wang Guang-Hui; Li Gong-Hua; Liu Jia-Qian; Zheng Jun-Juan; Wang Qian; Li Hui-Juan; Dai Shao-Xing*; Huang Jing-Fei*; A strategy to find novel candidate anti-Alzheimer’s disease drugs by constructing interaction networks between drug targets and natural compounds in medical plants, PeerJ, 2018, 6(e4756.
Wang Qian; Li Wen-Xing; Dai Shao-Xing; Guo Yi-Cheng; Han Fei-Fei; Zheng Jun-Juan; Li Gong-Hua; Huang Jing-Fei; Meta-Analysis of Parkinson’s Disease and Alzheimer’s Disease Revealed Commonly Impaired Pathways and Dysregulation of NRF2-Dependent Genes, Journal of Alzheimer's Disease, 2017, 56(4): 1525-1539.
Liu Jia-Qian#; Dai Shao-Xing#; Zheng Jun-Juan; Guo Yi-Cheng; Li Wen-Xing; Li Gong-Hua; Huang Jing-Fei; The identification and molecular mechanism of anti-stroke traditional Chinese medicinal compounds, Scientific Reports, 2017, 7(41406).
Li Wen-Xing; Qi Fei; Liu Jia-Qian; Li Gong-Hua; Dai Shao-Xing; Zhang Tao; Cheng Fei; Liu Dahai; Zheng Song Guo; Different impairment of immune and inflammation functions in short and long-term after ischemic stroke, American Journal of Translational Research, 2017, 9(2): 736.
Li Wen-Xing; He Kan; Tang Ling; Dai Shao-Xing; Li Gong-Hua; Lv Wen-Wen; Guo Yi-Cheng; An San-Qi; Wu Guo-Ying; Liu Dahai; Comprehensive tissue-specific gene set enrichment analysis and transcription factor analysis of breast cancer by integrating 14 gene expression datasets, Oncotarget, 2017, 8(4): 6775.
Li Wen-Xing; Cheng Fei; Zhang A-Jie; Dai Shao-Xing; Li Gong-Hua; Lv Wen-Wen; Zhou Tao; Zhang Qiang; Zhang Hong; Zhang Tao; Folate deficiency and gene polymorphisms of MTHFR, MTR and MTRR elevate the hyperhomocysteinemia risk, Clin Lab, 2017, 63(3): 523-533.
Li Wen-Xing#; Dai Shao-Xing#; Wang Qian; Guo Yi-Cheng; Hong Yi; Zheng Jun-Juan; Liu Jia-Qian; Liu Dahai; Li Gong-Hua; Huang Jing-Fei; Integrated analysis of ischemic stroke datasets revealed sex and age difference in anti-stroke targets, PeerJ, 2016, 4(e2470).
Li Wen-Xing#; Dai Shao-Xing#; Liu Jia-Qian; Wang Qian; Li Gong-Hua; Huang Jing-Fei; Integrated Analysis of Alzheimer’s Disease and Schizophrenia Dataset Revealed Different Expression Pattern in Learning and Memory, Journal of Alzheimer's Disease, 2016, 51(2): 417-425.
Han Feifei; Li Gonghua; Dai Shaoxing; Huang Jingfei; Genome-wide metabolic model to improve understanding of CD4+ T cell metabolism, immunometabolism and application in drug design, Molecular BioSystems, 2016, 12(2): 431-443.
Guo Yi-Cheng; Zhang Lin; Dai Shao-Xing; Li Wen-Xing; Zheng Jun-Juan; Li Gong-Hua; Huang Jing-Fei; Independent evolution of winner traits without whole genome duplication in Dekkera yeasts, PLOS ONE, 2016, 11(5): e0155140.
Dai Shao-Xing; Li Wen-Xing; Li Gong-Hua; Huang Jing-Fei; Proteome-wide prediction of targets for aspirin: new insight into the molecular mechanism of aspirin, PeerJ, 2016, 4(e1791).
Dai Shao-Xing; Li Wen-Xing; Han Fei-Fei; Guo Yi-Cheng; Zheng Jun-Juan; Liu Jia-Qian; Wang Qian; Gao Yue-Dong; Li Gong-Hua; Huang Jing-Fei; In silico identification of anti-cancer compounds and plants from traditional Chinese medicine database, Scientific Reports, 2016, 6(1): 1-11.
Dai Shao-Xing; Li Gong-Hua; Gao Yue-Dong; Huang Jing-Fei; Pharmacophore-Map-Pick: A Method to Generate Pharmacophore Models for All Human GPCRs, Molecular Informatics, 2016, 35(2): 81-91.
Li Wen-Xing; Lv Wen-Wen; Dai Shao-Xing; Pan Ming-Luo; Huang Jing-Fei; Joint associations of folate, homocysteine and MTHFR, MTR and MTRR gene polymorphisms with dyslipidemia in a Chinese hypertensive population: a cross-sectional study, Lipids in health and disease, 2015, 14(1): 1.
Li Wen-Xing#; Dai Shao-Xing#; Zheng Jun-Juan; Liu Jia-Qian; Huang Jing-Fei; Homocysteine Metabolism Gene Polymorphisms (MTHFR C677T, MTHFR A1298C, MTR A2756G and MTRR A66G) Jointly Elevate the Risk of Folate Deficiency, Nutrients, 2015, 7(8): 6670-6687.
Jiang Hong-Yan; Li Guo-Dong; Dai Shao-Xing; Bi Rui; Zhang Deng-Feng; Li Zong-Fang; Xu Xiu-Feng; Zhou Tai-Cheng; Yu Li; Yao Yong-Gang; Identification of PSEN1 mutations p. M233L and p. R352C in Han Chinese families with early-onset familial Alzheimer's disease, Neurobiology of aging, 2015, 36(3): 1602. e1603-1602. e1606.
Wang Rui-Rui; Yang Qing-Hua; Luo Rong-Hua; Peng You-Mei; Dai Shao-Xing; Zhang Xing-Jie; Chen Huan; Cui Xue-Qing; Liu Ya-Juan; Huang Jing-Fei; Azvudine, a novel nucleoside reverse transcriptase inhibitor showed good drug combination features and better inhibition on drug-resistant strains than lamivudine in vitro, PLOS ONE, 2014, 9(8): e105617.
Zhang Ai-Di; Dai Shao-Xing; Huang Jing-Fei; Reconstruction and analysis of human kidney-specific metabolic network based on omics data, BioMed research international, 2013
Li Zhonghua; Li Tiehai; Dai Shaoxing; Xie Xiaoli; Ma Xiaofeng; Zhao Wei; Zhang Weimin; Li Jing; Wang Peng George; New Insights into the Pharmacological Chaperone Activity of C2-Substituted Glucoimidazoles for the Treatment of Gaucher Disease, ChemBioChem, 2013, 14(10): 1239-1247.
Dai Shao-Xing; Zhang Ai-Di; Huang Jing-Fei; Evolution, expansion and expression of the Kunitz/BPTI gene family associated with long-term blood feeding in Ixodes Scapularis, BMC evolutionary biology, 2012, 12(1): 1-16.
论文网站(动态更新) https://scholar.google.com/citations?user=d4cYz1YAAAAJ
六、申请专利 Patents
七、实验室成员
硕士研究生:
2019级:仝新
2020级:郑阳,梁积浩
2021级:朱然,朱正娜,贾荣芳
2022级:陈志远,李淑涵,吕豪豪,张仁鑫
博士研究生:
2021级:杨鹏鹏
工作人员:
白冰
白冰
博士,讲师
主要研究方向:
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