张慧（Hui Zhang）

1. 2014.9-2017.7，理学博士，西藏大学医学院生态学专业高原生态环境变迁与人群健康方向，导师：崔超英

2. 2003.9-2006.07，医学硕士，昆明医科大学云南省天然药物药理重点实验室药理学专业，导师：李玛琳

3. 1997.9-2001.7，理学学士，山东大学生命科学院生物技术专业

1. Ph.D. in Ecology, School of Medicine ,Tibet University, 2014.9-2017.7

2. M.S. in Pharmacology, Yunnan Provincial Key Laboratory of Pharmacology for Natural Products，Kunming Medical University, 2003.9-2006.07

3. B.S. in Biotechnology, School of Life Sciences，Shandong University, 1997.9-2001.7

1. 2022.1-至今：副教授，硕士生导师，昆明理工大学灵长类转化医学研究院

2. 2021.1-2022.1，副研究员，中国科学院昆明动物研究所

3. 2010.9-2020.12，助理研究员，中国科学院昆明动物研究所

4. 2006.7-2010.9，研究实习员，中国科学院昆明动物研究所

1.  Jan. 2022-Present, Associate Professor, StateKey Laboratory of Non-Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology.

2.  Jan. 2021-Jan. 2022, Associate Professor, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences.

3.  Sept. 2010-Dec. 2020, Assistant Professor, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences.

4.  Jul. 2006- Sept. 2010, Research Assistant, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences.

1. 遗传分析与测序平台技术支撑

Genetic Analysis and Sequencing Platform Technical Support

2. 灵长类多组学与疾病的遗传机制

Genetic Mechanism underlying Primate multi-omics and Disease

3. 低氧损伤与适应机制

Mechanism underlying Hypoxic Acclimatization and Adaptation

1、遗传分析与测序平台

建立包括单细胞测序在内的各种多组学测序文库构建技术、多组学数据质控与分析流程、多组学功能元件发掘等组学分析方法，为灵长类转化医学研究院提供高质量的组学建库与测序技术支撑。

Establishing Genetic Analyses and Sequencing Platform support for School of Primate Translational Medicine, including multi-omics library construction, quality control and analytical pipeline for sequencing data, data mining for functional genomic elements in primates etc.

2、灵长类多组学与疾病的遗传机制

利用灵长类动物模型进行高原特殊疾病的生理和多组学分子机制研究

Deciphering genetic mechanism of plateau specific diseases underlying the multi-omics and disease in primate model.

3、低氧损伤与适应机制

高原环境导致的地方性疾病（高原先心病、高原衰退症等）的致病机制研究

Deciphering genomic pathogenic mechanism of endemic diseases caused by hypoxia.

1. 云南省中青年学术带头人后备人才，2023-2026，12万，主持；

2. 国家自然科学基金面上项目，32170629，汉藏人群脐静脉内皮细胞的多组学比较与高原适应分子机制的解析，2022/01- 2025/12，直接经费58万，在研，主持。

Multi-omics comparison of umbilical vein endothelial cells between Han and Tibetan populations and dissection of molecular mechanism of

high altitude adaptation, National Science Foundation of China (NSFC), General Project, 32170629, 2022.01-2025.12, 580,000 RMB Yuan. Ongoing, Principal Investigator.

3. 云南省自然科学基金面上项目，2019FB042，利用CRISPR/Cas9定点突变小鼠和多组学分析解析藏族高原低氧适应关键基因EGLN1的功能，2019/10-2022/09，10万，结题，主持。

Using CRISPR/Cas9 mice and multiomics to analyze the function of Tibetan plateau hypoxia adaptation gene EGLN1, Yunnan Natural Science Foundation, General Project, 2019FB042, 2019.10-2022.09, 100,000 RMB Yuan. Completed, Principal Investigator.

4. 国家自然科学基金青年科学基金项目，31501013，藏族人群对高原低氧适应的关键基因EGLN1的功能解析，2016/01-2018/12，22.8万元，结题，主持。

Function analysis of the key gene EGLN1 of the Tibetan population for the hypoxia adaptation on the plateau , National Science Foundation of China (NSFC), Youth Project, 31501013, 2016.01 – 2018.12, 228000 RMB Yuan. Completed, Principal Investigator.

1. 张慧（4/6）,灵长类大脑进化与人类智力起源的遗传机制,云南省人民政府，云南省自然科学奖，一等奖，2014（宿兵，石宏，祁学斌，张慧，张锐，卢志祥）

The first prize award of natural science research of Yunnan province of China, 2014

1) Zhang, X. #, Liu, Q. #, Zhang, H. #, Zhao, S. #, Huang, J., Sovannary, T., Bunnath, L., Aun, H.S., Samnom, H., Su, B.* & Chen, H.* The distinct morphological phenotypes of Southeast Asian aborigines are shaped by novel mechanisms for adaptation to tropical rainforests. National Science Review (2021)

2) Xin, J. #, Zhang, H. #, He, Y. #, Duren, Z. #, Bai, C. #, Chen, L., Luo, X., Yan, D.-S., Zhang, C., Zhu, X., Yuan, Q., Feng, Z., Cui, C., Qi, X., Ouzhuluobu, Wong, W.H. *, Wang, Y.*& Su, B.* Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation. Nature Communications 11, 4928 (2020).

3) Zhang, H.#, He, Y.#, Cui, C.#, Ouzhuluobu, Baimakangzhuo, Duojizhuoma, Dejiquzong, Bianba, Gonggalanzi, Pan, Y., Qula, Kangmin, Cirenyangji, Baimayangji, Bai, C., Guo, W., Yangla, Peng, Y., Zhang, X., Xiang, K., Yang, Z., Liu, S., Tao, X., Gengdeng, Zheng, W., Guo, Y., Wu, T., Qi, X.* & Su, B*. Cross-altitude analysis suggests a turning point at the elevation of 4,500m for polycythemia prevalence in Tibetans. American Journal of Hematology (2017).

4) Peng, Y.#, Cui, C.#, He, Y.#, Ouzhuluobu#, Zhang, H.#, Yang, D., Zhang, Q., Bianbazhuoma, Yang, L., He, Y., Xiang, K., Zhang, X., Bhandari, S., Shi, P., Yangla, Dejiquzong, Baimakangzhuo, Duojizhuoma, Pan, Y., Cirenyangji, Baimayangji, Gonggalanzi, Bai, C., Bianba, Basang, Ciwangsangbu, Xu, S., Chen, H., Liu, S., Wu, T., Qi, X.* & Su, B*. Down-Regulation of EPAS1 Transcription and Genetic Adaptation of Tibetans to High-Altitude Hypoxia. Molecular Biology and Evolution 34, 818-830 (2017).

5) Li, M.#, Zhang, H.#, Luo, X.J., Gao, L., Qi, X.B., Gourraud, P.A. & Su, B*. Meta-analysis indicates that the European GWAS-identified risk SNP rs1344706 within ZNF804A is not associated with schizophrenia in Han Chinese population. PLoS One 8, e65780 (2013).

6) Peng, Y., Yang, Z., Zhang, H.#, Cui, C., Qi, X., Luo, X., Tao, X., Wu, T., Ouzhuluobu, Basang, Ciwangsangbu, Danzengduojie, Chen, H., Shi, H.* & Su, B*. Genetic variations in Tibetan populations and high-altitude adaptation at the Himalayas. Molecular Biology and Evolution 28, 1075-81 (2011).

7) Niu, A., Wang, Y., Zhang, H.#, Liao, C., Wang, J., Zhang, R., Che, J. & Su, B. Rapid evolution and copy number variation of primate RHOXF2, an X-linked homeobox gene involved in male reproduction and possibly brain function. BMC Evolutionary Biology 11, 298 (2011).

8) He, Y.#, Li, J.#, Yue, T.#, Zheng, W.#, Guo, Y.#, Zhang, H., Chen, L., Li, C., Li, H., Cui, C., Ouzhuluobu*, Qi, X.* & Su, B.* Seasonality and Sex-Biased Fluctuation of Birth Weight in Tibetan Populations. Phenomics DOI: 10.1007/s43657-021-00038-7 (2022).

9) He, Y.#, Qi, X.#, Ouzhuluobu#, Liu, S.#, Li, Jun #, Zhang, H, Baimakangzhuo, Bai, C, Zheng, W., Guo, Y., Duojizhuoma, Baimayangji, Dejiquzong, Bianba, Gonggalanzi, Pan, Y, Qula, Kangmin, Cirenyangji, Guo, W., Yangla, Peng, Y, Zhang X., Xiang, K., Yang, Z., Wang, L., Gengdeng, Zhang, Y. Wu, T., Su, B.*&Cui Chaoying *. Blunted Nitric Oxide Regulation in Tibetans under High Altitude Hypoxia. National Science Review (2018)

10) Bhandari, S.#, Zhang, X.#, Cui, C.#, Yangla, Liu, L., Ouzhuluobu, Baimakangzhuo, Gonggalanzi, Bai, C., Bianba, Peng, Y., Zhang, H., Xiang, K., Shi, H., Liu, S., Gengdeng, Wu, T., Qi, X.* & Su, B*. Sherpas share genetic variations with Tibetans for high-altitude adaptation. Mol Genet Genomic Med 5, 76-84 (2017).

11) Guo, Y.#, He, Y.#, Cui, C.#, Ouzhuluobu, Baimakangzhuo, Duojizhuoma, Dejiquzong, Bianba, Peng, Y., Bai, C., Gonggalanzi, Pan, Y., Qula, Kangmin, Cirenyangji, Guo, W., Yangla, Zhang, H., Zhang, X., Zheng, W., Xu, S., Chen, H., Zhao, S., Cai, Y., Liu, S., Wu, T., Qi, X.* & Su, B.* GCH1 plays a role in high altitude adaptation of Tibetans. Zoological Research, 38, 155-162 (2017).

12) Zheng, W.#, He, Y.#, Cui, C.#, Ouzhuluobu, Dejiquzong, Peng, Y., Bai, C., Duojizhuoma., Gonggalanzi, Bianba, Baimakangzhuo, Pan, Y., Qula, Kangmin, Cirenyangji, Guo, W., Yangla, Zhang, H., Zhang, X., Guo, Y., Xu, S., Chen, H., Zhao, S., Cai, Y., Liu, S., Wu, T., Qi, X.* & Su, B.* EP300 contributes to high altitude adaptation of Tibetans by regulating nitric oxide production. Zoological Research, 38, 163-170 (2017).

13) Yang, D.#, Peng, Y.#, Ouzhuluobu#, Bianbazhuoma#, Cui, C.#, Bianba, Wang, L., Xiang, K., He, Y., Zhang, H., Zhang, X., Liu, J., Shi, H., Pan, Y., Duojizhuoma, Dejiquzong, Cirenyangji, Baimakangzhuo, Gonggalanzi, Liu, S., Gengdeng, Wu, T., Chen, H., Qi, X.* & Su, B.* HMOX2 Functions as a Modifier Gene for High-Altitude Adaptation in Tibetans. Hum Mutat 37, 216-23 (2016).

14) Yang, Z.#, Zhong, H.#, Chen, J.#, Zhang, X.#, Zhang, H., Luo, X., Xu, S., Chen, H., Lu, D., Han, Y., Li, J., Fu, L., Qi, X., Peng, Y., Xiang, K., Lin, Q., Guo, Y., Li, M., Cao, X., Zhang, Y., Liao, S., Peng, Y., Zhang, L., Guo, X., Dong, S., Liang, F., Wang, J., Willden, A., Seang Aun, H., Serey, B., Sovannary, T., Bunnath, L., Samnom, H., Mardon, G., Li, Q., Meng, A., Shi, H. & Su, B. A Genetic Mechanism for Convergent Skin Lightening during Recent Human Evolution. Mol Biol Evol 33, 1177-87 (2016).

15) Bhandari, S.#, Zhang, X.#, Cui, C.#, Bianba, Liao, S., Peng, Y., Zhang, H., Xiang, K., Shi, H., Ouzhuluobu, Baimakongzhuo, Gonggalanzi, Liu, S., Gengdeng, Wu, T., Qi, X.* & Su, B.* Genetic evidence of a recent Tibetan ancestry to Sherpas in the Himalayan region. Sci Rep 5, 16249 (2015).

16) Xiang, K., Ouzhuluobu, Peng, Y., Yang, Z., Zhang, X., Cui, C., Zhang, H., Li, M., Zhang, Y., Bianba, Gonggalanzi, Basang, Ciwangsangbu, Wu, T., Chen, H., Shi, H., Qi, X. & Su, B. Identification of a Tibetan-specific mutation in the hypoxic gene EGLN1 and its contribution to high-altitude adaptation. Mol Biol Evol 30, 1889-98 (2013).

17) Qi, X.#, Cui, C.#, Peng, Y.#, Zhang, X.#, Yang, Z.#, Zhong, H., Zhang, H., Xiang, K., Cao, X., Wang, Y., Ouzhuluobu, Basang, Ciwangsangbu, Bianba, Gonggalanzi, Wu, T., Chen, H., Shi, H.* & Su, B*. Genetic evidence of paleolithic colonization and neolithic expansion of modern humans on the tibetan plateau. Mol Biol Evol 30, 1761-78 (2013).

18) Zhang, X.#, Qi, X.#, Yang, Z.#, Serey, B., Sovannary, T., Bunnath, L., Seang Aun, H., Samnom, H., Zhang, H., Lin, Q., van Oven, M., Shi, H.* & Su, B*. Analysis of mitochondrial genome diversity identifies new and ancient maternal lineages in Cambodian aborigines. Nat Commun 4, 2599 (2013).