魏景宽 (Jingkuan Wei)

1. 2015年9月至今，昆明理工大学/灵长类转化医学研究院，讲师

2. 2008年9月－2015年7月，中科院昆明动物研究所，神经生物学，理学博士

3. 2003年9月－2008年7月，河北农业大学/生命学院，生物技术，理学学士

1. 2015.9-now, Lecturer,Institute of Primate Translational Medicine, Kunming University of Science and Technology.

2. 2008.9-2015.7,Kunming Institute of Zoology, CAS & Neuroscience, Ph.D.

3. 2003.9-2007.7,Agricultural University of Hebei, Bachelor of Science.

重大神经系统疾病,如帕金森病（PD）、肌萎缩侧索硬化症（ALS）、癫痫等都涉及大脑皮层结构改变和功能紊乱。灵长类动物与人亲缘关系近，基因、生理和行为相似，是开展系统性病理进展、分子机理研究和干预治疗的理想模型。我们在解析并深入理解疾病机制基础上，发展和建立高度模拟人类疾病特征的病因性灵长类动物模型，综合运用多种技术手段，纵向追踪和解析疾病的发生发展全过程，探究开发恰当的治疗策略方法和干预手段，对治疗方案进行全面的安全性和有效性评价，推动临床转化。

Major neurodegenerative diseases, includingParkinson's Disease (PD), Amyotrophic Lateral Sclerosis (ALS), and epilepsy, involve alterations in cortical structures and brain dysregulation. Primates are ideal models for studies of disease progression, molecular mechanisms, and therapy development due to their similarities to humans. Building upon our understanding of disease mechanisms, we aim to develop etiological primate models mimicking human disease characteristics, track and analyze disease progression for therapeutic strategy development, and assess treatment safety and efficacy for clinical translation.

1. 解析复杂发育和退行性神经疾病（PD、ALS、癫痫)的致病机理

2. 利用灵长类动物模型探索细胞治疗及神经调控干预复杂神经疾病的新策略和新方法

1. Deciphering the pathogenic mechanisms ofcomplex neurological diseases, including PD, ALS and Epilepsy.

2. Exploring new strategies and methods for celltherapy and neuromodulation interventions in complex neurological diseases using primate models.

1. 云南省基础研究重点项目，光固化止血水凝胶搭载生物活性小因子治疗创伤性脑损伤的研究（202301AS070115），2024/03-2027/02，项目负责人, 50万元。

2. 国家自然科学基金，C9orf72内含子重复扩增突变产生的Ploy-PR蛋白在灵长类动物神经退行性变中的作用机制（32260197），2023/1-2026/12，项目负责人, 34万元。

3. 云南省人社厅人才培养经费，万人计划青年拔尖人才（YNWR-QNBJ-2020-133），2021/09-2025/12，项目负责人, 50万元。

4. 国家自然科学基金，肌萎缩侧索硬化症灵长类动物转基因模型的建立及早期发病机制研究（32070541），2021/1-2024/12，参与, 58万元。

5. 国家重点研发计划课题，神经干细胞在重大神经疾病猴模型中临床前评估（2018YFA0108503），2018/07-2022/12、子课题负责人，210万元。

6. 国家重点研发计划课题，靶向基因编辑技术优化及灵长类神经系统疾病动物模型的建立（2016YFA0101401），2016/07-2020/12，课题骨干

7. 国家自然科学基金面上项目， 早期逆境负面效应的逆转—基于非人灵长类的研究，2013/01-2016/12，参与，78万元。

1. Jianing Shen#, Ning Bian#, Lu Zhao*, Jingkuan Wei*.The role of T-lymphocytes in central nervous system diseases. Brain Research Bulletin. 2024 Feb 20; 209: 110904.
2. Lizhu Xu#, Dan Wang#, Lu Zhao#, Zhengsheng Yang, Xu Liu,Xinyue Li, Tingli Yuan, Ye Wang, Tianzhuang Huang, Ning Bian, Yuqun He, Xinglong Chen, Baohong Tian, Zexian Liu, Fucheng Luo, Wei Si, Guangping Gao*, Weizhi Ji*, Yuyu Niu*, Jingkuan Wei*. C9orf72 poly-(PR) aggregation innucleus induces ALS/FTD-related neurodegeneration in cynomolgus monkeys. Neurobiology of Disease. 2023 Aug; 184:106197.
3. Jingkuan Wei#, Shaoxing Dai#, YapingYan#, Shulin Li, Pengpeng Yang, Ran Zhu, Tianzhuang Huang, Xi Li, Yanchao Duan, Zhengbo Wang*, Weizhi Ji*, Wei Si*. Spatiotemporal proteomic atlas of multiple brain regions across early fetal to neonatal stages in cynomolgus monkey. Nature Communications. 2023 Jul 3; 14(1): 3917.
4. Xue Gan#, Jiahan Ren#, Tianzhuang Huang#, Kunhua Wu,Shulin Li, Yanchao Duan, Zhengbo Wang, Wei Si*, Jingkuan Wei*. Pathologicalα-synuclein accumulation, CSF metabolites changes and brain microstructures in cynomolgus monkeys treated with 6-hydroxydopamine. Neurotoxicology. 2023 Jan; 94: 172-181.
5. Jun Li#, Nan Li#, Jingkuan Wei#, Chun Feng,Yanying Chen, Tingwei Chen, Zongyong Ai, Xiaoqing Zhu, Weizhi Ji* and Tianqing Li*. Genetically engineered mesenchymal stem cells with dopamine synthesis for Parkinson’s disease in animal models. npj Parkinson’s Disease 2022 Dec 22;8(1):175.
6. Renli Qi, Minshu Wang, Qian Zhong, Lanlin Wang, XinwangYang, Baihui Huang, Zhengsheng Yang, Cong Zhang, Xin Geng, Cheng Luo, Wei Wang, Jinghui Li*, Hualin Yu*, Jingkuan Wei*. Chronic vagus nerve stimulation(VNS) altered IL-6, IL-1β, CXCL-1 and IL-13 levels in the hippocampus of rats with LiCl-pilocarpine-induced epilepsy. Brain Research. 2022 Apr 1;1780 (147800).
7. Zhong, Tao#; Wei, Jingkuan#; Wu, Kunhua; Chen,Liangjun; Zhao, Fenqiang; Pei, Yuchen; Wang, Ya; Zhang, Hongjiang; Wu, Zhengwang; Huang, Ying; Li, Tengfei; Wang, Li; Chen, Yongchang; Ji, Wei zhi; Zhang, Yu; Li, Gang*; Niu, Yuyu*. Longitudinal brain atlases of early developing cynomolgus macaques from birth to 48 months of age, NeuroImage, 2022, 247(118799).
8. Yanmei Chen, Yiling Ni, Jianhong Zhou, Hua Zhou, QianZhong, Xinyue Li, Jichuan Zhang, Yuanye Ma, Jingkuan Wei*. The Amygdala Responds Rapidly to Flashes Linked toDirect Retinal Innervation: A Flash-evoked Potential Study Across Cortical and Subcortical Visual Pathways. Neuroscience. Bulletin. 2021 Aug;37(8):1107-1118.
9. Cheng Xiang#, Zhi-Na Li#, Tian-Zhuang Huang, Jing-hui Li,Lei Yang, Jing-Kuan Wei*. Thresholdfor maximal electroshock seizures (MEST) at three developmental stages in young mice. Zoological Research. 2019 May18;40(3)
10. Wei, Jing-Kuan#; Wang, Wen-Chao#; Zhai, Rong-Wei#; Zhang, YH; Yang, SC;R, Joshua; Li, L; Xu, LQ; Liu, L; Pan, MK; Hu, YZ; G, Abdelaziz; Wu, J; Yang, LC; Li, H; Lv, LB; Li, JL; Yao, YG; Xu, L; Feng, XL; Yin, Y; Qin, DD; Hu, Xin-Tian*; Wang, Zheng-Bo*; Neurons Differentiated from Transplanted Stem Cells Respond Functionally to Acoustic Stimuli in the Awake Monkey Brain. Cell Reports, 2016, 16(4): 1016-1025.
11. He-Qun Liu#, Jing-Kuan Wei#, Bo Li#, Ming-Shan Wang,Rui-Qi Wu, Joshua D. Rizak, Li Zhong, Lu Wang, Fu-Qiang Xu, Yong-Yi Shen*, Xin-Tian Hu* & Ya-Ping Zhang*. Divergence of dim-light vision among bats (order: Chiroptera) as estimated by molecular and electrophysiological method. Scientific Reports, 2015, 5:11531
12. Jing He#, JingKuan Wei#,Joshua D. Rizak, YanMei Chen, JianHong Wang, XinTian Hu*, YuanYe Ma*. Anodor detection system based on automatically trained mice by relative go no-go olfactory operant conditioning. Scientific Reports 2015, 5:10019

1. 魏景宽; 张磊; 申佳宁; 李勇; 李宁; 潘杨萍. 用于创伤性脑损伤的可注射光固化止血水凝胶的制备方法，2022-10-01，中国， 202210556695.6

2. 魏景宽; 何静; 王建红; 一种实验猴上肢拉力测试装置, 2018-04-27, 中国, ZL201810392799.1.

3. 何静; 魏景宽; 马原野; 小鼠气味训练探测器和气味干扰仿真装置及训练方法, 2014-12-31, 中国, ZL201310161977.7.