• 罗富成(Fucheng Luo)

    博士, 教授

    Ph.D, Professor

    E-mail: luofc@lpbr.cn

    一、教育背景及工作经历 ( Education and Work Experience )

    1. 2019年12月 至今: 昆明理工大学灵长类转化医学研究院, 教授

    2. 2018年5月至2019年12月:美国辛辛那提大学(University of Cincinnati)医学院,博士后

    3. 2012年10月至2018年4月:美国凯斯西储大学(Case Western Reserve University)医学院,博士后

    4. 2007年9月至2012年9月:昆明理工大学环境科学与工程学院,获博士学位

    5. 2003年9月至2007年8月:昆明理工大学生命科学与技术学院,获学士学位

    二、主要研究方向 (Research Interest)

    1. 神经胚形成的机制 

    2. 少突胶质细胞发育与髓鞘形成的调控机制 

    3. 脑老化及损伤修复的神经可塑性机制 

    三、科研领域描述 (Description ofScientific Research)

    大脑是人体中发育最早、成熟最晚、最为完善的器官,至今仍存在许多未解之谜。大脑如何从无到有并发育成熟?如何延缓脑老化与防止脑疾病的发生?如何促进神经再生?这些问题一直是脑科学研究中的重要问题。针对这些科学问题,我们以胚胎干细胞、基因修饰小鼠、灵长类动物(恒河猴与食蟹猴)以及人脑类器官作为研究模型,综合运用分子生物学、电生理学、行为学、单细胞多组学技术、透射电镜、核磁共振成像等技术手段,开展脑科学研究。 

    四、承担科研项目(Research Funding)

     1. 国家自然科学基金-地区科学基金项目(#82060234), 2021-01到2024-12,在研,主持 

    五、代表性论文(Selected Publications)

    1. Fucheng Luo, Zhen Zhang and Yu Luo*. Differential Role of p53 in Oligodendrocyte Survival in Response to Various Stresses: Experimental Autoimmune Encephalomyelitis, Cuprizone Intoxication or White Matter Stroke. Int. J. Mol. Sci. 2021, 22, 12811. https://doi.org/10.3390/ijms222312811
    2. Fucheng Luo, Zhen Zhang, Austin Barnett, Tania J. Bellinger, FlaviaTurcatoa, Kelly Schmidta, Yu Luo*, Cuprizone-induced demyelination under physiological and post-stroke condition leads to decreased neurogenesis response in adult mouse brain. Experimental Neurology, 2020.326:113168
    3. Fucheng Luo#, Amanda Phuong Tran#, Li Xin, Chandrika Sanapala, Bradley T. Lang, Jerry Silver*, Yan Yang*, Modulation of proteoglycan receptor PTPσ enhances MMP-2 activity to promote recovery from multiple sclerosis. Nature Communications, 2018. DOI: 10.1038/s41467-018-06505-6
    4. Fucheng Luo, Jessie Zhang, Kathryn Burk, Rita R. Romito-DiGiacomo, Robert H. Miller*, Yan Yang*, Oligodendrocyte-specific loss of Cdk5 disrupts the architecture of nodes of Ranvier as well as learning and memory. Experimental Neurology, 2018.306:92-104
    5. Fucheng Luo, Karl Herrup, Xin Qi*, Yan Yang*, Inhibition of Drp1 hyper-activation is protective in animal models of experimental multiple sclerosis. Experimental Neurology, 2017.292:21-34
    6. Fucheng Luo, Jessie Zhang, Kathryn Burke, Robert H. Miller*, Yan Yang*, The activators of Cdk5 p35 and p39 are essential for oligodendrocyte maturation, process formation and myelination. Journal of Neuroscience. 2016. 36(10):3024-3037
    7. Fucheng Luo, Kathryn Burke, Christopher Kantor, Robert H. Miller*, Yan Yang*, Cyclin-dependent kinase 5 mediates adult OPC maturation and myelin repair through modulation of Akt and GsK-3beta signaling. Journal of Neuroscience, 2014. 34(31): p. 10415-29
    8. Fucheng Luo, Yuemei Feng, Lu Zhao, Kui Li, Shengdong Wang, Junying Song, Jie Bai*, Thioredoxin-1 expression regulated by morphine in SH-SY5Y cells. Neuroscience Letters, 2012. 523(1): 50-5
    9. Fucheng Luo, Lei Qi, Tao Lv, Shengdong Wang,Hua Liu, Hajime Nakamura, Junji Yodoi, Jie Bai*, Geranylgeranylacetone protects mice against morphine-induced hyperlocomotion, rewarding effect, and withdrawal syndrome. Free Radical Biology and Medicine, 2012.52(7): 1218-27.
    10. Fucheng Luo, Jia Zhou, Tao Lv, Lei Qi, Shengdong Wang, Hajime Nakamura, Junji Yodoi, Jie Bai*, Induction of endoplasmic reticulum stress and the modulation of thioredoxin-1 in formaldehyde-induced neurotoxicity. NeuroToxicology, 2012. 33(3): 290-8.
    11. Fucheng Luo, Shengdong Wang, Lei Qi, Junying Song, Tao Lv, Jie Bai*, Protective effect of panaxatriol saponins extracted from Panax notoginseng against MPTP-induced neurotoxicity in vivo. Journal of Ethnopharmacology, 2011. 133(2): 448-53.
    12. Fucheng Luo, Shengdong Wang, Kui Li, Hajime Nakamura, Junji Yodoi, Jie Bai*, Panaxatriol saponins extracted from Panax notoginseng induces thioredoxin-1 and prevents 1-methyl-4-phenylpyridinium ion-induced neurotoxicity. Journal of Ethnopharmacology, 2010. 127(2): 419-23.

    六、招生与招聘

    1.欢迎优秀的本科生和硕士报考实验室的硕士和博士研究生

    2.实验室招聘博士后(若干名)、助理研究员和讲师要求获得生物学博士学位,有发育神经生物学、干细胞生物学、神经电生理学、类脑器官培养或动物模型等工作经验;具有较好的研究背景,并在SCI期刊上以第一作者或通讯作者发表过较好的研究论文;具有独立研究工作能力和合作精神,善于交流,有良好的文字表达能力和协调沟通能力;有较强的英语听、说、读、写能力。

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