教授
一、教育和工作经历Education and Work Experience
2013年04月–2019年12月,上海交通大学医学院,教授、博士生导师
2008年03月–2013年03月,美国斯托瓦斯医学研究所,博士后
2004年06月–2007年12月,德国吉森大学,遗传学,博士
1998年07月–2000年05月,印度Devi Ahilya大学,生命科学,硕士
1994年07月–1997年05月,印度德里大学,植物学,学士
04-2013 -12-2019, Professor, Shanghai Jiao Tong University School of Medicine
03-2008 - 03-2013, Post Doctoral Research Associate, Stowers Institute for Medical Research, Kansas City, USA
06-2004 - 12-2007, Justus Liebig University, Giessen, Germany, PhD
07-1998 - 05-2000, Master of Sciences, Devi Ahilya Vishwavidyalaya, Indore, India
07-1994 - 05-1997 Bachelor of Sciences, University of Delhi, New Delhi, India
二、主要研究方向Main Research Directions
三、科研领域描述Description of Scientific Research
Chromosomal translocations that fuse mixed lineage leukemia 1 (MLL1) to any one of a large number of translocation partners are indicative of a poor clinical outcome in acute myeloid and lymphoid leukaemias. Up to 90% of infant leukemias bear MLL-translocations to either of the ~100 fusion gene partners. In these leukemias, MLL-fusion proteins are thought to confer biochemical activities, which promote the transcription of leukemogenic transcriptional program, including expression of HOX A9 genes, thus causing leukemia. We are investigating novel functions of the MLL-fusion proteins to understand how they cause leukemia.
Down syndrome is one of the most common genetic diseases caused by chromosomal abnormalities, including Nondisjunction, mosaicism and chromosomal translocation. DYRK1A, a gene located in Down Syndrome Critical Region on chromosome 21, is considered an important effector of some Down syndrome phenotypes. We are trying to unravel the molecular functions of DYRK1A in cellular physiology and neuronal system, using proteomics, genomics, and mouse models.
四、承担科研项目情况Research Projects
五、代表论文Representative papers
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