博士,副教授,硕士研究生导师
Ph.D., Associate professor
Email: yangnx@lpbr.cn
一、教育及工作经历 Education and Academic Positions
二、主要研究方向 Research interests
1. 免疫调控在发育过程及衰老相关疾病中的作用
2. 复杂疾病的遗传学和生物信息学研究
3. 高通量组学大数据的整合分析与数据挖掘工具开发
4. 机器学习和深度学习在生物大数据挖掘上的应用
1. exploring the role of immune regulation in developmental processes and age-related diseases
2. Genetic research and bioinformatics applied to the study of complex diseases
3. Integrated analysis of high-throughput omics data and the development of data analysis tools
4. Application of machine learning and deep learning
三、科研领域描述 Research Field
基于高通量组学数据和其他生物大数据开发生物信息学分析方法;充分发挥交叉学科优势,通过结合统计学、计算机科学、基因组学和人工智能等多学科知识探究重要的生物学问题;有机地结合计算与湿实验的优势,开展广泛的合作研究。以期揭示免疫调控在生命发育过程和疾病形成中的作用机制,为开发疾病早期筛查和治疗策略提供科学依据。
Developing bioinformatics analysis methods based on high-throughput omics data. Taking advantages of interdisciplinary research to explore important biological issues by combining multidisciplinary knowledge such as statistics, computer science, genomics and artificial intelligence. The advantages of computing and wet experiments are organically combined to carry out extensive collaborative research. In order to reveal the mechanism of immune regulation in the process of life development and disease progression, and to provide scientific basis for the development of early detection and treatment strategies of disease.
四、代表性论文 Publications
1. Naixue Yang#, Fansen Ji#, Liqing Cheng#, Jingzhe Lu#, Xiaofeng Sun, Xin Lin*, and Xun Lan*. Knockout of immunotherapy prognostic marker genes eliminates the effect of the anti-PD-1 treatment. Npj Precision Oncology. 2021 May 7;5(1):37. (IF:10.123)
2. Keyong Sun#, Runda Xu#, Fuhai Ma#, Naixue Yang#(共一),Yang Li#, Xiaofeng Sun, Peng Jin, Wenzhe Kang, Lemei Jia, Jianping Xiong, Haitao Hu, Yantao Tian*, and Xun Lan*. scRNA-seq of gastric tumor shows complex intercellular interaction with an alternative T cell exhaustion trajectory. Nature Communications. 2022 Aug 23;13(1):4943. (IF: 17.694)
3. Jihao Liang, Yang Zheng, Xin Tong, Naixue Yang*(共通讯), and Shaoxing Dai*. In Silico Identification of Anti-SARS-CoV-2 Medicinal Plants Using Cheminformatics and Machine Learning. Molecules. 2022 Dec 26;28(1):208. (IF: 4.927)
4. Liqing Cheng, Zhanqi Wei, Zaopeng Yang, Renlin Lu, Ming Yang, Muchun Yu, Naixue Yang, Shulin Li, Mingyi Gao, Xueqiang Zhao, Xin Lin*. Carma3 Protects from Liver Injury by Preserving Mitochondrial Integrity in Liver Sinusoidal Endothelial Cells. Journal of Immunology. 2022 Aug 1;209(3):456-464. (IF: 5.43)
5. Liqing Cheng, Nan Deng, Naixue Yang, Xueqiang Zhao, and Xin Lin*. 2019. Malt1 Protease Is Critical in Maintaining Function of Regulatory T Cells and May Be a Therapeutic Target for Antitumor Immunity. Journal of Immunology. 2019 May 15;202(10):3008-3019. (IF: 5.43)