一、教育经历 Education
1995年 - 1999年,云南师范大学,生命科学系,本科
2001年 - 2007年,中国科学院昆明动物研究所,博士
2006年 - 2008年,德国柏林野生与笼养动物研究所,访问学者
1.1995-1999, Yunnan Normal University, Bachelor of Biology.
2.2001-2007, Kunming Institute Of Zoology, Chinese Academy of Sciences & Zoological Research, Ph.D.
3.2006-2008, Leibniz Institute for Zoo and Wildlife Research, Visiting Scholar.
二、工作经历 Work Experience
2019年11月 -,昆明理工大学生命科学与技术学院,教授,院长
2014年12月 -,昆明理工大学灵长类转化医学研究院,教授
2011年07月 -,省部共建非人灵长类生物医学国家重点实验室,副主任
2010年09月 - 2014年05月,中科院昆明动物研究所,生殖与发育生物学实验室,副研究员
2007年04月 - 2010年09月,中科院昆明动物研究所,生殖与发育生物学实验室,助理研究员
1.2019-present, Dean and Professor, Faculty of Life Science and Technology, Kunming University of Science and Technology.
2.2014-present, Professor, Institute of Primate Translational Medicine, Kunming University of Science and Technology.
2.2011-present, Associate Director, State Key Laboratory of Primate Biomedical Research.
3.2010-2014, Associate Professor, Kunming Institute Of Zoology,Chinese Academy of Sciences & Zoological Research.
4.2007-2010, Assistant professor, Kunming Institute Of Zoology,Chinese Academy of Sciences & Zoological Research.
三、主要研究方向 Main Research Directions
灵长类基因编辑; 灵长类胚胎发育与疾病
Gene editing, Primate embryonic development
四、科研领域描述 Description of Scientific Research
早期胚胎发育是哺乳动物生命发生的重要阶段,这一时期的关键生物学事件,如合子基因启动,表观遗传维持与重建,胚层分化和器官形成等等,是发育生物学的重要基础理论,又和人类健康和疾病密切相关。然而,我们对其中的诸多科学问题却知之甚少。本实验室结合灵长类早期胚胎(体外受精,单性生殖和体细胞核移植)培养,基因编辑,干细胞与示踪,单细胞组学和灵长类疾病动物模型等技术体系,系统研究灵长类细胞多能性的维持与重建,表观遗传调控与胚层分化,退行疾病的早期诊断和干预等重要科学问题,以期揭示人类生命发生和疾病形成的奥秘。
Research in Yuyu Niu's laboratory is focused on early embryo development and reprogramming, particularly preimplantation embryo development which play an important role in cell differentiation and organ initiation, and therefore have a significant on human disease. Over the last decade, Dr. Niu has made significant contributions to non-human primate genetic engineering and early embryo development that include: 1) the first transgenic rhesus monkey in China (PNAS 2010); 2) the first monkey model with genome engineered by precision gene-targeting methods (Cell 2014; Cell 2017); 3) the continuous development of monkey embryos in vitro beyond early gastrulation and to 20 days post fertilization (Science 2019). Built on the strength in non-human primate research, the Yuyu Niu's laboratory has expanded its capability to use a variety of state-of-the-art techniques, including single cell transcriptomics, cell lineage tracing, stem cells, somatic cell nuclear transfer and CRISPR/Cas9-based genomic editing to understand the molecular events at the beginning of primate life and cell reprogramming. In addition, the lab has studied on mechanism and biomarker of neurodegeneration diseases, such as Parkinson’s disease and Amyotrophic lateral sclerosis (ALS).
五、承担科研项目情况 Research Projects
六、获奖情况
七、代表性论文(近5年) Representative papers
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