牛昱宇（Yuyu Niu）

1995年 - 1999年，云南师范大学，生命科学学院，本科

2001年 - 2007年，中国科学院昆明动物研究所，博士

2006年 - 2008年，德国柏林野生与笼养动物研究所，访问学者

1.1995-1999, Yunnan Normal University, Bachelor of Biology.

2.2001-2007, Kunming Institute Of Zoology, Chinese Academy of Sciences & Zoological Research, Ph.D.

3.2006-2008, Leibniz Institute for Zoo and Wildlife Research, Visiting Scholar.

2022年10月 - ，昆明理工大学，副校长

2019年11月 - 2022年10月，昆明理工大学生命科学与技术学院，教授，院长

2014年12月 -，昆明理工大学灵长类转化医学研究院，教授，副院长

2010年09月 - 2014年05月，中科院昆明动物研究所，副研究员

2007年04月 - 2010年09月，中科院昆明动物研究所，助理研究员

1.2022-present, Vice-Chancellor of Kunming University of Science and Technology, KUST

2.2019-2022, Dean and Professor, Faculty of Life Science and Technology, Kunming University of Science and Technology.

3.2014-present, Professor, Institute of Primate Translational Medicine, Kunming University of Science and Technology.

4.2010-2014, Associate Professor, Kunming Institute Of Zoology,Chinese Academy of Sciences & Zoological Research.

5.2007-2010, Assistant professor, Kunming Institute Of Zoology,Chinese Academy of Sciences & Zoological Research.

发育编程与疾病

Developmental programming and diseases

早期胚胎发育是哺乳动物生命发生的重要阶段，这一时期的关键生物学事件，如合子基因启动，表观遗传维持与重建，胚层分化和器官形成等等，是发育生物学的重要基础理论，又和人类健康和疾病密切相关。然而，我们对其中的诸多科学问题却知之甚少。本实验室结合灵长类早期胚胎（体外受精，单性生殖和体细胞核移植）培养，基因编辑，干细胞与示踪，单细胞组学和灵长类疾病动物模型等技术体系，系统研究灵长类细胞多能性的维持与重建，表观遗传调控与胚层分化，退行疾病的早期诊断和干预等重要科学问题，以期揭示人类生命发生和疾病形成的奥秘。

Research in Yuyu Niu's laboratory is focused on early embryo development and reprogramming, particularly preimplantation embryo development which play an important role in cell differentiation and organ initiation, and therefore have a significant on human disease. Over the last decade, Dr. Niu has made significant contributions to non-human primate genetic engineering and early embryo development that include: 1) the first transgenic rhesus monkey in China (PNAS 2010); 2) the first monkey model with genome engineered by precision gene-targeting methods (Cell 2014; Cell 2017); 3) the continuous development of monkey embryos in vitro beyond early gastrulation and to 20 days post fertilization (Science 2019). Built on the strength in non-human primate research, the Yuyu Niu's laboratory has expanded its capability to use a variety of state-of-the-art techniques, including single cell transcriptomics, cell lineage tracing, stem cells, somatic cell nuclear transfer and CRISPR/Cas9-based genomic editing to understand the molecular events at the beginning of primate life and cell reprogramming. In addition, the lab has studied on mechanism and biomarker of neurodegeneration diseases, such as Parkinson’s disease and Amyotrophic lateral sclerosis (ALS).

1. 国家重点研发计划“发育编程及其代谢调节”项目，灵长类原肠发育与器官形成的命运决定调控机制，2021-2026，3100万元
2. 国家自然科学基金联合基金项目，利用单碱基编辑技术构建早衰症猴模型及其机理研究，2022-2025，233万元
3. 国家自然科学基金面上项目，肌萎缩侧索硬化症灵长类动物转基因模型的建立及早期发病机制研究，2021-2024，58万元

1. 2008年获云南省自然科学类二等奖
2. 2012年获中国科学院卢嘉锡青年人才奖
3. 2014年获云南省青年科技奖
4. 2017年获云南省自然科学奖一等奖
5. 2021年获云南省自然科学奖一等奖
6. 2021年获全国专业技术人才先进集体
7. 2022年获云南省自然科学奖一等奖

1、发明人：牛昱宇，吴俊模，王芳，李梦佳。发明名称：一种对食蟹猴干细胞荧光示踪的方法。专利号:ZL202010135784.4。

2、发明人：牛昱宇，张磊，吴俊模。发明名称：一种小分子丝素蛋白基水凝胶及其制备方法和应用。专利号：ZL202211098853.4。

3、发明人：牛昱宇，司晨洋，吴俊模。发明名称：基于胚胎分割技术建立非人灵长类自体胚胎干细胞的方法，专利号：ZL202410668256.3。

1. WU J, SHAO T, TANG Z, LIU G, LI Z, SHI Y, KANG Y, ZUO J, ZHAO B, HU G, LIU J, JI W, ZHANG L, NIU Y. Highly efficient construction of monkey blastoid capsules from aged somatic cells [J]. Nat Commun, 2025, 16(1): 1130. (co-corresponding author)

2. YANG J, DAN J, ZHAO N, LIU L, WANG H, LIU Q, WANG L, LI J, WU Y, CHEN F, FU W, LIU F, LIN M, ZHANG W, CHEN F, LIU X, LU X, CHEN Q, WU X, NIU Y, YANG N, ZHU Y, LONG J, LIU L. Zscan4 mediates ubiquitination and degradation of the corepressor complex to promote chromatin accessibility in 2C-like cells [J]. Proc Natl Acad Sci U S A, 2024, 121(52): e2407490121. (co-corresponding author)

3. LUO X, JIA H, WANG F, MO H, KANG Y, ZHANG N, ZHAO L, XU L, YANG Z, YANG Q, CHANG Y, LI S, BIAN N, HUA X, CUI H, CAO Y, CHU C, ZENG Y, CHEN X, CHEN Z, JI W, LONG C, SONG J, NIU Y. Primate Model Carrying LMNA Mutation Develops Dilated Cardiomyopathy [J]. JACC Basic Transl Sci, 2024, 9(3): 380-95. (co-corresponding author)

4. WU J, KANG Y, LUO X, DAI S, SHI Y, LI Z, TANG Z, CHEN Z, ZHU R, YANG P, LI Z, WANG H, CHEN X, ZHAO Z, JI W, NIU Y. Long-term in vivo chimeric cells tracking in non-human primate [J]. Protein Cell, 2023. (co-corresponding author)

5. ZHU X, GUO, Y., CHU, C., LIU, D., DUAN, K., YIN, Y., SI, C., KANG, Y., YAO, J., DU, X., LI, J., ZHAO, S., AI, Z., ZHU, Q., JI, W., NIU, Y., & LI, T. BRN2 as a key gene drives the early primate telencephalon development [J]. Sci Adv, 2022 Mar 4, 8(9). (co-corresponding author)

6. LEI Y, CHENG M, LI Z, ZHUANG Z, WU L, SUN Y, HAN L, HUANG Z, WANG Y, WANG Z, XU L, YUAN Y, LIU S, PAN T, XIE J, LIU C, VOLPE G, WARD C, LAI Y, XU J, WANG M, YU H, SUN H, YU Q, WU L, WANG C, WONG C W, LIU W, XU L, WEI J, CHEN D, SHANG Z, LI G, MA K, CHENG L, LING F, TAN T, CHEN K, TASIC B, DEAN M, JI W, YANG H, GU Y, ESTEBAN M A, LI Y, CHEN A, NIU Y, ZENG H, HOU Y, LIU L, LIU S, XU X. Spatially resolved gene regulatory and disease-related vulnerability map of the adult Macaque cortex [J]. Nat Commun, 2022, 13(1): 6747. (co-corresponding author)

7. KANG Y, DAI, S., ZENG, Y., WANG, F., YANG, P., YANG, Z., PU, Y., LI, Z., CHEN, X., TIAN, B., SI, W., JI, W., & NIU, Y. Cloning and base editing of GFP transgenic rhesus monkey and off-target analysis [J]. Sci Adv, 2022, 8(29): eabo3123. (co-corresponding author)

8. ZHONG T, WEI, J., WU, K., CHEN, L., ZHAO, F., PEI, Y., WANG, Y., ZHANG, H., WU, Z., HUANG, Y., LI, T., WANG, L., CHEN, Y., JI, W., ZHANG, Y., LI, G., & NIU,Y. Longitudinal brain atlases of early developing cynomolgus macaques from birth to 48 months of age [J]. Neuroimage, 2021, 247: 118799. (co-corresponding author)

9. YANG R, GOEDEL, A., KANG, Y., SI, C., CHU, C., ZHENG, Y., CHEN, Z., GRUBER, P. J., XIAO, Y., ZHOU, C., WITMAN, N., EROGLU, E., LEUNG, C. Y., CHEN, Y., FU, J., JI, W., LANNER, F., NIU, Y., & CHIEN, K. R. Amnion signals are essential for mesoderm formation in primates [J]. Nat commun, 2021, 12(1): 1-14. (co-corresponding author)

10. TAN T, WU, J., SI, C., DAI, S., ZHANG, Y., SUN, N., ZHANG, E., SHAO, H., SI, W., YANG, P., WANG, H., CHEN, Z., ZHU, R., KANG, Y., HERNANDEZ-BENITEZ R, MARTINEZ MARTINEZ L, NUÑEZ DELICADO E, BERGGREN WT, SCHWARZ M, AI Z, LI T, RODRIGUEZ ESTEBAN C., JI, W., NIU, Y., &IZPISUA BELMONTE JC. Chimeric contribution of human extended pluripotent stem cells to monkey embryos ex vivo [J]. Cell, 2021, 184(8): 2020-32 e14. (co-corresponding author)

11. CHU C, ZHANG, W., KANG, Y., SI, C., JI, W., NIU, Y., ZHANG, Y. Analysis of developmental imprinting dynamics in primates using SNP-free methods to identify imprinting defects in cloned placenta [J]. Developmental cell, 2021, 56(20): 2826-40. e7. (co-corresponding author)

12. CHEN C, JI, W., NIU, Y. Primate Organoids and Gene-Editing Technologies toward Next-Generation Biomedical Research [J]. Trends in Biotechnology, 2021. (co-corresponding author)