• 牛昱宇(Yuyu Niu)

    教授
    灵长类转化医学研究院 副院长
    云南中科灵长类生物医学重点实验室 副主任
    Professor

    Associate Director Of Yunnan Key Laboratory of Primate Biomedical Research

    、教育经历 Education

    1995年-1999年,云南师范大学,生命科学系,本科

    2001年-2007年,中科院昆明动物研究所,博士
    2006年-2008年,德国柏林野生与笼养动物研究所,访问学者

     

    1.1995-1999, Yunnan Normal University, Bachelor ofBiology.

    2.2001-2007, Kunming Institute Of Zoology,Chinese Academy of Sciences & Zoological Research, Ph.D.

    3.2006-2008, Leibniz Institute for Zoo and Wildlife Research, Visiting Scholar.

     

    二、工作经历 Work Experience

    2014年12月-,昆明理工大学灵长类转化医学研究院,教授
    2011年07月-,云南省灵长类生物医学重点实验室,生物医学动物模型国家地方联合工程研究中心,副主任,研究员
    2010年09月-2014年05月,中科院昆明动物研究所,生殖与发育生物学实验室,副研究员
    2007年04月-2010年09月,中科院昆明动物研究所,生殖与发育生物学实验室,助理研究员

     

    1.2014–present, Professor, Institute of Primate Translational Medicine, Kunming University of Science and Technology.

    2.2011–present, Associate Director, Yunnan Key Laboratory of Primate Biomedical Research.

    3.2010-2014,Associate Professor, Kunming Institute Of Zoology,Chinese Academy of Sciences & Zoological Research.

    4.2007–2010, Assistant professor, Kunming Institute Of Zoology,Chinese Academy of Sciences & Zoological Research.

    三、主要研究方向 Main Research Directions

    1. 基因编辑
    2. 灵长类胚胎发育与神经退行性疾病
    1. Gene editing
    2. Primate embryonic development
    3. Neurodegenerative disease

    四、科研领域描述 Description of Scientific Research

       以非人灵长类为模式动物,探索灵长类早期发育与神经退行疾病的机制,结合靶向基因编辑和干细胞技术开展疾病治疗的研究。2014年作为核心成员成功运用基因编辑技术,实现了灵长类动物的靶向基因修饰,获得了世界首只经过基因靶向修饰的基因工程猴。研究成果以第一作者在 Cell 杂志发表,引起全球科学界和主流媒体的关注,Nature 杂志将这一研究成果称为人类疾病模型研究发展的里程碑并被入选2014成功科学事件之一。该文章不仅入选 Cell 2014年十篇最受关注论文,也是迄今为止该杂志前5%高关注度学术文章。至今在Cell,Cell Stem Cell和PNAS等杂志以第一作者或通讯作者发表SCI论文30余篇。曾获中科院卢嘉锡青年奖和云南省青年科技奖。作为课题负责人承担过863和973课题,目前承担有国家自然基金联合基金项目1项。2016年,作为首席科学家承担国家重点研发计划“干细胞及转化研究”重点专项项目1项。

     

       Using non-human primates as model animals, Dr. Yuyu Niuexpected to explore the mechanisms of primate early development and neurodegenerative diseases.Meanwhile,combined with gene editing and stem cell technology,conducted disease treatment research. In 2014, Dr. Yuyu Niu successfully applied gene editing technology to achieve targetedgene modification ofnon-human primates. He was the core member of the project and published the research resultsin Cell magazine,which attracted the attention of the global scientific community and mainstream media. Nature magazine called this research a milestone in the development of human disease model research and was selected as one of the successful scientific events in 2014. The article was not only selected as the ten most popular papers in Cell 2014, but also the top 5% of the magazine's high-profile academic articles to date.

       Dr. Yuyu Niuhave published more than 30 SCI papers, including the magazines Cell, Cell Stem Cell and PNAS. He was awarded the Lu Jiaxi Youth Award and the Yunnan Youth Science and Technology Award. As the project leader,he has undertaken the 863 and 973 projects. In 2016, as the chief scientist, he undertook the “Stem Cell and Transformation Research”Special Funds of National Key Research and Development Project.

    五、承担科研项目情况 Research Projects

    1. 国家重点研发计划“干细胞及转化研究”专项项目,2016YFA0101400,靶向基因编辑建立神经系统疾病猴模型及干细胞治疗研究,2016-2012,2915万元,首席科学家。
    2. 国家自然科学基金联合重点项目,U1302227,帕金森氏症转基因灵长类动物模型的构建与致病机理研究,2014-2017,210万元,项目负责人
    3. 国家重大科学研究计划(973计划),2012CBA01304,神经退行疾病致病机理及转基因动物模型的建立,2012/01-2016/12,420万元,课题负责人。
    4. 国家高技术研究发展计划(863计划),2012AA020701,神经退行性疾病灵长类动物模型制备关键技术及利用,2012/01-2015/12,710万元,课题负责人。
    5. 国家科技重大专项,2009ZX09501-028,评价抗HCV 化学药物疗效和安全性的动物模型,2009/01-2011/12,690万元,已结题,项目负责人。
    1. “Stem Cell and Transformation Research”Special Funds of National Key Research and Development Project:2016YFA0101400. Research onUsing Targeted Gene Editing to Establish a Neurological Diseases and Stem Cell TherapyMonkey Model.2016-2020.Chief scientist.
    2. Joint Funds of the National Natural Science Foundation of Chinaproject:U1302227.Research onconstruction and pathogenesis of transgenic primate model of Parkinson's disease.2014-2017.Principal Investigator.
    3. National Program on Key Basic Research Project of China (973 Program):2012CBA01304.Pathogenesis of neurodegenerative diseases and establishment of transgenic animal models.2012/01-2016/12.Project leader.
    4. National High-tech R&D Program of China (863 Program):2012AA020701.Key techniques and utilization oftransgenic primate model of Parkinson's disease.2012/01-2015/12.Project leader.
    5. National Science and Technology Major Project:2009ZX09501-028.Research on evaluating the efficacy and safety of anti-HCV chemicals in animal model.2009/01-2011/12,Project completed.Principal Investigator.

    六、获奖情况

    1. 2008年获云南省科学技术奖自然科学类二等奖
    2. 2012年获中国科学院卢嘉锡青年人才奖
    3. 2014年获云南省青年科技奖

    七、代表性论文 Representative papers

    1. Gao, F., Niu, Y., Sun, Y.E., Lu, H., Chen, Y., Li, S., Kang, Y., Luo, Y., Si, C., Yu, J., et al. (2017). De novo DNA methylation during monkey pre-implantation embryogenesis. Cell research. doi: 10.1038/cr.2017.25.
    2. Chen, Y., Niu, Y., and Ji, W. (2016). Genome editing in nonhuman primates: approach to generating human disease models. Journal of internal medicine 280, 246-251.
    3. Wan, H., Feng, C., Teng, F., Yang, S., Hu, B., Niu, Y., Xiang, A.P., Fang, W., Ji, W., Li, W., et al. (2015). One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system. Cell research 25, 258-261.
    4. Niu, Y., Guo, X., Chen, Y., Wang, C.E., Gao, J., Yang, W., Kang, Y., Si, W., Wang, H., Yang, S.H., et al. (2015). Early Parkinson's disease symptoms in alpha-synuclein transgenic monkeys. Human molecular genetics 24, 2308-2317.  2015-4-15
    5. Kang, Y., Zheng, B., Shen, B., Chen, Y., Wang, L., Wang, J., Niu, Y., Cui, Y., Zhou, J., Wang, H., et al. (2015). CRISPR/Cas9-mediated Dax1 knockout in the monkey recapitulates human AHC-HH. Human molecular genetics 24, 7255-7264.
    6. Chen, Y., Zheng, Y., Kang, Y., Yang, W., Niu, Y., Guo, X., Tu, Z., Si, C., Wang, H., Xing, R., et al. (2015). Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9. Human molecular genetics 24, 3764-3774. 2015-4-11
    7. Niu, Y., Shen, B., Cui, Y., Chen, Y., Wang, J., Wang, L., Kang, Y., Zhao, X., Si, W., Li, W., et al. (2014). Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos. Cell 156, 836-843.
    8. Liu, H., Chen, Y., Niu, Y., Zhang, K., Kang, Y., Ge, W., Liu, X., Zhao, E., Wang, C., Lin, S., et al. (2014). TALEN-mediated gene mutagenesis in rhesus and cynomolgus monkeys. Cell stem cell 14, 323-328.
    9. Fan, Y., Huang, Z.Y., Cao, C.C., Chen, C.S., Chen, Y.X., Fan, D.D., He, J., Hou, H.L., Hu, L., Hu, X.T., et al. (2013). Genome of the Chinese tree shrew. Nature communications 4, 1426.
    10. Chen, Y., Niu, Y., and Ji, W. (2012). Transgenic nonhuman primate models for human diseases: approaches and contributing factors. Journal of genetics and genomics 39, 247-251.
    11. Niu, Y., Yu, Y., Bernat, A., Yang, S., He, X., Guo, X., Chen, D., Chen, Y., Ji, S., Si, W., et al. (2010). Transgenic rhesus monkeys produced by gene transfer into early-cleavage-stage embryos using a simian immunodeficiency virus-based vector. Proceedings of the National Academy of Sciences of the United States of America 107, 17663-17667.
    12. Niu, Y., Yang, S., Yu, Y., Ding, C., Yang, J., Wang, S., Ji, S., He, X., Xie, Y., Tang, X., et al. (2008). Impairments in embryonic genome activation in rhesus monkey somatic cell nuclear transfer embryos. Cloning and stem cells 10, 25-36.
    13. Yang, J., Yang, S., Beaujean, N., Niu, Y., He, X., Xie, Y., Tang, X., Wang, L., Zhou, Q., and Ji, W. (2007). Epigenetic marks in cloned rhesus monkey embryos: comparison with counterparts produced in vitro. Biology of reproduction 76, 36-42.
    14. Wang, S., Tang, X., Niu, Y., Chen, H., Li, B., Li, T., Zhang, X., Hu, Z., Zhou, Q., and Ji, W. (2007). Generation and characterization of rabbit embryonic stem cells. Stem cells 25, 481-489.
    15. Niu, Y., Greube, A., Ji, W., and Jewgenow, K. (2006). The application of in vitro sperm competition test to evaluate the impact of ZP-derived peptides on fertilization capacity of cat sperm. Theriogenology 66, 989-995.
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