• 牛昱宇(Yuyu Niu)

    长江学者特聘教授,博士生导师
    昆明理工大学生命科学与技术学院 院长
    昆明理工大学灵长类转化医学研究院 副院长
    省部共建非人灵长类生物医学国家重点实验室 副主任
     
    Dean&Professor of Faculty of Life Science and Technology, KUST
    Associate Director and Professor of Institute of Primate Translational Medicine, KUST

    、教育经历 Education

    1995年-1999年,云南师范大学,生命科学系,本科

    2001年-2007年,中国科学院昆明动物研究所,博士
    2006年-2008年,德国柏林野生与笼养动物研究所,访问学者

     

    1.1995-1999, Yunnan Normal University, Bachelor of Biology.

    2.2001-2007, Kunming Institute Of Zoology, Chinese Academy of Sciences & Zoological Research, Ph.D.

    3.2006-2008, Leibniz Institute for Zoo and Wildlife Research, Visiting Scholar.

     

    二、工作经历 Work Experience

    2019年11月-,昆明理工大学生命科学与技术学院,教授,院长

    2014年12月-,昆明理工大学灵长类转化医学研究院,教授,副院长
    2011年07月-,云南省灵长类生物医学重点实验室,生物医学动物模型国家地方联合工程研究中心,副主任,研究员
    2010年09月-2014年05月,中科院昆明动物研究所,生殖与发育生物学实验室,副研究员
    2007年04月-2010年09月,中科院昆明动物研究所,生殖与发育生物学实验室,助理研究员

     

    1.2019-present, Dean and Professor, Faculty of Life Science and Technology, Kunming University of Science and Technology.

    2.2014-present, Professor, Institute of Primate Translational Medicine, Kunming University of Science and Technology.

    2.2011-present, Associate Director, Yunnan Key Laboratory of Primate Biomedical Research.

    3.2010-2014,Associate Professor, Kunming Institute Of Zoology,Chinese Academy of Sciences & Zoological Research.

    4.2007-2010, Assistant professor, Kunming Institute Of Zoology,Chinese Academy of Sciences & Zoological Research.

    三、主要研究方向 Main Research Directions

    1. 灵长类基因编辑
    2. 灵长类胚胎发育与疾病
    1. Gene editing
    2. Primate embryonic development
    3. Neurodegenerative disease

    四、科研领域描述 Description of Scientific Research

       早期胚胎发育是哺乳动物生命发生的重要阶段,这一时期的关键生物学事件,如合子基因启动,表观遗传维持与重建,胚层分化和器官形成等等,是发育生物学的重要基础理论,又和人类健康和疾病密切相关。然而,我们对其中的诸多科学问题却知之甚少。本实验室结合灵长类早期胚胎(体外受精,单性生殖和体细胞核移植)培养,基因编辑,干细胞与示踪,单细胞组学和灵长类疾病动物模型等技术体系,系统研究灵长类细胞多能性的维持与重建,表观遗传调控与胚层分化,退行疾病的早期诊断和干预等重要科学问题,以期揭示人类生命发生和疾病形成的奥秘。


    Research in Yuyu Niu's laboratory is focused on early embryo development and reprogramming, particularly preimplantation embryo development which play an important role in cell differentiation and organ initiation, and therefore have a significant on human disease. Over the last decade, Dr. Niu has made significant contributions to non-human primate genetic engineering and early embryo development that include: 1) the first transgenic rhesus monkey in China (PNAS 2010); 2) the first monkey model with genome engineered by precision gene-targeting methods (Cell 2014; Cell 2017); 3) the continuous development of monkey embryos in vitro beyond early gastrulation and to 20 days post fertilization (Science 2019). Built on the strength in non-human primate research, the Yuyu Niu's laboratory has expanded its capability to use a variety of state-of-the-art techniques, including single cell transcriptomics, cell lineage tracing, stem cells, somatic cell nuclear transfer and CRISPR/Cas9-based genomic editing to understand the molecular events at the beginning of primate life and cell reprogramming. In addition, the lab has studied on mechanism and biomarker of neurodegeneration diseases, such as Parkinson’s disease and Amyotrophic lateral sclerosis (ALS).

    五、承担科研项目情况 Research Projects

    1. 国家重点研发计划“干细胞及转化研究”专项项目,2016YFA0101400,靶向基因编辑建立神经系统疾病猴模型及干细胞治疗研究,2016-2012,2915万元,首席科学家。
    2. 国家自然科学基金联合重点项目,U1302227,帕金森氏症转基因灵长类动物模型的构建与致病机理研究,2014-2017,210万元,项目负责人
    3. 国家重大科学研究计划(973计划),2012CBA01304,神经退行疾病致病机理及转基因动物模型的建立,2012/01-2016/12,420万元,课题负责人。
    4. 国家高技术研究发展计划(863计划),2012AA020701,神经退行性疾病灵长类动物模型制备关键技术及利用,2012/01-2015/12,710万元,课题负责人。
    5. 国家科技重大专项,2009ZX09501-028,评价抗HCV 化学药物疗效和安全性的动物模型,2009/01-2011/12,690万元,已结题,项目负责人。
    1. “Stem Cell and Transformation Research”Special Funds of National Key Research and Development Project:2016YFA0101400. Research onUsing Targeted Gene Editing to Establish a Neurological Diseases and Stem Cell TherapyMonkey Model.2016-2020.Chief scientist.
    2. Joint Funds of the National Natural Science Foundation of Chinaproject:U1302227.Research onconstruction and pathogenesis of transgenic primate model of Parkinson's disease.2014-2017.Principal Investigator.
    3. National Program on Key Basic Research Project of China (973 Program):2012CBA01304.Pathogenesis of neurodegenerative diseases and establishment of transgenic animal models.2012/01-2016/12.Project leader.
    4. National High-tech R&D Program of China (863 Program):2012AA020701.Key techniques and utilization oftransgenic primate model of Parkinson's disease.2012/01-2015/12.Project leader.
    5. National Science and Technology Major Project:2009ZX09501-028.Research on evaluating the efficacy and safety of anti-HCV chemicals in animal model.2009/01-2011/12,Project completed.Principal Investigator.

    六、获奖情况

    1. 2008年获云南省自然科学类二等奖
    2. 2012年获中国科学院卢嘉锡青年人才奖
    3. 2014年获云南省青年科技奖
    4. 2017年获云南省自然科学奖一等奖

    七、代表性论文 Representative papers

    1. Niu, Y., Sun, N., Li, C., Lei, Y., Huang, Z., Wu, J., Si, C., Dai, X., Liu, C., and Wei, J. (2019). Dissecting primate early post-implantation development using long-term in vitro embryo culture. Science 366.
    2. Chen, Y., Yu, J., Niu, Y., Qin, D., Liu, H., Li, G., Hu, Y., Wang, J., Lu, Y., and Kang, Y. (2017). Modeling Rett syndrome using TALEN-edited MECP2 mutant cynomolgus monkeys. Cell 169, 945-955. e910.
    3. Niu, Y., Li, T., and Ji, W. (2017). Paving the road for biomedicine: genome editing and stem cells in primates. National Science Review 4, 543-549.
    4. Niu, Y., Guo, X., Chen, Y., Wang, C.E., Gao, J., Yang, W., Kang, Y., Si, W., Wang, H., Yang, S.H., et al. (2015). Early Parkinson's disease symptoms in alpha-synuclein transgenic monkeys. Human molecular genetics 24, 2308-2317.
    5. Chen, Y., Niu, Y., Li, Y., Ai, Z., Kang, Y., Shi, H., Xiang, Z., Yang, Z., Tan, T., and Si, W. (2015). Generation of cynomolgus monkey chimeric fetuses using embryonic stem cells. Cell stem cell 17, 116-124.
    6. Niu, Y., Shen, B., Cui, Y., Chen, Y., Wang, J., Wang, L., Kang, Y., Zhao, X., Si, W., Li, W., et al. (2014). Generation of gene-modified cynomolgus monkey via Cas9/RNA-mediated gene targeting in one-cell embryos. Cell 156, 836-843.
    7. Liu, H., Chen, Y., Niu, Y., Zhang, K., Kang, Y., Ge, W., Liu, X., Zhao, E., Wang, C., Lin, S., et al. (2014). TALEN-mediated gene mutagenesis in rhesus and cynomolgus monkeys. Cell stem cell 14, 323-328.
    8. Niu, Y., Yu, Y., Bernat, A., Yang, S., He, X., Guo, X., Chen, D., Chen, Y., Ji, S., Si, W., et al. (2010). Transgenic rhesus monkeys produced by gene transfer into early-cleavage-stage embryos using a simian immunodeficiency virus-based vector. Proceedings of the National Academy of Sciences of the United States of America 107, 17663-17667.
    9. Niu, Y., Yang, S., Yu, Y., Ding, C., Yang, J., Wang, S., Ji, S., He, X., Xie, Y., Tang, X., et al. (2008). Impairments in embryonic genome activation in rhesus monkey somatic cell nuclear transfer embryos. Cloning and stem cells 10, 25-36.
    10. Yang, J., Yang, S., Beaujean, N., Niu, Y., He, X., Xie, Y., Tang, X., Wang, L., Zhou, Q., and Ji, W. (2007). Epigenetic marks in cloned rhesus monkey embryos: comparison with counterparts produced in vitro. Biology of reproduction 76, 36-42.
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