客座教授

一、受教育及工作经历 Education and Working Experience

• 2004.9 – 2008.6，清华大学，工程力学与航天航空工程，学士
• 2008.9 – 2011.6，清华大学，固体力学，硕士
• 2011.9 – 2016.12，美国密歇根大学，       机械工程，生物力学方向，博士
• 2017.1 – 2017.6，美国密歇根大学，机械工程系，博士后
• 2017.8 – 2019.5，美国麻省理工学院，哈佛医学院，博士后
• 2019.9 – 至今，清华大学，工程力学系，生物力学与医学工程研究所，副教授
• 2021.1 – 至今，昆明理工大学，灵长类转化医学研究院，客座教授

• 2004.9 – 2008.6, Bachelor’s Degree, Department of Engineering Mechanics, Tsinghua University
• 2008.9 – 2011.6, Master’s Degree, Department of Engineering Mechanics, Tsinghua University
• 2011.9 – 2016.12, Ph.D., University of Michigan, Department of Mechanical Engineering
• 2017.1 – 2017.6, Postdoc, University of Michigan, Department of Mechanical Engineering
• 2017.8 – 2019.5, Postdoc, Koch Institute of Integrative Cancer Research, MIT
• 2019.9 – now, Tsinghua University, Department of Engineering Mechanics, Institute of Biomechanics and Medical Engineering, Associate Professor     
• 2021.1 – now, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Adjunct Professor

二、主要研究方向 Research Interests

1.  胚胎、器官与组织的体外发生及制造
2.  细胞命运与功能的工程调控与机理研究
3. 材料生物学与生物力学

1. Ectogenesis of tissues, organs, and embryos
2. Engineered control of cell fates and functions
3. Biological effects of materials and mechanics

三、承担项目情况 Research Projects and Grants

• 海外高层次人才引进计划 Oversea High-level Scholar Introduction Program

四、获奖情况 Awards

1. 2020年《麻省理工科技评论》“35岁以下科技创新35人”中国榜单
2. 2020年微系统与纳米工程青年科学家奖

1. MIT Technology Review “Innovators Under 35 China” 2020
2. Microsystems and Nanoengineering Summit 2020, Young Scientist Award

五、代表性论文

(^# 共同一作；* 通讯作者)

1. Kiranj K. Chaudagar, Natalie Landon-Brace, Aniruddh Solanki, Hanna M. Hieromnimon, Emma Hegermiller, Wen Li, Yue Shao, John Joseph, Devan J. Wilkins, Kaela M. Bynoe, Xiang-Ling Li, John G. Clohessy, Soumya Ullas, Jeffrey M. Karp, and Akash Patnaik. Cabozantinib unlocks efficient in vivo targeted delivery of neutrophil-loaded nanoparticles into murine prostate tumors. Molecular Cancer Therapeutics, vol. 20, 438-449, 2021
2. Yi Zheng, Yue Shao, and Jianping Fu. A microfluidics-based stem cell model of early post-implantation human development. Nature Protocols, vol. 16, 309-326, 2021
3. Ryan F. Townshend^#, Yue Shao^#, Sicong Wang, Chari L. Cortez, Sajedeh Nasr Esfahani, Jason R. Spence, K. Sue O’Shea, Jianping Fu, Deborah L. Gumucio, and Kenichiro Taniguchi. Effect of cell spreading on rosette formation by human pluripotent stem cell-derived neural progenitor cells. Frontiers in Cell and Developmental Biology, vol. 8, 588941, 2020
4. Yue Shao^*, Jianping Fu. Synthetic human embryology: Towards a quantitative future. Current Opinion in Genetics and Development, vol. 63, 30-35, 2020
5. Yuanyuan Zheng, Xufeng Xue, Agnes M. Resto Irizarry, Zida Li, Yue Shao, Yi Zheng, Gang Zhao, and Jianping Fu. Dorsal-ventral patterned neural cyst from human pluripotent stem cells in a biomimetic neurogenic niche. Science Advances, vol. 5, eaax5933, 2019
6. Yi Zheng, Xufeng Xue, Yue Shao, Sicong Wang, Sajedeh Nasr Esfahani, Zida Li, Jonathon M. Muncie, Johnathon N. Lakins, Valerie M. Weaver, Deborah L. Gumucio, and Jianping Fu. Controlled modelling of human epiblast and amnion development using stem cells. Nature, vol. 573, 421-425, 2019
7. Sajedeh Nasr Esfahani^#, Yue Shao^#, Agnes M. Resto Irizarry, Zida Li, Xufeng Xue, Deborah L. Gumucio, and Jianping Fu. Microengineered human amniotic ectoderm tissue array for high-content developmental phenotyping. Biomaterials, vol. 216, 119244, 2019.
8. Xufeng Xue, Yubing Sun, Agnes Resto-Irizarry, Ye Yuan, Koh Meng Aw Yong, Yi Zheng, Shinuo Weng, Yue Shao, Yimin Chai, Lorenz Studer, and Jianping Fu. Mechanics-guided embryonic patterning of neuroectoderm tissue from human pluripotent stem cells. Nature Materials, vol. 17, 633-641, 2018.
9. Yue Shao^#, Kenichiro Taniguchi^#, Ryan F. Townshend, Toshio Miki, Deborah L. Gumucio, and Jianping Fu. A pluripotent stem cell-based model for post-implantation human amniotic sac development. Nature Communications, vol. 8, 208, 2017.
10. Yue Shao^#, Kenichiro Taniguchi^#, Katherine Gurdziel, Ryan F. Townshend, Xufeng Xue, Koh Meng Aw Yong, Jianming Sang, Jason R. Spence, Deborah L. Gumucio, and Jianping Fu. Self-organized amniogenesis by human pluripotent stem cells in a biomimetic implantation-like niche. Nature Materials, vol. 16, 419-425, 2017.
11. Shinuo Weng^#, Yue Shao^#, Weiqiang Chen, and Jianping Fu. Mechanosensitive subcellular rheostasis drives emergent single-cell mechanical homeostasis. Nature Materials, vol. 15, 961-967, 2016.
12. Yi Zheng, Yubing Sun, Xinwei Yu, Yue Shao, Ping Zhang, Guohao Dai, and Jianping Fu. Angiogenesis in liquid tumors: An in-vitro assay for leukemic cell induced bone marrow angiogenesis. Advanced Healthcare Materials, vol. 5, 1014-1024, 2016.
13. Yue Shao^#, Jianming Sang^#, and Jianping Fu. On human pluripotent stem cell control: The rise of 3D bioengineering and mechanobiology. Biomaterials, vol. 52, 26-43, 2015.
14. Weiqiang Chen^#, Yue Shao^#, Xiang Li, Gang Zhao, and Jianping Fu. Nanotopographical surfaces for stem cell fate control: Engineering mechanobiology from the bottom. Nano Today, vol. 9, 759-784, 2014.
15. Yue Shao, Jennifer M. Mann, Weiqiang Chen, and Jianping Fu. Global architecture of the F-actin cytoskeleton regulates cell shape-dependent endothelial mechanotransduction. Integrative Biology, vol. 6, 300-311, 2014.
16. Yue Shao, and Jianping Fu. Integrated micro/nanoengineered functional biomaterials for cell mechanics and mechanobiology: a materials perspective. Advanced Materials, vol. 26, 1494-1533, 2014.
17. Yue Shao^#, Xinyu Tan^#, Roman Novitski, Misha Muqaddam, Paul T. List, Laura Williamson, Jianping Fu, and Allen P. Liu. Uniaxial cell stretching device for live-cell imaging of mechanosensitive cellular functions. Review of Scientific Instruments, vol. 84, 114304, 2013.