Ph.D., Professor, Doctoral supervisor,
Young and middle-aged academic and technological leader of Yunnan.
一、受教育及工作经历 EDUCATION AND WORK EXPERIENCE
2002.9-2006.7 博士研究生(获理学博士学位),导师:宿兵研究员
Ph.D. in Human Population Genetics (Chinese Academy of Sciences) 2006 State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology and Kunming Primate Research Centre, CAS
Supervisor: Professor Bing Su (Comparative genomic Group)
M.Sc. in Genetics (Yunnan University) 2002 Human Genetics Centre, Yunnan University
Supervisor: Professor Chun-jie Xiao
B.Sc. in Aquaculture (Southwest Agriculture University) 1996
Fishery department, Southwest Agriculture University (Southwest University)
Professor (2015--present)
Principal investigator, primate genetic diversity and personalized medicine.
Institute of primate translational medicine, Kunming University of Science and Technology.
Associate Professor (2009-2014)
State Key Laboratory of Genetic Resources and Evolution,
Kunming Institute of Zoology and Kunming Primate Research Centre, CAS
Assistant Research Fellow (2006-2009)
State Key Laboratory of Genetic Resources and Evolution,
Kunming Institute of Zoology and Kunming Primate Research Centre, CAS
二、研究工作经历
三、研究经历
Human population genetics
The origin and prehistoric migration of the modern humans in East Asia is an interesting question. Research was performed by Y chromosome, mtDNA and autosomal markers.
Adaptation evolution of the East Asians under the environmental stresses
East Asians are the most widely dispersed populations. They distributed from the tropic regions to the polar regions (from Indonesia to Siberia) and from low altitude coastal lands to the Tibet Plateau (3,500-5,000 meters high). East Asian populations dispersed in the continent and met different environmental stress changes during the recent tens of thousands of years.
There had the huge changes in East Asian populations, such as adaptation evolution of p53 pathway under environmental stresses; adaptation evolution of hypoxia in Tibetan populations; adaptation evolution of the skin color in East Asians; natural selection of malaria in East Asians; the genetic susceptibility of tropical and subtropical zone diseases in the southwestern populations of China.
RESEARCH INTERESTING
Adaptation evolution of the East Asians
My research in this part is aimed to answer the questions about what kinds of genetic changes resulted in the adaptation evolution of East Asians to meet different environmental stresses.
The genetic differences among populations with different adaptive characteristics are detected at genome level. Combining analysis with function pathways, the functional mutations of genes are searched, and the key mutations that regulate the evolution of environmental adaptation in modern populations are found. The molecular evolution model of the candidate gene is constructed among populations, and the effect of natural selection on gene evolution is evaluated. Based the genetic correlation analysis to find key mutations related to environmental adaptation phenotype, further functional analysis of candidate genes is carried out to reveal the molecular evolutionary mechanism of environmental adaptation, and to explore its molecular mechanism and functional consequences at cellular level and animal model.
At present, studies focus on the analysis of skin color adaptability and the molecular mechanism of adaptive evolution of anti-malaria in East Asian populations. To systematically answer how adaptive phenotype evolved through genetic variation and physiological function change, and to explore the effects of environmental selection and lifestyle changes on the genetic structure of East Asian populations.
Population cohort and precision medicine in southwestern China
There have a large number of ethnic groups in Southwest China and the natural environment is complex and changeable. Through long-term adaptive evolution, populations have formed many genetic variation characteristics. It is an ideal place to study human genetic diversity and characteristic diseases of regional populations.
The molecular mechanism of adaptation can help understand the evolution history of human population, the susceptibility of population to diseases, the sensitivity of population to drugs, and the interaction between genetic variation and environmental factors.
The cohort study of natural populations is important to development of precision medicine. Southwest China has special diseases such as thalassemia, glucose-6-phosphate dehydrogenase deficiency, congenital heart disease and pulmonary hypertension. This study will explore the relationship between disease phenotypes and genetic variations in the populations of Southwest China, and provide genetic data support for disease treatment and prevention.
Primate genetic diversity and personalized medicine
The genetic similarities, differences and biological effects between human with non-human primates at the genome-wide level are compared, and analyze the relationship between genetic polymorphism and phenotype of non-human primates at the population level. It will provide basic data for animal models of diseases and pre-clinical research of personalized medicine. The abundant genetic polymorphisms in non-human primate genomes can be used to analyze the effects of mutations on drug metabolism in pre-clinical practice.
四、主持和参与基金 FUNDS AWARD
1. Integration Project of Natural Science Foundation of China (NSFC) (91631303)¥10,000,000.00
My position: Project Backbone
2018-2019(Project title: The impact of admixture on genome diversity in East Asian and South Asian populations)
2. Integration Project of Natural Science Foundation of China (NSFC) (91631307)¥2,880,000.00
My position: Project Backbone
2017-2019(Project title: The evolution and genetic mechanisms of pigmentation related phenotypes in East Asian and European populations)
3. General grant of National Science Foundation of China (NSFC) (31371268)¥1,000,000.00
My position: Principal Investigator
2014-2017(Project title: Genetic adaptation of anti-Malaria in East Asian populations)
4. Key project of National Science Foundation of China (NSFC) (91131001)¥1,000,000.00
My position: Principal Investigator
2012-2014(Project title: The genetic variations of adaptation evolution in East Asians)
5. General grant of National Science Foundation of China (NSFC) (31071101)¥380,000.00
My position: Principal Investigator
2011-2013(Project title: The human evolution of MDMX under the environmental stress)
6. General grant of National Science Foundation of China (NSFC) (30700445)¥170,000.00
My position: Principal Investigator
2008-2010(Project title: The Y chromosome haplogroup D and the origin of East Asian)
7. Grant for doctors of west districts, CAS foundation ¥200,000.00
My position: Principal Investigator
2008-2010(Project title: The adaptation evolution of the p53 pathway under the Environmental Stresses)
五、奖励情况 HONORS
六、代表性论文 PUBLICATIONS
1.Zhaohui Yang†, Hong Shi†, Pengcheng Ma†, Shilei Zhao, Qinghong Kong, Tianhao Bian, Chao Gong, Qi Zhao, Yuan Liu, Xuebin Qi, Xiaoming Zhang, Yinglun Han, Jiewei Liu, Qingwei Li, Hua Chen,* and Bing Su*. Darwinian Positive Selection on the Pleiotropic Effects of KITLG Explain Skin Pigmentation and Winter Temperature Adaptation in Eurasians. Mol Biol Evol. 2018, 35(9):2272-2283. (DOI: 10.1093/molbev/ msy136) (IF:10.217)
2.Sushil Bhandari,Xiaoming Zhang,Chaoying Cui, Yangla,Lan Liu, Ouzhuluobu, Baimakangzhuo, Gonggalanzi,Caijuan Bai, Bianba,Yi Peng,Hui Zhang,Kun Xiang,Hong Shi,Shiming Liu, Gengdeng,Tianyi Wu,Xuebin Qi,Bing Su. Sherpas share genetic variations with Tibetans for high-altitude adaptation. Mol Genet & Genom Med. 2017 JAN 5 (1): 76-84. (DOI: 10.1002/mgg3.264)
3.Zhaohui Yang, Hua Zhong, Jing Chen, Xiaoming Zhang, Hui Zhang, Xin Luo, Shuhua Xu, Hua Chen, Dongsheng Lu, Yinglun Han, Jinkun Li, Lijie Fu, Xuebin Qi, Yi Peng, Kun Xiang, Qiang Lin, Yan Guo, Ming Li, Xiangyu Cao, Yanfeng Zhang, Shiyu Liao, Yingmei Peng, Lin Zhang, Xiaosen Guo, Shanshan Dong, Fan Liang, Jun Wang, Andrew Willden, Hong Seang Aun, Bun Serey, Tuot Sovannary, Long Bunnath, Ham Samnom, Graeme Mardon, Qingwei Li, Anming Meng*, Hong Shi*, Bing Su. (co-correspondent author)& Su B *. A genetic mechanism for convergent skin lightening during recent human evolution. Mol Bio Evol. 2016 May 33(5):1177–1187.(IF:13.649)
4.Xiaoming Zhang, Shiyu Liao, Xuebin Qi, Jiewei Liu, Jatupol Kampuansai, Hui Zhang, Zhaohui Yang, Bun Serey, Tuot Sovannary, Long Bunnath, Hong Seang Aun, Ham Samnom, Daoroong Kangwanpong, Hong Shi*, Bing Su*. Y-chromosome diversity suggests southern origin and Paleolithic backwave migration of Austro-Asiatic speakers from eastern Asia to the Indian subcontinent. Sci. Rep. 2015 Oct, 5: 15486; doi: 10.1038/srep15486.
5.Xiaoming Zhang, Jatupol Kampuansai, Xuebin Qi, Shi Yan, Zhaohui Yang, Bun Serey, Tuot Sovannary, Long Bunnath, Hong Seang Aun, Ham Samnom, Wibhu Kutanan, Xin Luo, Shiyu Liao, Daoroong Kangwanpong, Li Jin, Hong Shi*, Bing Su**.An Updated Phylogeny of the Human Y-Chromosome Lineage O2a-M95 with Novel SNPs. PLoS ONE. 2014 June, 9(6):e101020.
6.Thirsa Kraaijenbrink, Kristiaan J van der Gaag, Sofia B Zuniga, Yali Xue, Denise R Carvalho-Silva, Chris Tyler-Smith, Mark A Jobling, Emma J Parkin, Bing Su, Hong Shi, Chun-Jie Xiao, Wen-Ru Tang, V K Kashyap, R Trivedi, T Sitalaximi, Jheelam Banerjee, Karma Tshering of Gaselô, Nirmal M Tuladhar, Jean-Robert M L Opgenort, George L van Driem, Guido Barbujani, Peter de Knijff. A Linguistically Informed Autosomal STR Survey of Human Populations Residing in the Greater Himalayan Region. PLoS ONE. 2014 March 9(3): e91534.
7.Li M, Luo XJ, Rietschel M, Lewis CM, Mattheisen M, Müller-Myhsok B, Jamain S, Leboyer M, Landén M, Thompson PM, Cichon S, Nöthen MM, Schulze TG, Sullivan PF, Bergen SE, Donohoe G, Morris DW, Hargreaves A, Gill M, Corvin A, Hultman C, Toga AW, Shi L, Lin Q, Shi H, Gan L, Meyer-Lindenberg A, Czamara D, Henry C, Etain B, Bis JC, Ikram MA, Fornage M, Debette S, Launer LJ, Seshadri S, Erk S, Walter H, Heinz A, Bellivier F, Stein JL, Medland SE, Arias Vasquez A, Hibar DP, Franke B, Martin NG, Wright MJ; MooDS Bipolar Consortium; Swedish Bipolar Study Group; Alzheimer’s Disease Neuroimaging Initiative; ENIGMA Consortium; CHARGE Consortium, Su B. Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility. Mol Psychiatry. 2014 Apr;19(4):452-61. (IF 15.147)
8.Xiaoming Zhang, Xuebin Qi, Zhaohui Yang, Bun Serey, Tuot Sovannary, Long Bunnath, Hong Seang Aun, Ham Samnom, Hui Zhang, Qiang Lin, Mannis van Oven, Hong Shi, Bing Su. Analysis of Mitochondrial Genome Diversity Identifies Novel and Ancient Maternal Lineages in Cambodian Aborigines. Nature Communications. 2013, 4:2599.(IF 10.742)
9.Xuebin Qi, Chaoying Cui, Yi Peng, Xiaoming Zhang, Zhaohui Yang, Hua Zhong, Hui Zhang, Kun Xiang, Xiangyu Cao, Yi Wang, Ouzhuluobu, Basang, Ciwangsangbu, Bianba, Gonggalanzi, Tianyi Wu, Hua Chen, Hong Shi, Bing Su. Genetic evidence of Paleolithic colonization and Neolithic expansion of modern humans on the Tibetan Plateau. Mol Biol Evol. 2013, 30(8):1761-1778. (IF 14.308)
10.Hong Shi, Xuebin Qi, Hua Zhong, Yi Peng, Xiaoming Zhang, Runlin Z Ma, Bing Su. Genetic evidence of an East Asian origin and Paleolithic northward migration of Y-chromosome haplogroup N. PLoS ONE. 2013 June,8(6):e66102.
11.Kun Xiang, Ouzhuluobu, Yi Peng, Zhaohui Yang, Xiaoming Zhang, Chaoying Cui, Hui Zhang, Ming Li, Yanfeng Zhang, Bianba, Gonggalanzi, Basang, Ciwangsangbu, Tianyi Wu, Hua Chen, Hong Shi, Xuebin Qi, Bing Su. Identification of a Tibetan-specific mutation in the hypoxic gene EGLN1 and its contribution to high-altitude adaptation. Mol Biol Evol. 2013, 30(8):1889-1898. (IF 14.308)
12.Ming Li, Xiong-Jian Luo, Xiao Xiao, Lei Shi, Xing-Yan Liu, Li-De Yin, Xiao-Yuan Ma, Shun-Ying Yang, Xing-Fu Pu, Jin Yu, Hong-Bo Diao, Hong Shi, Bing Su. Analysis of common genetic variants identifies RELN as a risk gene for schizophrenia in Chinese population. The World Journal of Biological Psychiatry, 2011 March, 14(2): 91-99.
13.Li R, Zhang XM, Campana MG, Huang JP, Chang ZH, Qi XB, Shi H, Su B, Zhang RF, Lan XY, Chen H and Lei CZ. Paternal origins of Chinese cattle. Animal Genetics. 2013, 44(4):446-449.
14.Qi XB, Shi H, Cui CY, Bianba, Ouzhuluobu, Wu TY and Su B. Peopleing of the Tibetan Plateau and genetic adaptation to high-altitude hypoxia in Tibetans. Science. 2012 December; 388(6113):1485(12-13).
15.Hong Shi. A commentary on “A multiplex SNP assay for the dissection of human Y-chromosome haplogroup O representing the major paternal lineage in East and Southeast Asia”. J Hum Genet. 2012, 57:5.
16.Yi Peng, Zhaohui Yang, Hui Zhang, Chaoying Cui, Xuebin Qi, Xiongjian Luo, Xiang Tao, Tianyi Wu, Ouzhuluobu, Basang, Ciwangsangbu, Danzengduojie, Hua Chen, Hong Shi, Bing Su. Genetic Variations in Tibetan Populations and High-Altitude Adaptation at the Himalayas. Mol Biol Evol. 2011, 28:1075-1081. (IF 11.221)
17.Hua Zhong, Hong Shi, Xue-Bin Qi, Zi-Yuan Duan, Ping-Ping Tan, Li Jin, Bing Su, Runlin Z Ma. Extended Y-chromosome investigation suggests post-Glacial migrations of modern humans into East Asia via the northern route. Mol Biol Evol. 2011, 28, 717-727.(IF 11.221)
18.Hong Shi and Su Bing. Molecular Adaptation of Modern Human Populations. Intern J Evol Bio. 2011, 484769, doi:10.4061/2011/484769.
19.Peng Y, Shi H, Qi XB, Xiao CJ, Zhong H, Ma Z RL, Su B. Genetic evidence of rice culture driven selection on the ADH1B Arg47His polymorphism in East Asian populations. BMC Evolu Biol. 2010, 10:15.
20.Hua Zhong, Hong Shi, Xue-Bin Qi, Chun-Jie Xiao, Li Jin, Runlin Z Ma, Bing Su. Global Distribution of Y-Chromosome Haplogroup C Reveals the Prehistoric Migration Routes of African Exodus and Early Settlement in East Asia. J Hum Genet. 2010, 55, 428-35.
21.Wei-Hua Shou, En-Fa Qiao, Chuan-Yu Wei, Yong-Li Dong, Si-Jie Tan, Hong Shi, Wen-Ru Tang & Chun-Jie Xiao. Y-chromosome distributions among populations in Northwest China identify significant contribution from Central Asian pastoralists and lesser influence of western Eurasians. J Hum Genet. 2010, 5:1–9.
22.Hong Shi, Si-jie Tan, Hua Zhong, Wenwei Hu, Arnold Levine, Chun-jie Xiao, Yi Peng, Xue-bin Qi, Wei-hua Shou, Run-lin Z Ma, Yi Li, Bing Su, Xin Lu. Winter Temperature and UV Are Tightly Linked to Genetic Changes in the p53 Tumor Suppressor Pathway in Eastern Asia. Am J Hum Genet. 2009 April; 84(4), 534–541. (Featured Article)(IF 12.16)
23.Hong Shi and Su Bing. Origin of Modern Humans in East Asia: clues from the Y chromosome. Front Biol China. 2009, 4(3): 241–247.
24.Hong Shi, Hua Zhong, Yi Peng, Yong-Li Dong, Xue-Bin Qi, Feng Zhang, Lu-Fang Liu, Si-Jie Tan, Runlin Z Ma, Chun-Jie Xiao, R Spencer Wells, Li Jin, Bing Su. Y chromosome evidence of earliest modern human settlement in East Asia and multiple origins of Tibetan and Japanese populations. BMC Biology. 2008 October, 6:45.
25.Thirsa Kraaijenbrink, Sofia Zuniga, Bing Su, Hong Shi, Chun-Jie Xiao, Wen-Ru Tang, Peter de Knijff. Allele frequency distribution of 21 forensic autosomal STRs in 7 populations from Yunnan, China. Forensic Science International: Genetics, 2008(3): e11–e12.
26.Hong Shi, Yong-liDong, BoWen, Chun-JieXiao, Peter A.Underhill, Pei-dong Shen, Ranajit Chakraborty,LiJin, BingSu. Y-chromosome evidence of southern origin of the East Asian-specific haplogroup O3-M122. Am J Hum Genet. 2005 Sep; 77(3):408-19. (IF 12.65)
27.Hong Shi, Yongli Dong, Weixiang Li, Jie Yang, Kaiyuan Li, Ruiguang Zan, Chunjie Xiao. The geographic polymorphisms of Y chromosome at YAP locus among 25 ethnic groups in Yunnan, China. Sci China C Life Sci. 2003 April; 46 (2):135-140.
28.Xiao-hua Chen, Hong Shi, Xiao-Lin Liu, Bing Su. The testis-specific apoptosis related gene TTL.6 underwent adaptive evolution in the lineage leading to humans. Gene, 2006 Mar 29; 370C:58-63.
29.Yin-Qiu Wang 1, Ya-Ping Qian, Su Yang, Hong Shi, Cheng-Hong Liao, Hong-Kun Zheng, Jun Wang, Alice A Lin, L Luca Cavalli-Sforza, Peter A Underhill, Ranajit Chakraborty, Li Jin, Bing Su. Accelerated evolution of the pituitary adenylate cyclase-activating polypeptide precursor gene during human origin. Genetics. 2005 Jun; 170 (2):801-6.
30.Wen Bo 1, Shi Hong, Ren Ling, Xi Huifeng, Li Kaiyuan, Zhang Wenyi, Su Bing, Si Shiheng, Jin Li, Xiao Chunjie. The origin of Mosuo people as revealed by mtDNA and Y chromosome variation. Sci China C Life Sci. 2004 Feb; 47 (1):1-10.
31.Bo Wen 1, Xuanhua Xie, Song Gao, Hui Li, Hong Shi, Xiufeng Song, Tingzhi Qian, Chunjie Xiao, Jianzhong Jin, Bing Su, Daru Lu, Ranajit Chakraborty, Li Jin. Analyses of genetic structure of Tibeto-Burman populations reveals sex-biased admixture in southern Tibeto-Burmans. Am J Hum Genet. 2004 May; 74 (5):856-65. (IF 12.34)
32.Xiaoxia Yang,Zhili Yang,Hong Shi,Yongli Dong,Jie Yang,Weimin Zeng,Lu Gao &Chunjie Xiao. Y-STR polymorphisms among five Chinese minorities, Mosuo, Mongolian, Naxi, Pumi and Tibetan, in Yunnan Province, PR China. Ann Hum Biol. 2004 Jan-Feb; 31 (1):103-11.
33.Qi XueBin, Yang Su, Zheng HongKun, Wang YinQiu, Liao ChengHong, Liu Ying, Chen XiaoHua, Shi Hong, Yu XiaoJing, Alice A. Lin, Luca L. Cavalli-Sforza, Wang Jun & Su Bing (2007) Detecting positive Darwinian selection in brain-expressed genes during human evolution. Chinese Science Bulletin 52:324-335.
© Copyright 昆明理工大学灵长类转化医学研究院、云南中科灵长类生物医学重点实验室 滇ICP备19003551号