• 王宏(Wang Hong)

    博士,教授

    实验动物中心负责人

    DVM, Professor.

    Director of Laboratory Animal Center

    一、受教育及工作经历

    • 09/1996-07/2000,湖北农学院,动物科学系,学士
    • 09/2001-06/2004,福建农林大学,动物科学学院,硕士
    • 01/2016-12/2019,中国农业大学,动物医学院,博士
    • 05/2006-07/2007,美国俄勒冈国家灵长类研究中心,访问学者
    • 08/2000-08/2001,湖北武汉东西湖区畜牧兽医研究所,兽医
    • 07/2004-12/2014,中国科学院昆明动物研究所,助理研究员
    • 12/2014-12/2016,昆明亚灵生物科技有限公司,执业兽医师、高级兽医师、副研究员
    • 12/2014至今,云南中科灵长类生物医学重点实验室,高级兽医师、副研究员、研究员
    • 09/2020至今,昆明理工大学灵长类转化医学研究院,教授

     

    EDUCATION

     

    • 09/1996-07/2000 Bachelor Degree of Veterinary Medicine, Animal Husbandry and Veterinary Medicine College of Hubei Agriculture University, Hubei, China.
    • 09/2001-06/2004 Master Degree of Animal Genetics and Reproduction, Animal Science College of Fujian Agricultural and Forestry University, Fujian, China.
    • 01/2016-12/2019 Doctor Degree of Veterinary Medicine, Animal Medicine College of China Agriculture University, Beijing, China.
    • 05/2006-07/2007 Visiting scholar, Animal Resource Division of Oregon National Primate Research Center, Oregon Health & Science University, Oregon, USA.

     

    WORK EXPERIENCE

     

    • 08/2000-08/2001  Wuhan DONGXI-Lake Institute of Animal Science and Veterinary.
    • 07/2004-12/2014  Kunming Primate Research Center, and Kunming Institute of Zoology, Chinese Academy of Sciences.
    • 12/2014-12/2016  Kunming Biomed International.
    • 12/2014 to the present  Yunnan Key Laboratory of Primate Biomedicine Research.
    • 09/2020 to the present  Institute of Primate Translational Medicine, Kunming University of Science and Technology.

    二、主要研究方向

    • 实验动物标准化研究与应用
    • 灵长类动物疾病诊断与治疗
    • 人类疾病灵长类动物模型建立及致病机理研究

     

    • Study and application of laboratory animal standardization
    • Diagnosis and treatment of nonhuman primate diseases
    • Study on establishment and pathogenic mechanism of primate model of human disease

    三、承担或参与科研项目

    1. 国家自然科学基金地区基金项目:益生菌对猕猴酒精性肝损伤的保护作用及机制研究,2020-2023,主持。
    2. 人力资源和社会保障部择优资助项目:猕猴酒精性脂肪肝模型的创制,2014-2017,主持。
    3. 昆明市科技局重点项目:无特定病原体实验猕猴培育关键技术研究与应用,2014-2016,主持。
    4. 云南省科技厅重点项目:猕猴膨化饲料生产关键技术研究与示范,2014-2017,主持。
    5. 云南省科技厅:技术创新人才培养计划项目,2014-2019,主持。
    6. 国家科技支撑计划项目子课题:灵长类实验动物标准化研究与数据管理系统建设,2007-2011,主持。
    7. 科技部重大专项:评价抗HCV化学药物疗效和安全性的动物模型,2009-2012,参与。
    8. 云南省国际合作项目:标准化灵长类实验动物国际认证建设,2006-2009,参与。
    9. 科技部973课题:肝炎等重大人类疾病的灵长类模型研制,2012-2016,参与。
    10. 科技部863课题:神经退行性疾病灵长类动物模型制备关键技术及利用,2012-2015,参与。
    11. 国家自然科学基金重点项目:帕金森氏症转基因灵长类动物模型的构建与致病机理研究,2014-2017,参与。

    四、奖励情况

    1. 昆明市第十批中青年学术和技术后备人选,2012年。
    2. 昆明市科技进步一等奖(获奖人:王宏、季维智、严晔、牛昱宇、司维、纪少珲、马原野、朱建国、陈永昌),2013年。
    3. 云南省科技进步三等奖(获奖人:王宏、季维智、严晔、牛昱宇、司维、纪少珲、马原野),2015年。
    4. 昆明市第十四批中青年学术带头人,2016年。
    5. 昆明市科技进步三等奖(获奖人:王宏、季维智、陈智岗、牛昱宇、司维、张龙、韦秋奖),2017年。
    6. 云南省自然科学一等奖(获奖人:季维智、牛昱宇、陈永昌、司维、王宏、康宇、司晨洋),2018年。
    7. 云南省政府特殊津贴获得者,2018年。
    8. 云南省科技进步三等奖(获奖人:王宏、陈智岗、李鹤龄、牛昱宇、司维、张龙、韦秋奖),2019年。
    9. 云南省技术创新人才,2019年。
    10. 昆明市呈贡区精英人才称号,2019年。

    五、授权和申请专利

    1. 王宏、牛昱宇、司维、纪少珲、赵博、季维智,猕猴肝损伤动物模型构建方法,授权号:ZL201010200583.4
    2. 王宏、季维智、严晔,通用型灵长类实验动物的标准化饲养装置,授权号:ZL201020235892.0
    3. 牛昱宇、王宏、司维、郭祥玉、司晨洋、王芳、张琼书、施桂英,树鼩非酒精单纯性脂肪肝动物模型的构建方法,授权号:ZL201210106203.X
    4. 王宏、牛昱宇,一种实验用树鼩固定装置,授权号:ZL201120317195.4
    5. 王宏、季维智、牛昱宇、司维,一种实验用灵长类动物多功能转移笼,授权号:ZL20152061781.3
    6. 王宏、韦秋奖,一种无特定病原体级实验动物出口检疫期的养殖方法,申请号:201510518168.9
    7. 司维、王宏、严亚萍、王峻峰、常绍辉、段艳超、牛昱宇、季维智,黄曲霉素诱导猕猴肝纤维化模型的方法,申请号:201610692028.5

    六、著作

    《猕猴繁殖生物学》,科学出版社,参编,2013年。

    七、代表性论文 PUBLICATIONS

    1. Tao Tan, Jun Wu, Chenyang Si, Shaoxing Dai, Youyue Zhang, Nianqin Sun, E Zhang, Honglian Shao, Wei Si, Pengpeng Yang, Hong Wang, Zhenzhen Chen, Ran Zhu, Yu Kang, Reyna Hernandez-Benitez, Llanos Martinez Martinez, Estrella Nuñez Delicado, W Travis Berggren, May Schwarz, Zongyong Ai, Tianqing Li,,Chimeric contribution of human extended pluripotent stem cells to monkey embryos ex vivo. Cell, 2021,184, 2020-2032.
    2. Ting Zhang, Yu Kang, Li Li, Yin Zhou, Xinglong Chen, Yan Zhuo, Zifan Li, Hong Wang, Yuyu Niu, Weizhi Ji, Shangang Li, Yongchang Chen. Interspecies embryo transfer between rhesus and cynomolgus monkeys. Journal of Genetics and Genomics, 2020, DOI: 10.1016/j.jgg.2020.04.002.
    3. Yuyu Niu #, Nianqin Sun #, Chang Li #, Ying Lei #, Zhihao Huang, Jun Wu, Chenyang Si, Xi Dai, Chuanyu Liu, Jingkuan Wei, Longqi Liu, Su Feng, Yu Kang, Wei Si, Hong Wang, E Zhang, Lu Zhao, Ziwei Li, Xi Luo, Guizhong Cui, Guangdun Peng, Juan Carlos Izpisúa Belmonte, Weizhi Ji, Tao Tan. Dissecting primate early post-implantation development using long-term in vitro embryo culture. Science. 366(6467).
    4. Lei Shi, Xin Luo, Jin Jiang, Yongchang Chen, Cirong Liu, Ting Hu, Min Li, Qiang Lin, Yanjiao Li, Jun Huang, Hong Wang, Yuyu Niu, Yundi Shi, Martin Styner, Jianhong Wang, Yi Lu, Xuejin Sun, Hualin Yu, Weizhi Ji. Transgenic rhesus monkeys carrying the human MCPH1 gene copies show human-like neoteny of brain development. National Science Review,2019, DOI: 10.1093/nsr/nwz043/5420749.
    5. Hong Wang, Yaping Yan, Xiaoyan Yi, Yanchao Duan, Junfeng Wang, Shanshan Li, Lilin Luo, Tianzhuang Huang, Briauna Inglis, Xi Li, Weizhi Ji, Tao Tan, Wei Si. Histopathological features and composition of gut microbiota in Rhesus Monkey of alcoholic liver disease. Frontiers in Microbiology,2019, DOI: 10.3389/fmicb.2019.00165.
    6. Xufeng Fu #, Bin Jiang #, Bingrong Zheng #, Yaping Yan, Junfeng Wang, Yanchao Duan, Shanshan Li, Li Yan, Hong Wang, Bingbing Chen, Xiongbo Sang, Weizhi Ji, Ren-He Xu, Wei Si. Heterogenic transplantation of bone marrow-derived rhesus macaque mesenchymal stem cells ameliorates liver fibrosis induced by carbon tetrachloride in mouse. Peer J, 2018, 6:e4336.
    7. Xufeng Fu, Yaping Yan, Shanshan Li, Junfeng Wang, Bin Jiang, Hong Wang, Yanchao Duan, Tao Tan, Fei Gao, Desheng Gong, Yuyu Niu, Weizhi Ji, Bingrong Zheng, Wei Si. Vitrification of Rhesus Macaque Mesenchymal Stem Cells and the Effects on Global Gene Expression. Stem Cells Int. 2017:3893691.
    8. Bingbing Chen, Shanshan Li, Yaping Yan, Yanchao Duan, Shaohui Chang, Hong Wang, Weizhi Ji, Xin Wu, Wei Si. Cryopreservation of cynomolgus macaque (Macaca fascicularis) sperm with glycerol and ethylene glycol, and its effect on sperm-specific ion channels d CatSper and Hv1. Theriogenology, 2017,104: 37-42.
    9. Wang Hong , Chen Zhigang,  Chen Lixian,  Zong Faliang,  Li Heling . Survey and analysis of common diseases of laboratory monkeys,taking Kunming area as an example. Animal Husbandry and Feed Science, 2017,9(5):289-292.
    10. Hong Wang, De-Cheng WANG, Li-Xian CHEN and Zhi-Gang CHEN. A case of oral cavity squamous cell carcinoma in an adult female rhesus monkey(macaca mulatta). International Journal of Advances In Case Reports, 2017;4(1):5-8.
    11. Yan Yaping, Ao Lei, Wang Hong, Duan Yanchao, Chang Shaohui, Chen Bingbing, Zhi Dalong, Li Sujuan, Niu Yuyu, Ji Weizhi, Si Wei. Cryopreservation of Cynomolgus Macaque (Macaca fascicularis) sperm by using a commercial Egg-Yolk–Free freezing medium. Journal of the American Association for Laboratory Animal Science. 2016, 55:744-748.
    12. Zongyong Ai, Zheng Xiang, Yuemin Li, Guoku Liu, Hong Wang, Yun Zheng, Xiaoyan Qiu, Shumei Zhao, Xiaoqing Zhu, Yanhua Li, Weizhi Ji, Tianqing Li Conversion of monkey fibroblasts to transplantable telencephalic neuroepithelial stem cells. Biomaterials, 2016,77:53-65.
    13. Hong Wang, Tao Tan, Junfeng Wang, Yuyu Niu, Yaping Yan, Xiangyu Guo, Yu Kang, Yanchao Duan, Shaohui Chang, Jianpeng Liao, Chenyang Si, Weizhi Ji, Wei Si. Rhesus monkey model of liver disease reflecting clinical disease progression and hepatic gene expression analysis. Scientific Reports, 2015,5:15019. DOI: 10.1038/srep15019.
    14. Yuyu Niu, Xiangyu Guo, Yongchang Chen, Chuan-En Wang, Jinquan Gao, Weili Yang, Yu Kang, Wei Si, Hong Wang, Shang-Hsun Yang, Shihua Li, Weizhi Ji, Xiao-Jiang Li. Early Parkinson’s disease symptoms in α-synuclein transgenic monkeys. Human Molecular Genetics, 2015, 24(8): 2308–2317.
    15. Hong  Wang; Wei, Si; Yin, Zhou; Lixian, Chen. Artificial nursing procedure establishment for infant rhesus monkey. Animal Husbandry and Feed Science,2015,7(6):381-382.
    16. Yongchang Chen, Yinghui Zheng, Yu Kang, Weili Yang, Yuyu Niu, Xiangyu Guo, Zhuchi Tu, Chenyang Si, Hong Wang, Ruxiao Xing, Xiuqiong Pu, Shang-Hsun Yang, Shihua Li, Weizhi Ji, Xiao-Jiang Li. Functional disruption of the dystrophin gene in Rhesus Monkey Using CRISPR/Cas9. Human Molecular Genetics, 2015,24(13):3764-3774.
    17. Yu Kang, Bo Zheng, Bin Shen, Yongchang Chen, Lei Wang, Jianying Wang, Yuyu Niu, Yiqiang Cui, Jiankui Zhou, Hong Wang, Xuejiang Guo, Bian Hu, Qi Zhou, Jiahao Sha, Weizhi Ji, Xingxu Huang. CRISPR/Cas9-mediated Dax1 knockout in the monkey recapitulates human AHC-HH. Human Molecular Genetics, 2015, 24(25): 7255–7264.
    18. Wang H, Chen L. A rare case of unusual giant gallbladder in a 24 years old female rhesus monkey(Macaca mulatta). International Journal of Advances In Case Reports, 2015,2(19):1162-1163.
    19. Wang H, Yan Y, Li R, Chen Z, Kang Y, Si C, Ji W, Si W, Niu Y. A timed liver tissue collection method for hepatology evaluation in tree shrew. Journal of Science,2015(7):500-504.
    20. Hailiang Liu #, Yongchang Chen #, Yuyu Niu #, Kunshan Zhang #, Yu Kang, Weihong Ge, Xiaojing Liu, Enfeng Zhao, Chencheng Wang, Shaoyun Lin, Bo Jing, Chenyang Si, Quan Lin, Xiaoying Chen, Haijun Lin, Xiuqiong Pu, Yingying Wang, Binlian Qin, Fang Wang, Hong Wang, Wei Si, Jing Zhou, Tao Tan, Tianqing Li, Shaohui Ji, Zhigang Xue, Yuping Luo, Liming Cheng, Qi Zhou, Siguang Li, Yi Eve Sun, Weizhi Ji. TALEN-Mediated Gene Mutagenesis in Rhesus and Cynomolgus Monkeys. Cell Stem Cell,2014(14):323-328.
    21. Yuyu Niu, Bin Shen, Yiqiang Cui, Yongchang Chen, Jianying Wang, Lei Wang, Yu Kang, Xiaoyang Zhao, Wei Si, Wei Li, Andy Peng Xiang, Jiankui Zhou, Xuejiang Guo, Ye Bi, Chenyang Si, Bian Hu, Guoying Dong, Hong Wang, Zuomin Zhou, Tianqing Li, Tao Tan, Xiuqiong Pu, Fang Wang, Shaohui Ji, Qi Zhou, Xingxu Huang, Weizhi Ji, Jiahao Sha. Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos. Cell,2014(156):836-843.
    22. Rui Liu, Zheng Zhang, Huan Liu, Panpan Hou, Jun Lang, Sheng Wang, Hongli Yan, Pengcheng Li, Zhigang Huang, Hongbing Wu, Mingqiang Rong, Jian Huang, Hong Wang, Longbao Lv, Mingfeng Qiu, Jiuping Ding, Ren Lai. Human -Defensin 2 Is a Novel Opener of Ca2+-Activated Potassium Channels and Induces Vasodilation and Hypotension in Monkeys. Hypertension, 2013, 62(2): 415-425.
    23. Wang H, Niu Y, Si W, Li Y, Yan Y. Reference data of clinical chemistry, haematology and blood coagulation parameters in juvenile cynomolgus monkeys (Macaca fascicularis). Veterinarni Medicina, 2012(5):233-238.
    24. Yongchang Chen, Yuyu Niu, Shihua Yang, Xiechao He, Shaohui Ji, Wei Si, Xianghui Tang, Yunhua Xie, Hong Wang, Yongqing Lu, Qi Zhou, Weizhi Ji. The available time window for embryo transfer in rhesus monkey (Macaca Mulatta). American Journal of Primatology, 2012(74):165-173.
    25.  Wang Hong ;  Si Wei ;  Niu YuYu ;  Chen LiXian ;  Yan Ye. Unusual vesical calculus in rhesus monkey (macaca mulatta). Journal of Animal and Veterinary Advances, 2012(11):1790-1792.
    26. Yuyu Niu, Yang Yu, Agnieszka Bernat, Shihua Yang, Xiechao He, Xiangyu Guo, Dongliang Chen, Yongchang Chen, Shaohui Ji, Wei Si, Yongqin Lv, Tao Tan, Qiang Wei, Hong Wang, Lei Shi, Jean Guan, Xuemei Zhu, Marielle Afanassieff, Pierre Savatier, Kang Zhang, Qi Zhou, Weizhi Ji Transgenic rhesus monkeys produced by gene transfer into early-cleavage–stage embryos using a simian immunodeficiency virus-based vector. Proc Natl Acad Sci USA(PNAS), 2010(107):17663-17667.
    27. 王宏,陈永昌,司维,陈兴龙,周引. 猕猴剖宫产及术后护理.黑龙江畜牧兽医,2015,9:168-169.
    28. 王宏,司维,周引,陈利仙. 恒河猴婴猴人工护理程序的建立.安徽农业科学,2015,43(17):159-161.
    29. 王宏,韦秋奖. 食蟹猴SPF种群建立过程中病毒抗体动态监测.中国实验动物学报,2015,23(6):573-577.
    30. 韦秋奖,王宏. 猕猴结肠小袋纤毛虫和鞭毛虫感染调查及治疗效果研究.黑龙江畜牧兽医,2015,24:159-161.
    31. 王宏,韦秋奖,江海天,陈智岗. 实验猕猴细菌性痢疾的治疗.中国兽医杂志,2016,52(6):97-99.
    32. 王宏,陈智岗,宗发梁,李鹤龄. 食蟹猴直肠脱的手术治疗.中国畜牧兽医文摘,2016,32(10):206.
    33. 王宏,陈智岗,陈利仙,宗发梁,李鹤龄. 昆明地区试验猴常见疾病的调查分析. 中国畜牧兽医,2017,44(5):1557-1564.
    34. 王宏,付学魏,陈智岗,宗发梁,李鹤龄,韦秋奖. 昆明地区恒河猴、食蟹猴种群繁殖规律和繁殖性能研究. 中国比较医学杂志,2017,27(7):34-39.
    35. 王宏,张龙,李鹤龄,陈智岗,宗发梁. 膨化饲料对生长期猕猴增重和营养消化率的影响, 黑龙江畜牧兽医,2017,18:139-141.
    36. 付旭锋,陈冰冰,严亚萍,王宏,王峻峰,郑冰蓉,司维. 动物模型在间充质干细胞治疗慢性肝病临床前研究的应用,中国实验动物学报,2017,25:102-106.
    37. 王宏,韦秋奖,陈智岗,周霁. 猕猴档案管理系统的开发与应用,畜牧兽医科学,2017,12:17-19.
    38. 王宏,陈智岗,张龙,宗发梁. 猕猴大叶性肺炎的诊断与防治.黑龙江畜牧兽医,2018,8:181-182.
    39. 王宏. 标准化猕猴养殖基地的建设与管理. 黑龙江畜牧兽医,2018,14:205-208.
    40. 李鹤龄,王宏,陈智岗,宗发梁. 规模化猕猴养殖场的消毒管理. 上海畜牧兽医通讯,2018,4:52-53.
    41. 王宏,张龙,李鹤龄,陈智岗,宗发梁. 膨化加工方法对猕猴饲料营养成分的影响.中国饲料,2018,15:32-35
    42. 李鹤龄,王宏,陈智岗,宗发梁. 恒河猴和食蟹猴毛发氨基酸和微量元素测定分析. 上海畜牧兽医通讯,2018,5:8-10.
    43. 王宏,赵德明,季维智,李鹤龄. 猕猴小袋纤毛虫形态学观察及分子生物学鉴定.中国兽医学报,2019,39(1):74-80.
    44. 李鹤龄,王宏,张龙,陈智岗,宗发梁. 恒河猴脱毛症及毛发营养学分析. 上海畜牧兽医通讯,2019,1:44-46.
    45. 周智刚,段志刚,王宏,龚南南,刘杰,陈兴龙,卓艳,周引,张婷,陈永昌. 非人灵长类个性化麻醉方案的探讨,中国实验动物学报,2019,27(4):473-478.
    46. 王宏. 实验猕猴在生物医学研究中的福利管理. 生命科学,2020,32(7):711-716.
    47. 王宏,李鹤龄,陈智岗,宗发梁. 猕猴肠道寄生虫研究进展,安徽农业科学,2021.
    48. 李鹤龄,王宏,陈智岗,宗发梁. 猕猴源毛滴虫的鉴定,中国兽医杂志,2021.
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