• 王晓群(Xiaoqun Wang)

    中科院生物物理研究所,脑与认知科学国家重点实验室副主任,二级研究员,长聘岗位

    中国科学院脑科学与智能技术卓越中心成员

    中国科学院大学岗位教授(A类),神经科学与心理学教研室主任

    一、工作经历

    • 2000/9 - 2004/05,中科院遗传与发育所,遗传与发育,博士;
    • 2004/05 – 2006/12,加州大学旧金山分校,遗传发育与神经科学专业,访问学者;
    • 2007/01 – 2009/10,纪念斯隆-凯特癌症研究中心,发育生物学系,博士后;
    • 2009/01 – 2012/10,加州大学旧金山分校,干细胞与再生医学研究所,助理教授(研究系列);
    • 2012/10 - 至今,中科院,生物物理研究所,研究员/教授。

    二、承担科研项目情况

    • 国家重大科学研究计划,2014CB964600、“成体神经干细胞的命运决定机制与功能研究” 首席科学家(973)(2014-2018)
    • 国家重点研发计划, 2019YFA0110100 “区域特异性神经干细胞的获取以及功能特性和应用的研究 首席科学家 (2019-2023)

    三、获奖情况

    • 谈家桢生命科学创新奖(2019)
    • 干细胞研究创新奖(2018)

    四、代表性论文

    1. Shi Y, Wang M, Sun L, Wu Q*, Wang X* Vascularized human cortical organoids (vOrganoid) model cortical development in vivo" Plos Biology. 2020; accepted. *Corresponding Author.
    2. Lu Y, Yi W, Shiau F, Lu S, Wu Q, Xue T, et al Wang X* Single-cell analysis of human retina identifies evolutionarily conserved and species specific mechanisms controlling development. Developmental Cell. 2020; accepted. *Corresponding Author.
    3. Yin. C, Zhou X, Wang W, Yao Y, Wu Q* and Wang X* Abundant self-amplifying intermediate progenitors in the subventricular zone of the Chinese tree shrew neocortex 2020 Cerebral Cortex Accepted. Corresponding Author.
    4. Xie H, Zhang W, Zhang M, Akhtar T, Li W, Sun X, Zuo Z, Wei W, Fang X, Yao Z, Dong K, Zhong S, Liu Q, Shen Y, Wu Q, Wang X, Zhao H, Bao J, Qu K, Tian Xue Chromatin accessibility analysis reveals regulatory dynamics of developing human retina and hiPSC-derived retinal organoids. Sci Adv. 2020;6(6):eaay5247. Published 2020 Feb 7.
    5. Zhong S, Ding W, Sun L, Lu Y, Dong H, Fan X, Liu Z, Chen R, Zhang S, Ma Q, Tang F, Wu Q*, Wang X*. Decoding the development of human hippocampus. Nature. 2020; 577(7791): 531–536. *Corresponding Author.
    6. Yu H, Zhao T, Liu S, Wu Q, Johnson O, Wu Z, Zhuang Z, Shi Y, Peng L, He R, Yang Y, Sun J, Wang X, Xu H, Zeng Z, Zou P, Lei X, Luo W, Li Y. MRGPRX4 is a bile acid receptor for human cholestatic itch. Elife. 2019 Sep 10;8. pii: e48431. doi: 10.7554/eLife.48431.
    7. Ding W. Y., Wu Q., Sun L, Pan N., and Wang X*. Cenpj regulates cilia disassembly and neurogenesis in the developing mouse cortex. J of Neuroscience. J Neurosci. 2019 Jan 9. Corresponding Author.
    8. Yang Y, Chen R, Wu X, Zhao Y, Fan Y, Xiao Z, Han J, Sun L, Wang X, Dai J. Rapid and Efficient Conversion of Human Fibroblasts into Functional Neurons by Small Molecules. Stem Cell Reports. 2019 Nov 12;13(5):862-876. doi: 10.1016/j.stemcr.2019.09.007. Epub 2019 Oct 17.
    9. Ji C, Zhao H, Li D, Sun H, Hao J, Chen R, Wang X, Zhang H, Zhao YG. Role of Wdr45b in maintaining neural autophagy and cognitive function. Autophagy. 2019 Jun 25:1-11.
    10. Tong DL, Chen RG, Lu YL, Li WK, Zhang YF, Lin JK, He LJ, Dang T, Shan SF, Xu XH, Zhang Y, Zhang C, Du YS, Zhou WH, Wang X*, Qiu Z*. The critical role of ASD-related gene CNTNAP3 in regulating synaptic development and social behavior in mice. Neurobiol Dis. 2019 May *Corresponding Author.
    11. Zhong S., Zhang S., Fan X., Wu Q., Yan L., Zhang H., Li L., Sun. L, Pan N., Xu X., Tang F., Zhang J., Qiao J., Wang X.  Single-cell RNA-Seq analysis reveals a developmental atlas of the human prefrontal cortex. Nature. 2018 Mar. 14; publish online. *Corresponding Author.
    12. Pan N, Fang A, Shen C, Sun L, Wu Q and Wang X*. Early Excitatory Activity-dependent Maturation of Somatostatin Interneurons in Cortical Layer 2/3 of Mice Cerebral Cortex. 2018 Dec 7. Corresponding Author.
    13. Sun L*,Chen R, Bai Y, Li J, Wu Q*, Shen Q,* Wang X*.  Morphological and Physiological Characteristics of Ebf2-EGFP-Expressing Cajal-Retzius Cells in Developing Mouse Neocortex.Cerebral Cortex. 2018 Oct 11.Corresponding Author.
    14. Fan X, Dong J, Zhong S, Wei Y, Wu Q, Yan L, Yong J, Sun L, Wang X, Zhao Y, Wang W, Yan J, Wang X*, Qiao J*, Tang F*. Spatial transcriptomic survey of human embryonic cerebral cortex by single-cell RNA-seq analysis. Cell Res. 2018 Jul; 28(7):730-745. *Corresponding Author.
    15. Shi Y, Li S, Wu Q, Sun L, Zhang J, Pan N, Wang Q, Bi Y, An J, Lu X, Gao GF, Wang X. Vertical Transmission of the Zika Virus Causes Neurological Disorders in Mouse Offspring. Sci Rep. 2018 Feb 23;8(1):3541.
    16. Liu J, Liu W, Yang L, Wu Q, Zhang H, Fang A, Li L, Xu X, Sun L, Zhang J, Tang F, Wang X. The Primate-Specific Gene TMEM14B Marks Outer Radial Glia Cells and Promotes Cortical Expansion and Folding, Cell Stem Cell. 2017 https://doi.org/10.1016/j.stem.2017.08.013
    17. Li R, Sun L, Fang A, Li P, Wu Q, Wang X. Recapitulating cortical development with organoid culture in vitro and modeling abnormal spindle-like (ASPM related primary) microcephaly disease. Protein Cell. 2017. 2017 Nov;8(11):823-833. doi: 
    18. Wu Q, Li R, Sun L, Liu J, Fang A, Liu W, Li L, Yang M, Wang X. Neocortical Expansion and Neurodevelopmental Disease. Prog. Biochem. Biophys. 2016, 43(4): 389~397.
    19. Ju XC, Hou QQ, Sheng AS, Wu KY, Zhou Y, Jin Y, Wen T, Yang Z, Wang X, Luo ZG. The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice. Elife. 2016 Aug 9;5. pii: e18197.
    20. Yuan Q, Deng KY, Sun L, Chi S, Yang Z, Wang J, Xin HB, Wang X*, Ji G*. Calstabin 2: An important regulator for learning and memory in mice.Sci Rep. 2016 Feb 18;6:21087. *Co-corresponding authors
    21. Wang Y, Wu Q, Yang P, Wang C, Liu J, Ding W, Liu W, Bai Y, Yang Y, Wang H, Gao S, Wang X. LSD1 corepressor RCOR2 orchestrates neurogenesis in the developing mouse brain. Nature Communications. 2016 Jan 22;7:10481.
    22. Kou Z, Wu Q, Kou X, Yin C, Wang H, Zuo Z, Zhuo Y, Chen A, Gao S, Wang X. CRISPR/Cas9-mediated genome engineering of the ferret. Cell Research. 2015 Dec;25(12):1372-5
    23. Zhao YG, Sun L, Miao G, Ji C, Zhao H, Sun H, Miao L, Yoshii SR, Mizushima N, Wang X, Zhang H. The autophagy gene Wdr45/Wipi4 regulates learning and memory function and axonal homeostasis. Autophagy. 2015;11(6):881-90.
    24. Caitlyn C. Gertz, Jan Liu, Bridget Lamonica, Xiaoqun Wang &Arnold. R. Kriegstein. Diverse Behaviors of Outer Radial Glia in Developing Ferret and Human Cortex. The Journal of Neuroscience, 2014. Feb. 12;34 (7):2559-70
    25. Qian Wu, Jing Liu, Ai Fang, Rui Li, Ye Bai, Arnold Kriegstein and Xiaoqun Wang. The Dynamic of neuronal migration. Adv. Exp. Med. Biol. 2014; 800:25-36.
    26. Rui Li, Ye Bai, Tingting Liu, Xiaoqun Wang and Qian Wu. Induced pluripotency and direct reprogramming: a new window for treatment of neurodegenerative diseases. Protein Cell. 2013 Jun;4(6):415-24.
    27. Qian Wu and Xiaoqun Wang. Neuronal stem cells in the central nervous system and in human diseases. Protein Cell. 2012 Apr;3(4):262-70
    28. Xiaoqun Wang and Arnold. R. Kriegstein.  OSVZ Radial Glial Cells, Book Chapter, Neuroglia. 3rd Edition. Oxford University Press. 2012. ISBN13: 978-0-19-979459-1.
    29. Bridget Lamonic, Jan Liu, Xiaoqun Wang & Arnold. R. Kriegstein.  An updated perspective on human neurodevelopmental disease. Current Opinion in Neurobiology. 2012 Oct;22(5):747-53.
    30. Xiaoqun Wang, Jan Liu& Arnold. R. Kriegstein.  Orienting fate: spatial regulation of neurogenic divisions. Neuron. 2011 Oct. 20; 72(2): 191-3。
    31. Xiaoqun Wang*, Jin-wu Tsai, Bridget Lamonica & Arnold. R. Kriegstein*. A new subtype of cortical progenitor cell in the mouse embryonic neocortex. Nat Neurosci, 14, 555–561 (2011) (Cover; featured in News and Views) * Co-corresponding author.
    32. Xiaoqun Wang, Jin-wu Tsai, Janice H. Imai, Wei-Nan Lian, Richard B. Vallee & Song-Hai Shi. et al, Asymmetric segregation of mother and daughter centrosome in mammal neocortex. Nature. 2009 Oct 15; 461: 947-55. (Cover; Featured in News and Views)
    33. Yong-chun Yu, Ronald s Buiter, Xiaoqun Wang and Song-hai Shi. Specific synapses develop preferentially among sister excitatory neurons in the neocortex. Nature 2009 Mar 26; 458: 501-4.
    所有文章
    ×