一、教育及工作经历 Education
二、工作经历 Work Experience
1. Nov. 2022-Present, Professor, StateKey Laboratory of Non-Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology.
2. Jan. 2022-Nov. 2022, AssociateProfessor, State Key Laboratory of Non-Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology.
3. Jan. 2014-Jan. 2022, AssociateProfessor, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences.
4. Jan. 2007-Dec. 2013, AssistantProfessor, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences.
5. Oct. 2004-Dec. 2006, PostdoctoralFellow, Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences.
6. June 2004-Sept. 2004, VisitingScientist, International Livestock Research Institute, Nairobi, Kenya.
三、主要研究方向 Main Research Directions
1. 遗传分析与测序平台
Genetic Analysisand Sequencing Platform
2. 灵长类表型组与疾病的遗传机制
GeneticMechanism underlying Primate Phenome and Disease
3. 人和动物对高原低氧环境的习服与适应机制
Molecular Mechanismunderlying Acclimatization and Adaptation to High Altitude Hypoxia
四、科研领域描述 Description of Scientific Research
1、遗传分析与测序平台
建立包括单细胞测序在内的各种多组学测序文库构建技术、多组学数据质控与分析流程、多组学功能元件发掘等组学分析方法,为灵长类转化医学研究院提供高质量的组学建库与测序技术支撑。
Establishing GeneticAnalyses and Sequencing Platform support for School of Primate Translational Medicine, including multi-omics library construction, quality control and analytical pipeline for sequencing data, data mining for functional genomic elements in
primates etc..
2、灵长类表型组与疾病的遗传机制
利用多组学手段解析灵长类表型组与疾病的调控机制
Decipheringgenetic mechanism underlying the phenome and disease in primates by using
multi-omics technologies.
3、人和动物对高原低氧环境的习服与适应机制
利用多组学技术解析人和动物对高原低氧环境的习服与适应机制
Deciphering genomicmechanism underlying the acclimatization and adaptation to high altitude hypoxia in human and animals.
五、承担科研项目情况 Research Projects
1. 解析高原衰退症的流行病学分布模式及其关键影响因素与调控机制,国家自然科学区域创新发展联合基金重点支持项目,U22A20340,2023.01-2026.12,89.25/255万元,在研,参与。
Deciphering the epidemiological patterns of high altitude deterioration and its impact factors and regulative mechanism, National Science Foundation of China (NSFC), Regional I&R Joint Key Project, U22A20340,2023.01-2026.12,892500/2550000 RMB Yuan. Ongoing, Joint Principal Investigator.
2. 高原低氧环境下影响藏族人群遗传适合度的关键生理因素及其调控机制的多组学解析,国家自然科学项目面上项目,32070578,2021.01-2024.12,60万元,在研,主持。
Multi-omics characterization of key physiological factors that affecting genetic fitness at high altitude hypoxic environment and its regulating mechanism in Tibetan populations, National Science Foundation of China (NSFC), General Project, 32070578, 2021.01-2024.12, 600,000 RMB Yuan. Ongoing, Principal Investigator.
3. 平原人群对高原低氧环境的生理响应模式及影响习服的关键遗传与生理因素及其预警标志物筛选,西藏自治区重点研发项目,XZ202201ZY0035G,2022.05-2025.04,85万元,在研,联合主持。
Key genetic and physiological factors affecting acclimatization of lowland populations living in high altitude enviroments, R&D program of Tibetan Autonomous Region, Key Project, XZ202201ZY0035G,2022.05-2025.04, 850,000 RMB Yuan. Ongoing, Joint Principal Investigator.
4. 高原人群适应高寒环境的遗传资源发掘,中国科学院战略性科技先导项目A类,XDA20040102,2018.01-2022.09,138/670万元,在研,课题第二负责人。
Characterization of genetic and phenotypic traits underlying adaptation to high altitude and cold environment in Tibetan populations. the Strategic Priority Research Program of the Chinese Academy of Sciences, XDA20040102, 2018.01-2022.09, 1,380,000/6,700,000 RMB Yuan. Ongoing, Joint Principal Investigator.
5. 藏族人群高原低氧适应关键基因EPAS1和EGLN1互作的分子机制及功能验证研究,国家自然科学项目重大研究计划项目,91631306,2017.1-2019.12,289万元,结题,参与。
Functional validation and molecular mechanism underlying interactions of EPAS1 and EGLN1, two key genes regulating high altitude hypoxic adaptation in Tibetan populations. NSFC Key Project, 91631306, 2017.01-2019.12, 2,890,000 RMB yuan. completed, Key Participant.
6. 解析藏族人群高原肺动脉高压的调控机制及其对高原低氧环境适应的遗传效应,国家自然科学项目面上项目,31671329,2017.1-2018.12,25万元,结题,主持。
Deciphering the regulating mechanism of high altitude pulmonary arterial hypertension and their genetic effect on adaptation to high altitude hypoxic environment. National Science Foundation of China (NSFC), General Project, 31671329, 2017.01-2018.12, 250,000 RMB Yuan. completed, Principal Investigator.
7. 青藏高原史前人类定居与迁徙模式的遗传学研究,国家自然科学项目面上项目, 31371269,2014.1-2017.12, 80万元,结题,主持。
Genetic studies on prehistoric human colonization and migrations on the Qinghai-Tibetan Plateau. National Science Foundation of China (NSFC), General Project, 31371269, 2014.01-2017.12, 800,000 RMB Yuan. completed, Principal Investigator.
8. 慢性高原低氧损伤与长期适应的分子机制研究,国家重点基础研究计划(973)课题,2012CB518202,2012.1-2016.8,532万元,结题,子课题负责人。
Molecular mechanism underlying physiological acclimatization and adaptation to high altitude hypoxic environment. National Key Basic Research Program (973 project), 2012CB518202, 2012.01-2016.08, 5,320,000 RMB Yuan. completed, Joint Principal Investigator.
9. 家养牦牛的起源、驯化与群体扩散的遗传学研究,国家自然科学基金面上项目, 30870295,2009.1-2011.12,33万元,结题,主持。
Deciphering the epidemiological patterns of high altitude deterioration and its impact factors and regulative mechanism, National Science Foundation of China (NSFC),Regional I&R Joint Key Project, U22A20340,2023.01-2026.12,892500/2550000 RMB Yuan. Ongoing, Joint Principal Investigator.
六、获奖情况
1. 2022年:西藏自治区科学技术奖一等奖,藏族人群对高原低氧环境的生理适应特征及其调控机制,(第三完成人)。
2. 2015年:西藏自治区科学技术奖二等奖,青藏高原史前人类定居历史及其对高原低氧环境的遗传适应机制,编号2015-JG-2-07-05,(第五完成人)。
3. 2013:云南省自然科学奖一等奖,灵长类大脑进化与人类智力起源的遗传机制,编号2013MA166-R-003(第三完成人)。
七、代表性论文 Representative papers