• 祁学斌(Xuebin Qi

    昆明理工大学灵长类转化医学研究院,

    省部共建非人灵长类生物医学国家重点实验室

    副教授,遗传分析与测序平台负责人

    Associate Professor,Principal Investigator for Genetic Analysis and Sequencing Platform

    State Key Laboratory of Primate Biomedical Research (LPBR)

    School of Primate Translational Medicine

    Kunming University of Science and Technology (KUST)

    一、教育及工作经历 Education and Academic Positions

    • 1993年9月 - 1997年6月,甘肃农业大学,动物生产工程系,畜牧专业,农学学士
    • 1997年9月 - 2000年6月,甘肃农业大学,动物生产工程系,动物遗传育种与繁殖专业,农学硕士
    • 2000年9月 - 2004年6月,兰州大学,生命科学学院,生态学专业,理学博士(其间2001年1月-2004年6月,International Livestock Research Institute,ILRI-Nairobi, Kenya,PhD Graduate Fellow)
     
    • Sept. 1997- June 2000, Gansu Agricultural University, Major in Animal Genetics, Breeding and Reproduction, MSc of Agriculture.
    • Sept. 2000- June 2004, Lanzhou University, Major in Ecology, PhD.(Feb. 2001-June 2004, International Livestock Research Institute, ILRI-Nairobi, Kenya, PhD Graduate fellow)
    • Sept. 1993- June 1997, Gansu Agricultural University, Major in Animal Science, Bachelor of Agriculture.

    二、工作经历 Work Experience

    • 2022年01月 – 至今,昆明理工大学,灵长类转化医学研究院,副教授
    • 2014年01月 – 2022年01月,中国科学院昆明动物研究所,遗传资源与进化国家重点实验室,副研究员
    • 2007年01月 – 2013年12月,中国科学院昆明动物研究所,遗传资源与进化国家重点实验室,助理研究员
    • 2004年10月 - 2006年12月,中国科学院昆明动物研究所,细胞与分子进化重点实验室,博士后
    • 2004年06月 - 2004年09月,国际家畜研究所,肯尼亚,内洛比,访问学者

     

    • Jan. 2022-present, Associate Professor, School of Primate Translational Medcine, Kunming University of Science and Technology.
    • Jan. 2014-Jan. 2022, Associate Professor, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences.
    • Jan. 2007-Dec. 2013, Assistant Professor, State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences.
    • Oct. 2004-Dec. 2006, Postdoctoral Fellow, Key Laboratory of Cellular and Molecular Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences.
    • June 2004-Sept. 2004, Visiting Scientist, International Livestock Research Institute, Nairobi, Kenya.

    三、主要研究方向 Main Research Directions

    1.遗传分析与测序平台

    Genetic Analysis and Sequencing Platform

    2.灵长类基因组多样性与疾病

    Primate Genome Diversity and Disease

    3.低氧习服与适应机制

    Mechanism underlying acclimatization and adaptation to hypoxia

    四、科研领域描述 Description of Scientific Research

    1.遗传分析与测序平台

    建立包括单细胞测序在内的各种多组学测序文库构建技术、多组学数据质控与分析流程、多组学功能元件发掘等组学分析方法,为灵长类转化医学研究院提供高质量的组学建库与测序技术支撑。

    Establishing Genetic Analyses and Sequencing Platform support for School of Primate Translational Medicine, including multi-omics library construction, quality control and analytical pipeline for sequencing data, data mining for functional genomic elements in primates etc..

     

    2、灵长类基因组多样性及其对低氧环境的习服与适应机制

    利用多组学技术解析灵长类基因组多样性及其对低氧环境的习服与适应机制

    Deciphering genomic diversity in primates and genomic mechanism underlying acclimatization and adaptation to hypoxia.

    五、承担科研项目情况 Research Projects

    1.高原低氧环境下影响藏族人群遗传适合度的关键生理因素及其调控机制的多组学解析,国家自然科学项目面上项目,32070578,2021.01-2024.12,60万元,在研,主持。

    Multi-omics characterization of key physiological factors that affecting genetic fitness at high altitude hypoxic environment and its regulating mechanism in Tibetan populations, National Science Foundation of China (NSFC), General Project, 32070578, 2021.01-2024.12, 600,000 RMB Yuan. Ongoing, Principal Investigator.

     

    2.高原人群适应高寒环境的遗传资源发掘,中国科学院战略性科技先导项目A类,XDA20040102,2018.01-2022.09,138万元,在研,课题第二负责人。

    Characterization of genetic and phenotypic traits underlying adaptation to high altitude and cold environment in Tibetan populations. the Strategic Priority Research Program of the Chinese Academy of Sciences, XDA20040102, 2018.01-2022.09, 1,380,000 RMB Yuan. Ongoing, Joint Principal Investigator.

     

    3.藏族人群高原低氧适应关键基因EPAS1和EGLN1互作的分子机制及功能验证研究,国家自然科学项目重大研究计划项目,91631306,2017.1-2019.12,289万元,结题,参与。

    Functional validation and molecular mechanism underlying interactions of EPAS1 and EGLN1, two key genes regulating high altitude hypoxic adaptation in Tibetan populations. NSFC Key Project, 91631306, 2017.01-2019.12, 2,890,000 RMB yuan. completed, Key Participant.

     

    4.解析藏族人群高原肺动脉高压的调控机制及其对高原低氧环境适应的遗传效应,国家自然科学项目面上项目,31671329,2017.1-2018.12,25万元,结题,主持。

    Deciphering the regulating mechanism of high altitude pulmonary arterial hypertension and their genetic effect on adaptation to high altitude hypoxic environment. National Science Foundation of China (NSFC), General Project, 31671329, 2017.01-2018.12, 250,000 RMB Yuan. completed, Principal Investigator.

     

    5.青藏高原史前人类定居与迁徙模式的遗传学研究,国家自然科学项目面上项目, 31371269,2014.1-2017.12, 80万元,结题,主持。

    Genetic studies on prehistoric human colonization and migrations on the Qinghai-Tibetan Plateau. National Science Foundation of China (NSFC), General Project, 31371269, 2014.01-2017.12, 800,000 RMB Yuan. completed, Principal Investigator.

     

    6.慢性高原低氧损伤与长期适应的分子机制研究,国家重点基础研究计划(973)课题,2012CB518202,2012.1-2016.8,532万元,其中本人经费186.40万元,结题,子课题负责人。

    Molecular mechanism underlying physiological acclimatization and adaptation to high altitude hypoxic environment. National Key Basic Research Program (973 project), 2012CB518202, 2012.01-2016.08, 5,320,000 RMB Yuan. completed, Joint Principal Investigator.

     

    7.家养牦牛的起源、驯化与群体扩散的遗传学研究,国家自然科学基金面上项目, 30870295,2009.1-2011.12,33万元,结题,主持。

    Genetic study on origins, domestication and dispersal of domestic yak. National Science Foundation of China (NSFC), General Project, 30870295, 2009.01-2011.12, 330,000 RMB Yuan. completed, Principal Investigator.

    六、获奖情况

    1. 2015年:西藏自治区科学技术奖二等奖,青藏高原史前人类定居历史及其对高原低氧环境的遗传适应机制,编号2015-JG-2-07-05,(第五)。
    2. 2013:云南省自然科学奖一等奖,灵长类大脑进化与人类智力起源的遗传机制,编号2013MA166-R-003(第三)。

    七、代表性论文 Representative papers

    1. He, Y.#, Li, J.#, Yue, T.#, Zheng, W.#, Guo, Y.#, Zhang, H., Chen, L., Li, C., Li, H., Cui, C., Ouzhuluobu*, Qi, X.* & Su, B.* Seasonality and Sex-Biased Fluctuation of Birth Weight in Tibetan Populations. Phenomics DOI: 10.1007/s43657-021-00038-7 (2022).
    2. Ouzhuluobu#, He, Y.#, Lou, H.#, Cui, C.#, Deng, L#., Gao, Y., Zheng, W., Guo, Y., Wang, X., Ning, Z., Li, J., Li, B., Bai, C., Baimakangzhuo, Gonggalanzi, Dejiquzong, Bianba, Duojizhuoma, Liu, S., Wu, T., Xu, S.*, Qi, X.* & Su, B.* De novo assembly of a Tibetan genome and identification of novel structural variants associated with high altitude adaptation. National Science Review, 7:391–402 (2020).
    3. Qi, X.#, Zhang, Q.#, He, Y.#, Yang, L.#, Zhang, X., Shi, P., Yang, L., Liu, Z., Zhang, F., Liu, F., Liu, S., Wu, T., Cui, C., Ouzhuluobu, Bai, C., Baimakangzhuo, Han, J., Zhao, S., Liang, C. & Su, B.* The Transcriptomic Landscape of Yaks Reveals Molecular Pathways for High Altitude Adaptation. Genome Biol Evol 11, 72-85 (2019).
    4. Peng, Y.#, Cui, C.#, He, Y.#, Ouzhuluobu#, Zhang, H.#, Yang, D.#, Zhang, Q.#, Bianbazhuoma, Yang, L., He, Y., Xiang, K., Zhang, X., Bhandari, S., Shi, P., Yangla, Dejiquzong, Baimakangzhuo, Duojizhuoma, Pan, Y., Cirenyangji, Baimayangji, Gonggalanzi, Bai, C., Bianba, Basang, Ciwangsangbu, Xu, S., Chen, H., Liu, S., Wu, T.*, Qi, X.* & Su, B.* Down-regulation of EPAS1 transcription and genetic adaptation of Tibetans to high-altitude hypoxia. Mol Biol Evol 34, 818-830 (2017).
    5. Zhang, H.#, He, Y.#, Cui, C.#, Ouzhuluobu, Baimakangzhuo, Duojizhuoma, Dejiquzong, Bianba, Gonggalanzi, Pan, Y., Qula, Kangmin, Cirenyangji, Baimayangji, Bai, C., Guo, W., Yangla, Peng, Y., Zhang, X., Xiang, K., Yang, Z., Liu, S., Tao, X., Gengdeng, Zheng, W., Guo, Y., Wu, T., Qi, X.* & Su, B.* Cross-altitude analysis suggests an elevation turning point of 4,500m for polycythemia incidence in Tibetans. American Journal of Hematology 92(9): E552-E554 (2017), DOI: 10.1002/ajh.24809.
    6. Qi, X.#, Cui, C.#, Peng, Y.#, Zhang, X.#, Yang, Z.#, Zhong, H., Zhang, H., Xiang, K., Cao, X., Wang, Y., Ouzhuluobu, Basang, Ciwangsangbu, Bianba, Gonggalanzi, Wu, T., Chen, H., Shi, H. & Su, B. Genetic evidence of Paleolithic colonization and Neolithic expansion of modern humans on the Tibetan Plateau. Molecular Biology and Evolution 30, 1761-78 (2013).
    7. Xiang, K.#, Ouzhuluobu#, Peng, Y.#, Yang, Z., Zhang, X., Cui, C., Zhang, H., Li, M., Zhang, Y., Bianba, Gonggalanzi, Basang, Ciwangsangbu, Wu, T., Chen, H., Shi, H., Qi, X.* & Su, B.* Identification of a Tibetan-specific mutation in the hypoxic gene EGLN1 and its contribution to high-altitude adaptation. Molecular Biology and Evolution 30, 1889-98 (2013).
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