副教授、研究员、硕士研究生导师
一、教育与工作经历 Education and working experiences
二、主要研究方向 Research Interests
三、科研领域描述 RESEARCH FILEDS
老年痴呆和帕金森病是排名前两位的神经退行性疾病,目前对这些疾病的发病机理不清,也没有有效的治疗手段。当前临床上的一些药物主要是基于啮齿类等低等动物的实验数据,所以很多药物在这些动物模型效果显著,但是临床上效果不佳或者根本效果,这可能是由于这些实验动物在生理结构和行为表型上与人存在巨大差异造成的。因此选择与人类有十分相似的脑结构与功能系统、且与人类基因相似度高达97.5%,具有推理、分析、决策、记忆等人类高级脑功能的非人灵长类动物作为实验动物,建立退行性模型,在此基础上开展疾病发病机理和治疗研究。
Alzheimer's disease (AD) and Parkinson's disease (PD) are the top two neurodegenerative diseases. The cause and precise pathological mechanism of AD and PD remains unclear. Most of the current clinical drugs are mainly based on experimental data of experimental animals such as rodents. Due to the dramatic differences in physiological structures and behavioral phenotypes between the animals and human beings, these drugs are effective in the animal models, but most are failed in clinical trials. Compared to rodents that are inbred, nonhuman primates (NHPs are outbred. Behavioral outcome measures such as fine motor skills, which are affected in PD, can be easily tested in NHPs but not in other large species, like pigs. Clinically relevant behavioral outcome measures are critical to determine the efficacy of the strategy. The NHPs, whose brain morphology and function like human beings, are used to develop new models that may be more suitable for preclinical therapeutic development.
四、承担科研项目情况 Fundings
五、代表性论文和专著
六、授权发明专利 Patents
七、招聘招生
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