王正波 (Zhengbo Wang)

• 教育经历

1. 1997.9-2001.6：长江大学，农学学士
2. 2001.9-2004.6：甘肃农业大学动物医学院，基础兽医学，获得农学硕士学位
3. 2004.9-2007.6：甘肃农业大学动物医学院，基础兽医学，获得农学博士学位

1. 1997.09-2001.06: Department of Animal Science, Hubei Agricultural College, B.S. in agriculture
2. 2001.09-2004.06: College of Veterinary Medicine, Gansu Agricultural University, M.A. in agriculture
3. 2004.09-2007.06: College of Veterinary Medicine, Gansu Agricultural University, Ph.D in agriculture

• 工作经历

1. 2018.8至今：昆明理工大学灵长类转化医学研究院，副教授
2. 2017.1-2018.8：中科院昆明动物研究所，副研究员
3. 2010.10-2016.12：中科院昆明动物研究所，助理研究员
4. 2007.8-2010.9：中国科学院动物模型与人类疾病机理重点实验室，博士后，神经生物学，合作导师：胡新天研究员

1. 2007.08-2010.08: Post-doctoral, Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province (AMHD), Chinese Academy of Sciences
2. 2010.10-2016.12: Assistant professor, Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province (AMHD), Chinese Academy of Sciences
3. 2017.01-2018.12: Associate professor, Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province (AMHD), Chinese Academy of Sciences
4. 2018.12-Now: Associate Professor, Institute of Primate Translational Medicine, Kunming University of Science and Technology
5. 2018.12-Now: Yunnan Key Laboratory of Primate Biomedical Research, Professor

老年痴呆和帕金森病是排名前两位的神经退行性疾病，目前对这些疾病的发病机理不清，也没有有效的治疗手段。当前临床上的一些药物主要是基于啮齿类等低等动物的实验数据，所以很多药物在这些动物模型效果显著，但是临床上效果不佳或者根本效果，这可能是由于这些实验动物在生理结构和行为表型上与人存在巨大差异造成的。因此选择与人类有十分相似的脑结构与功能系统、且与人类基因相似度高达97.5％，具有推理、分析、决策、记忆等人类高级脑功能的非人灵长类动物作为实验动物，建立退行性模型，在此基础上开展疾病发病机理和治疗研究。

Alzheimer's disease (AD) and Parkinson's disease (PD) are the top two neurodegenerative diseases. The cause and precise pathological mechanism of AD and PD remains unclear. Most of the current clinical drugs are mainly based on experimental data of experimental animals such as rodents. Due to the dramatic differences in physiological structures and behavioral phenotypes between the animals and human beings, these drugs are effective in the animal models, but most are failed in clinical trials. Compared to rodents that are inbred, nonhuman primates (NHPs are outbred. Behavioral outcome measures such as fine motor skills, which are affected in PD, can be easily tested in NHPs but not in other large species, like pigs. Clinically relevant behavioral outcome measures are critical to determine the efficacy of the strategy. The NHPs, whose brain morphology and function like human beings, are used to develop new models that may be more suitable for preclinical therapeutic development.

1. 云南省中青年学术带头人后备人才，2020-2024，12万，主持；
2. 国家重点研发计划项目：发育代谢复杂疾病灵长类动物模型的创制与临床前研究，2018YFA0801403，2019-2024，224.1万元，子课题组长
3. 国家自然科学基金地区基金项目，31960120，基于非人灵长类猕猴PD模型神经干细胞黑质原位移植治疗研究，2020.1-2023.12，40万，主持
4. 云南省自然科学基金面上项目，猕猴黑质神经干细胞移植存活、分化及投射研究，2018.1-2021.12，10万，主持
5. 973项目，2015CB755605，灵长类模型神经回路成像研究，2015.1-2019.8，349.4万，子课题组长
6. 国家自然科学基金面上项目，81771387，阿尔兹海默病（AD）猕猴自发模型的筛选鉴定，2018/01-2021/12，80万，参加
7. 国家自然科学基金面上项目，81471312，建立阿尔茨海默病（AD）转基因猴模型，2015/01-2018/12，150万元，参加
8. 中国科学院战略性先导科技专项（B类），XDB02020500，学习与记忆相关脑区之间的神经网络活动规律，2012/01-2016/12，866万，课题骨干
9. 973项目，2007CB947703，猕猴神经干细胞转化为神经元过程中，功能性回路形成的特征研究，2007.1-2010.8，538.95万，课题骨干

1. National Key Research and Development Project （2018YFA0801400）, 2019-2024，2，241，000，Co-PI
2. Natural Science Foundation of China (31960120, 2017-2020, ￥400,000, PI.
3. 2018-2021: “Study of Survival, differentiation and projection of macaque substantia nigra neural stem cell transplantation”, Project on Yunnan Natural Science Foundation,(Grant No. 2018FB052) , 100，000，PI
4. 2015-2018: “Imaging study of primate model neural circuit”, 973 Project,(Grant No.2015CB755605),3，494，000 Sub-PI
5. 2018-2021: “Screening and Identification of Spontaneous Model of Alzheimer's Disease in Macaque”, NSFC, (Grant No. 81771387), 80,000；principal member

1. Li H(#), Gan X(#), Pan L(#), Zhang Y, Hu X(*), Wang Z(*). EGF/bFGF promotes survival, migration and differentiation into neurons of GFP-labeled rhesus monkey neural stem cells xenografted into the rat brain. Biochem Biophys Res Commun. 2022 Sep 10; 620:76-82. doi: 10.1016/j.bbrc.2022.06.077. Epub 2022 Jun 25.

2. Zhu R(#), Luo Y(#), Li S(*), Wang Z(*) . The role of microglial autophagy in Parkinson's disease. Front Aging Neurosci. 2022 Nov 1; 14:1039780. doi: 10.3389/fnagi.2022.1039780. eCollection 2022.

3. Mengjia Li(#), Zhengbo Wang(#), Tianzhuang Huang, Tianqi Zheng, Baoguo Liu, Deqiang Han, Sumei Liu, Mo Li, Wei Si, Yu Alex Zhang(*), Yuyu Niu(*), Zhiguo Chen(*).Characterization of human induced neural stem cells and derivatives following transplantation into the central nervous system of a nonhuman primate and rats. Stem cell international, Volume 2022 | Article ID 1396735

4. Lu S, Chen Y(*), Wang Z(*). Advances in the pathogenesis of Rett syndrome using cell models. Animal Model Exp Med. 2022 Dec;5(6):532-541. doi: 10.1002/ame2.12236. Epub 2022 Jul 4.

5. Wang J(#), Wang Z(#),Zhang H(#), Feng S(#),Lu Y(#), Wang S, Wang H, Sun YE, Chen Y(*). White Matter Structural and Network Topological Changes Underlying the Behavioral Phenotype of MECP2 Mutant Monkeys. Cereb Cortex. 2021 Jun 12;bhab166.

6. Xu K(#), Chen D(#), Wang Z(#), Ma J, Zhou J, Chen N, Lv L, Zheng Y, Hu X, Zhang Y(*), Li J(*). Annotation and functional clustering of circRNA expression in rhesus macaque brain during aging. Cell Discov. 2018 Sep 18;4:48. doi: 10.1038/s41421-018-0050-1. eCollection 2018.

7. Zhai R, Rizak J, Zheng N, He X, Li Z, Yin Y, Su T, He Y, He R, Ma Y, Yang M(*), Wang Z(*), Hu X(*). Alzheimer's Disease-Like Pathologies and Cognitive Impairments Induced by Formaldehyde in Nonhuman Primates. Curr Alzheimer Res. 2018 Sep 4. doi: 10.2174/1567205015666180904150118. [Epub ahead of print]

8. Huang B(#), Wu S(#), Wang Z(#), Ge L, Rizak JD, Wu J, Li J, Xu L, Lv L(*), Yin Y(*), Hu X(*), Li H(*). Phosphorylated α-Synuclein Accumulations and Lewy Body-like Pathology Distributed in Parkinson's Disease-Related Brain Areas of Aged Rhesus Monkeys Treated with MPTP. Neuroscience. 2018 May 21;379:302-315.

9. Liu S(#), Wang Z(#), Chen D(#), Zhang B(#), Tian RR(#), Wu J, Zhang Y, Xu K, Yang LM, Cheng C, Ma J, Lv L, Zheng YT, Hu X, Zhang Y(*), Wang X(*), Li J(*). Annotation and cluster analysis of spatiotemporal- and sex-related lncRNA expression in rhesus macaque brain. Genome Res. 2017 Sep;27(9):1608-1620.

10. Wang ZB(#), Qin DD(#), Hu XT. Engrafted newborn neurons could functionally integrate into the host neuronal network. Zool Res. 2017 Jan 18;38(1):5-6.

11. Huma T(*), Hu X, Ma Y, Willden A, Rizak J, Shahab M, Wang Z(*). Kisspeptin-10 treatment generated specific GnRH expression in cells differentiated from rhesus monkey derived Lyon NSCs. Neuroscience. 2017 May 4;349:318-329.

12. Wei JK(#), Wang WC(#), Zhai RW(#), Zhang YH, Yang SC, Rizak J, Li L, Xu LQ, Liu L, Pan MK, Hu YZ, Ghanemi A, Wu J, Yang LC, Li H, Lv LB, Li JL, Yao YG, Xu L, Feng XL, Yin Y, Qin DD, Hu XT(*), Wang ZB(*). Neurons Differentiated from Transplanted Stem Cells Respond Functionally to Acoustic Stimuli in the Awake Monkey Brain. Cell Rep. 2016 Jul 26;16(4):1016-1025.

13. Li H(#) ，Lei X(#) ，Yan T (#)，Li H，Huang B，Li L，Xu L，Liu L，Chen N，Lü L，Ma Y，Xu L，Li J，Wang Z(*)，Zhang B(*)，Hu X(*)，The temporary and accumulated effects of transcranial direct current stimulation for the treatment of advanced Parkinson's disease monkeys，Sci Rep，2015，5：12178.

14. Guo L, Wei J, Yang S, Wang Z(*). Glaucoma model for stem cell transplantation research in New Zealand white rabbits.Dongwuxue Yanjiu. 2012 Apr;33(2):225-30. doi: 10.3724/SP.J.1141.2012.02225. Chinese.

15. Dong J, Guo L, Qu J, Qi R, Wang W, Xiao C(*), Wang Z(*). Rhesus monkey embryonic stem cells differentiation, proliferation and allotransplantation. Dongwuxue Yanjiu. 2012 Feb;33(1):43-8. doi: 10.3724/SP.J.1141.2012.01043. Chinese.

16. Yang S, Dong J, Qu J, Hu X, Wang Z(*). A traumatic brain injury model for distinguishing between transplanted neural cells and host cells in vivo. Dongwuxue Yanjiu. 2011 Aug;32(4):421-7. doi: 10.3724/SP.J.1141.2011.04421. Chinese.

17. Li ML, Wu SH, Zhang JJ, Tian HY, Shao Y, Wang ZB, Irwin DM, Li JL, Hu XT, Wu DD. 547 Transcriptomes From 44 Brain Areas Reveal Features of the Aging Brain in Non-Human Primates. Genome Biol. 2020 Feb 24;21(1):46. doi: 10.1186/s13059-020-01962-z.

18. Qin D, Li Z, Li Z, Wang L, Hu Z, Lü L, Wang Z, Liu Y, Yin Y, Li Z, Hu X. Chronic Glucocorticoid Exposure Induces Depression-Like Phenotype in Rhesus Macaque (Macaca Mulatta). Front Neurosci. 2019 Mar 8;13:188. doi: 10.3389/fnins.2019.00188. eCollection 2019.

19. Ye L, Zhao H, Zhou H, Ren X, Liu L,Newton O.Otecko, Wang Z, Yang M, Zeng L, Hu X, Yao Y, Zhang Y, Wu D. The RNA editome of Macaca mulatta and functional characterization of RNA editing in mitochondria. Science Bulletin Volume 62, Issue 12, 30 June 2017, Pages 820-830

20. He X, Li Z, Rizak JD, Wu S, Wang Z, He R, Su M, Qin D, Wang J, Hu X. Resveratrol Attenuates Formaldehyde Induced Hyperphosphorylation of Tau Protein and Cytotoxicity in N2a Cells. Front Neurosci. 2017 Jan 31;10:598.

21. Ye L, Bian H, Fan Y, Wang Z, Yu H, Ma Y, Chen F. Rhesus monkey neural stem cell transplantation promotes neural regeneration in rats with hippocampal lesions. Neural Regen Res. 2016 Sep;11(9):1464-1470.

22. Yang W, Wang G, Wang CE, Guo X, Yin P, Gao J, Tu Z, Wang Z, Wu J, Hu X, Li S, Li XJ. Mutant alpha-synuclein causes age-dependent neuropathology in monkey brain. J Neurosci. 2015 May 27;35(21):8345-58.

23. Lei X, Li H, Huang B, Rizak J, Li L, Xu L, Liu L, Wu J, Lü L, Wang Z, Hu Y, Le W, Deng X, Li J, Yao Y, Xu L, Hu X, Zhang B. 1-methyl-4-phenylpyridinium stereotactic infusion completely and specifically ablated the nigrostriatal dopaminergic pathway in rhesus macaque. PLoS One. 2015 May 26;10(5):e0127953.

24. Li H, Lei X, Huang B, Rizak JD, Yang L, Yang S, Wu J, Lü L, Wang J, Yan T, Li H, Wang Z, Hu Y, Le W, Deng X, Li J, Xu L, Zhang B, Hu X. A quantitative approach to developing Parkinsonian monkeys (Macaca fascicularis) with intracerebroventricular 1-methyl-4-phenylpyridinium injections. J Neurosci Methods. 2015 Aug 15;251:99-107.

25. Yang M, Miao J, Rizak J, Zhai R, Wang Z, Huma T, Li T, Zheng N, Wu S, Zheng Y, Fan X, Yang J, Wang J, Yang S, Ma Y, Lü L, He R, Hu X. Alzheimer's disease and methanol toxicity (part 2): lessons from four rhesus macaques (Macaca mulatta) chronically fed methanol. J Alzheimers Dis. 2014;41(4):1131-47.

26. Huma T, Wang Z, Rizak J, Ahmad F, Shahab M, Ma Y, Yang S, Hu X. Kisspeptin-10 modulates the proliferation and differentiation of the rhesus monkey derived stem cell line: r366.4. Scientific World Journal. 2013 Nov 28;2013:135470

27. Wu J, Wang W, Rizak JD, Wang Z, Wang J, Feng X, Dong J, Li L, Liu L, Xu L, Yang S, Hu X. A new method for piercing the tentorium cerebelli for implanting fragile electrodes into the brain stem in the rhesus monkey (Macaca mulatta). J Neurophysiol. 2013 Dec 11

28. Chen Y, Wang Z, Xie Y, Guo X, Tang X, Wang S, Yang S, Chen K, Niu Y, Ji W. Folic acid deficiency inhibits neural rosette formation and neuronal differentiation from rhesus monkey embryonic stem cells. J Neurosci Res. 2012 Jul;90(7):1382-91. doi: 10.1002/jnr.23030. Epub 2012 Mar 13.

29. Ni J, Jiang H, Jin Y, Chen N, Wang J, Wang Z, Luo Y, Ma Y, Hu X. Dissociable modulation of overt visual attention in valence and arousal revealed by topology of scan path. PLoS One. 2011 Apr 6;6(4):e18262. doi: 10.1371/journal.pone.0018262.

1. 杨上川，张玉华，胡新天，王正波，胡英周，用于磁共振的大动物头部固定装置（申请号: 201320520310.7），中国， ZL 201320520310.7。
2. 杨上川，胡新天，王正波，吴晶，双向微电极推进器及微电极（申请号:201320190992.X），中国， ZL 201320190992.X。
3. 杨上川，胡新天，王正波，胡英周，用于大动物立体定位仪的耳杆高度可调耳杆座（申请号:201320175021.8），中国， ZL 201320175021.8.
4. 杨上川，胡新天，王正波，王文超，马原野脑微量组织取样器（申请号:201210110829.8），中国， ZL 201210110829.8。
5. 黄田庄，王宏，司维，段艳超，王正波，邱帅，龚南南，何羽群，一种做黑磁共振扫描时食蟹猴的下肢及膝关节固定装置, 2022-3-1, 中国, ZL202122125047.9 (专利)