一、教育与工作经历 Education and working experiences
二、主要研究方向 Research Interests
三、科研领域描述 RESEARCH FILEDS
Alzheimer's disease (AD) and Parkinson's disease (PD) are the top two neurodegenerative diseases. The cause and precise pathological mechanism of AD and PD remains unclear. Most of the current clinical drugs are mainly based on experimental data of experimental animals such as rodents. Due to the dramatic differences in physiological structures and behavioral phenotypes between the animals and human beings, these drugs are effective in the animal models, but most are failed in clinical trials. Compared to rodents that are inbred, nonhuman primates (NHPs are outbred. Behavioral outcome measures such as fine motor skills, which are affected in PD, can be easily tested in NHPs but not in other large species, like pigs. Clinically relevant behavioral outcome measures are critical to determine the efficacy of the strategy. The NHPs, whose brain morphology and function like human beings, are used to develop new models that may be more suitable for preclinical therapeutic development.