• 杨泽斌（Zebin Yang）

    云南省“兴滇英才支持计划”-青年人才

    昆明理工大学高层次人才引进

    博士，副教授，硕士研究生导师

    Ph.D., Associate Professor

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    一、教育及工作经历（Education and Academic Positions）

    • 2022.09-至今 昆明理工大学灵长类转化医学研究院，副教授，硕士生导师
    • 2019.01-2022.06 中国科学院上海硅酸盐研究所，联合培养博士
    • 2018.09-2022.06 同济大学，化学，理学博士
    • 2015.09-2018.06 昆明理工大学，材料学，工学硕士

    • ep 2022-present Institute of Primate Translational Medicine, Kunming University of Science and Technology, Associate Professor.
    • Jan 2019-June 2022 joint Ph.D., Shanghai Institute of Ceramics, Chinese Academy of Sciences.
    • Sep 2018-June 2022 Ph.D., Chemistry, Tongji University.
    • Sep 2015-June 2018 M.S., Materials Science, Kunming University of Science and Technology.

    二、主要研究方向（Main Research Directions）

    1. 智能响应型纳米递送系统的构建
    2. 肿瘤免疫微环境的重塑研究
    3. 基于CRISPR/Cas9编辑技术在疾病的体内靶向治疗
    4. 探究衰老及其相关疾病的致病机制和体内基因治疗

    1. Construction of intelligent responsive nano-delivery system
    2. Focus on the remodeling of tumor immune microenvironment
    3. Targeted therapy in-vivo of diseases based on CRISPR/Cas9 editing technology
    4. Exploring the pathogenic mechanisms and in-vivo gene therapy for aging and its associated diseases

    三、科研领域描述（Description of Scientific Research）

    1. 肿瘤免疫抑制微环境是诱导肿瘤复发转移的根本原因。综合纳米技术、材料学和生物医学，以药物或基因技术（CRISPR/Cas9）作为手段，通过构建智能响应型纳米递送系统，实现对肿瘤免疫微环境的有效调控，降低癌症的复发转移。为临床的精准、安全、有效的癌症治疗提供一种新的思路。
    2. 衰老及衰老产生的相关疾病严重影响人类的生命健康，机体的衰老可分为正常衰老和病理性衰老。在病理性衰老中，哈钦森-吉尔福德儿童早衰症（HGPS）是一类以加速衰老为主要特征的单碱基突变遗传性疾病，大多数HGPS患者平均寿命仅为14.6岁，通常死于心血管疾病和动脉粥样硬化等相关疾病，目前尚无有效治疗方法。通过构建智能靶向纳米递送系统，实现对HGPS患者体内靶向单碱基编辑治疗，改善患者症状和延长寿命，为临床HGPS治疗提供新的借鉴。

    1. The tumor immunosuppressive microenvironment is the primary cause of cancer metastasis and recurrence. Integrating nanotechnology, materials science and biomedicine, using drugs or gene technology (CRISPR/Cas9) as a means, employing the intelligent responsive nano-delivery system to achieve the effective regulation of the tumor immune microenvironment, and reduce the recurrence and metastasis of cancer. It provides a new idea for precise, safe and effective therapy of cancer.
    2. Aging and diseases associated with aging have a serious impact on human life and health, and the aging of the organism can be divided into normal aging and pathological aging. Among pathological aging, Hutchinson-Guilford premature senescence in children (HGPS) is a class of genetic diseases characterized by accelerated aging with single-base mutations, and the average life expectancy of most of the HGPS patients is only 14.6 years, and they usually die of cardiovascular diseases and atherosclerosis, etc. There is currently no effective treatment for HGPS. By constructing an intelligent targeted nano-delivery system, we can realize in vivo targeted single-base editing therapy for HGPS patients to improve their symptoms and prolong their lifespan, which will provide a new idea for clinical HGPS treatment.

    四、承担项目（Research Funding）

    1. 国家自然科学基金，青年基金（32401185），2025.01-2027.12，30万，在研，主持
    2. 云南省“兴滇英才支持计划”-青年人才专项，2025.01-2029.12，70万，在研，主持
    3. 云南省科技厅，昆明理工大学“双一流”创建联合专项—重点项目(202301BE070001-001)，2023.12-2026.11，100万，在研，主持
    4. 云南省科技厅，基础研究专项—面上项目（202401CF070103），2024.06-2027.05，10万，在研，主持

    五、荣誉与学术职务（Honors and academicpositions）

    1. 云南省“兴滇英才支持计划”-青年人才
    2. VIEW期刊-青年编委
    3. WILEY出版社：“Open Science Excellent Author Program”

    六、代表性论文（Publications）

    1. Zebin Yang, Yu Luo, Kaicheng, Liang, Miao Wang, Qigang Wang, Bo Yin*, Hangrong Chen*. Reshaping Tumor Immune Microenvironment Based on Light Activated Nano-Platform for Efficient Cancer Therapy. Adv. Mater., 2022, 34. 2108908.（中科院 TOP 一区，IF：32.086）
    2. Zebin Yang, Yu Luo*, Yanan Hu, Kaicheng Liang, Gao He, Qian Chen, Qigang Wang, Hangrong Chen*. Photothermo-Promoted Nanocatalysis Combined with H2S-Mediated Respiration Inhibition for Efficient Cancer Therapy. Adv. Funct. Mater., 2021, 31. 2007991.（中科院 TOP 一区，IF：19.924）
    3. Zebin Yang, Wenxue Feng, Shixiong Chen, Xiaohong Li, Bo Yin, Hangrong Chen,* A non-drug chemotherapy-like synergizes with gas-/immunotherapy based on cancer cell membrane camouflage-functionalized nanoplatform., Nano Today, 2023, 51. 101912.（中科院 TOP 一区，IF：17.4）
    4. Zebin Yang, Hangrong Chen*. Construction of Multifunctional Nano-Platforms Based on Responsive Gas-Releasing for Tumor Therapeutic Application. Nano Res., 2023, 16. 3924-3938.（中科院一区，IF：10.269）
    5. Zebin Yang, Jitao Liu, Jinkun Liu, Xiliang Chen, Tingting Yan, Qinghua Chen*. Investigation on Physicochemical Properties of Graphene Oxide/Nano-Hydroxyapatite Composites and Its Biomedical Applications. J Aust Ceram Soc., 2021, 57, 625-633.
    6. Zebin Yang, Hangrong Chen*. The Recent Progress of Inorganic-Based Intelligent Responsive Nanoplatform for Tumor Theranostics. VIEW., 2022, 3. 20220009.
    7. Kaicheng Liang, Haitao Sun, Zebin Yang, Huizhu Yu, Jie Shen, Xiaolin Wang, Hangrong Chen*. Breaking the Redox Homeostasis: an Albumin-Based Multifunctional Nanoagent for GSH Depletion-Assisted Chemo-/Chemodynamic Combination Therapy. Adv. Funct. Mater., 2021. 31. 2100355.
    8. Miao Wang, Qian Chen*, Dong Xu, Zebin Yang, Jufeng Chen, Yang Zhang*, Hangrong Chen*. Self-cycling redox nanoplatform in synergy with mild magnetothermal and autophagy inhibition for efficient cancer therapy. Nano Today., 2022. 43. 101374.
    9. Jingchao Li, Dong Cui, Jiaguo Huang, Shasha He, Zebin Yang, Yan Zhang*, Yu Luo*, Kanyi Pu*. Organic Semiconducting Pro-nanostimulants for Near-Infrared Photoactivatable Cancer Immunotherapy. Angew. Chem. Int. Ed., 2019, 58, 2-10.
    10. Jufeng Chen, Fengfeng Xue*, Wenxian Du, Huizhu Yu, Zebin Yang, Qiujing Du, and Hangrong Chen*. An Endogenous H2S-Activated Nanoplatform for Triple Synergistic Therapy of Colorectal Cancer. Nano Lett., 2022, 22, 6156-6165.

    六、授权发明专利（Patents）

    1. 陈庆华; 杨泽斌; 刘继涛; 颜廷亭. 一种氧化石墨烯/纳米羟基磷灰石复合硅胶改性多孔支架材料的制备方法, 2020-4-7, 中国, 201810332226.X
    2. 陈庆华; 杨泽斌; 颜廷亭; 刘继涛. 一种纳米羟基磷灰石/氧化石墨烯复合材料的制备方法, 2019-7-16, 中国, 201710425341.7
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