• 张磊（Lei Zhang）

    副教授

    一、个人简介

    张磊，博士毕业于昆明理工大学，随后在美国Northeastern University从事博士后研究，现任昆明理工大学灵长类转化医学研究院，副教授，硕士生导师，省部共建非人灵长类生物医学国家重点实验室生物材料课题组组长。2020云南省青年千人，昆明理工大学高层次引进人才，2022云南省“兴滇人才”，国家重点研发计划骨干成员，2022昆明理工大学优秀教师。以第一作者和通讯作者在“Bioactive Materials”;“Materials & Design” ;“MAT SCI ENG C-MATER”等期刊发表SCI文章12篇，最高单篇影响因子16，授权发明专利8项其中国际专利1项。作为指导教师获云南省挑战杯铜奖2项，主持国家自然科学基金及省部级项目4项。

     

    课题组推动建立组织工程及再生医学交叉学科研究平台，结合“3D打印”、“微流控”等技术构建具有良好生物组织相容性、具有细胞介导分化功能和力学性能的功能化3D生物支架材料，用于药物、基因递送、细胞、类器官培养及组织的植入修复与再生治疗，并对灵长类动物疾病模型中的植入体进行材料学性能和生物功能评价，推动临床需求导向的新型医用材料及器械从基础科研到产业转化的全链条研究。

     

    主要从事生物材料与组织工程研究，3D打印生物活性墨水研究，生物活性组织工程支架研究。

    二、教育及工作经历

    • 2020年1月~ 昆明理工大学灵长类转化医学研究院，副教授
    • 2020年1月~ 云南中科灵长类生物医学重点实验室，副研究员
    • 2018年1月~2020年1月 美国 Northeastern University，博士后
    • 2011年9月~2017年7月 昆明理工大学，博士
    • 2007年9月~2011年7月 江西理工大学，本科

     

    • 2020~present Institute of Primate Translational Medicine, Kunming University of Science and Technology, Associate Professor
    • 2020~present Yunnan Key Laboratory of Primate Biomedical Research, Associate Professor
    • 2018~2020 Northeastern University., Boston, USA, Postdoctoral scholar
    • 2011-2017 Kunming University of Science and Technology, Ph.D
    • 2007~2011 Jiangxi University of Science and Technology, Bachelor

    三、主要研究方向 Main Research Directions

    • 生物仿生植入材料的增材制造与组织再生修复
    • 生物活性复合材料的功能设计及力学研究

     

    • Additive manufacturing of biomimetic implant biomaterial for tissue regeneration
    • Functional, structural design and mechanical study of bioactive composites

    四、研究领域描述 Research Field

    生物医用材料是用来对生物体进行诊断、治疗、修复或替换其病损组织、器官或增进其功能的材料。通过对生物活性陶瓷、合成/天然高分子、金属功能元素及其复合材料的合成与制备、改性和结构设计与控制，包扩计算机辅助设计和3D打印，构建具有良好生物组织相容性、具有细胞介导分化功能和力学性能及多孔结构的功能化三维组织工程支架材料，用于硬/软组织的植入修复与再生治疗，并对疾病动物模型中的植入体进行材料学性能和生物功能评价和检测。

     

    Biomaterials are synthetic or natural biocompatible materials, that can be used as a system or part of a system that repair, augments, or replaces any tissue, organ, or function of the body; especially, material suitable for use in prostheses that will be in contact with living tissue. By combining the bioceramics, biopolymer and biodegradable metal elements, we are expecting to explore the engineered porous 3D biomedical hard/soft tissue engineering scaffolds, which are able to seamlessly integrate bioactivity, mechanical robustness and multiple biological functions via 3D additive manufacturing.

    五、承担科研项目情况 Research Projects

    • 2016-2020 国家自然科学基金地区基金 31660262，参与
    • 2013-2016 云南省应用基础研究计划项目 201301PH00023 参与

    六、代表性论文 Representative papers

    1. Dong Junjie,Fang Dong,Zhang Lei,Shan Quan,Huang Yunchao. Gallium-doped titania nanotubes elicit anti-bacterial efficacy in vivo against Escherichia coli and Staphylococcus aureus biofilm[J]. Materialia, 2019, 5: 100209.
    2. L. Zhang, J. Tan, Z.Y. He, Y.H. Jiang, Effect of calcium pyrophosphate on microstructural evolution and in vitro biocompatibility of Ti-35Nb-7Zr composite by spark plasma sintering, Materials Science and Engineering: C，2018, 90: 8-15.
    3. Lei Zhang, Gang Zhao, Jun Tan, Zhengyuan He and Yehua Jiang, Electrochemical Behavior in Simulated Physiological Solution of Ti-Nb-Zr-Calcium Pyrophosphate Composite with Enhanced Bioactivity by Spark Plasma Sintering, Journal of the Electrochemical Society, 2018, 165(5): E221-E230.
    4. Lei Zhang，Jun Tan，Zheng-Yuan He，et al. Designing a multifunctional Ti-2Cu-4Ca porous biomaterial with favorable mechanical properties and high bioactivity [J]. Journal of Alloys and Compounds, 2017, 727.
    5. Lei Zhang，Jun Tan，Zheng-Yuan He，et al. Designing a novel functional-structural NiTi/hydroxyapatite composite with enhanced mechanical properties and high bioactivity [J]. Intermetallics, 2017:35–41.
    6. Lei Zhang，Jun Tan，Zheng-Yuan He. et al. Low elastic modulus Ti-Ag / Ti radial gradient porous alloy with high strength and large plasticity prepared by spark plasma sintering[J]. Materials Science and Engineering: A, 2017, 688: 330-337.
    7. Lei Zhang，Zheng-Yuan He，Jun Tan, et al. Rapid fabrication of function-structure-integrated NiTi alloys: Towards a combination of excellent superelasticity and favorable bioactivity [J]. Intermetallics, 2017, 82: 1-13.
    8. Lei Zhang，Zheng-Yuan He，Yu-Qin Zhang, et al. Rapidly sintering of interconnected porous Ti-HA biocomposite with high strength and enhanced bioactivity [J]. Materials Science and Engineering: C, 2016, 67: 104-114.
    9. Lei Zhang，Zheng-Yuan He，Yu-Qin Zhang, et al. Enhanced in vitro bioactivity of porous NiTi–HA composites with interconnected pore characteristics prepared by spark plasma sintering [J]. Materals & Design, 2016, 101: 170-180.
    10. Lei Zhang，Zheng-Yuan He，Ye-Hua Jiang, et al.. Mechanical behaviors of porous Ti with high porosity and large pore size prepared by one-step spark plasma sintering technique [J]. Vacuum, 2015, 122: 187-194.
    11. Lei Zhang，Zheng-Yuan He，Ye-Hua Jiang, et al. Superelastic behaviors of biomedical porous NiTi alloy with high porosity and large pore size prepared by spark plasma sintering [J]. Journal of Alloys and Compounds, 2015, 644: 513-522.
    12. Zunyu Ke, Changbo Yi, Lei Zhang, ZhengYuan He, Jun Tan, YeHua Jiang. Characterization of a new Ti-13Nb-13Zr-10Cu alloy with enhanced antibacterial activity for biomedical applications[J]. Materials Letters, 2019, 253:335-338.
    13. Zheng-yuan HE,Lei Zhang,Wen-rui SHAN,Yu-qin ZHANG,Rong ZHOU,Ye-hua JIANG,Jun TAN. Microstructure evolution, mechanical properties, and enhanced bioactivity of Ti-13Nb-13Zr based calcium pyrophosphate composites for biomedical applications[J]. Materials Science and Engineering: C, 2019, 98: 279-287.
    14. Zheng-Yuan He, Lei Zhang, Wen-Rui Shan, et al. Mechanical and corrosion properties of Ti-35Nb-7Zr- x HA composites fabricated by spark plasma sintering[J]. Transactions of Nonferrous Metals Society of China, 2017, 27(4):848-856.
    15. Zheng-Yuan He, Lei Zhang, Wen-Rui Shan, Yu-Qin Zhang, Ye-Hua Jiang, Rong Zhou & Jun Tan. Characterizations on Mechanical Properties and In Vitro Bioactivity of Biomedical Ti–Nb–Zr–CPP Composites Fabricated by Spark Plasma Sintering [J]. Acta Metallurgica Sinica -English Letters, 2016, 29(11): 1073-1080.
    16. Z. D. Meng, W. Liu, Y. Q. Zhang, L. Zhang, X. Tang, X. Y. Lian, H. Xie, L. Li, C. J. Wang. Porous Sr-containing hydroxyapatite enhances the proliferation and differentiation of BMSCs and osteoblast-like cells for osteogenesis in vitro [J]. Journal of Biomaterials and Tissue Engineering, 2017,7(4):283-290.

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