• 朱楚洪(Chuhong Zhu)

    陆军军医大学国家重点培育学科人体解剖学教研室主任

    重庆市生物力学重点实验室、国家发改委组织工程国家地方联合工程实验室血管组织工程中心、血管植入物国家地方联合工程实验室人工血管中心主任

    一、受教育及工作经历 Education And Professional Experience

    学习经历

    • 2008/11-2009/11 美国明尼苏达大学,Lillehei Heart Institute,访问学者
    • 1998/09-2003/07 第三军医大学,基础部人体解剖学教研室,博士
    • 1991/09-1996/07 第三军医大学,临床医学五年制本科毕业,获学士学位

    工作经历

    • 2010/11-至今 陆军军医大学人体解剖学教研室 主任
    • 2008/09-至今 陆军军医大学人体解剖学教研室、教授
    • 2005/07-2008/09 第三军医大学,基础部人体解剖学教研室,副教授
    • 2003/07-2005/07 第三军医大学,基础部人体解剖学教研室,讲师
    • 1996/07-2003/07 第三军医大学,基础部人体解剖学教研室,助教

    二、主要研究方向 RESEARCH FILEDS

    1. 细胞多能性与组织再生研究
    2. 药物缓释及工程化改造的细胞治疗新技术开发
    3. 血管化复杂组织器官构建及新型医疗器械研发
    4. 仿生工程

    三、承担科研项目情况

    1. 81830055、心脏血管网络仿生构建的基础研究、国家自然科学基金重点项目、294万、2019-2023
    2. 2016YFC1101100     、基于血管化的复杂组织工程化构建、科技部国家重点研发计划、3750万(国拨1250万)、2016-2020
    3. 31625011  、组织工程学、国家杰出青年科学基金、400万、2017-2021
    4. 91439116、轴突再生在工程血管体内重构中的作用及分子机制、国家自然科学基金重大研究计划培育项目、100万、2015-2017
    5. 31470928、维持干细胞能量代谢稳态构建抗高糖损伤的工程血管、        国家自然科学基金、110万、2015-2018
    6. 31170935、腺苷及受体在构建工程血管中作用研究、国家自然科学基金、65万、2012-2015
    7. 2012AA020504、组织工程血管体内构建、科技部863项目子课题、      50万、    2012-2015
    8. BWS11C056、战创伤救治用新型生物人工血管及相关生物材料-生物人工血管研究课题、军队十二五重点课题、120万、2011-2015
    9. cstc2011jjjq0016、内皮祖细胞归巢于心血管植入物的分子机制        、重庆市杰出青年基金         、60万、2011-2014
    10. 2012B091000043、 自体内皮化的新型小口径生物人工血管及相关生物材料、省部产学研合作项目、136万、2012-2015
    11. 31028008、内皮祖细胞归巢于粥样硬化血管的分子机制          国家自然科学基金、海外合作项目(国内合作者)、20万、2011-2012

    四、代表性论文:*通讯作者 Selected Publications:*correspondence

    1. Feila Liu, Ning Ding, Da Huo, Guanyuan Yang, Keyu Wei, Ge Guan, Yanzhao Li, Jingyuan Yang, Tianran Wang, Yeqin Wang, Ju Tan, Wen Zeng*, Chuhong Zhu*. Surface-Engineered Monocyte Inhibits Atherosclerotic Plaque Destabilization via Graphene Quantum Dot-Mediated MicroRNA Delivery. Adv Healthc Mater. 2019 Aug;8(15):e1900386.      
    2. Ning Ding , Ce Dou , Yuxin Wang , Feila Liu , Ge Guan , Da Huo , Yanzhao Li , Jingyuan Yang , Keyu Wei , Mingcan Yang , Ju Tan , Wen Zeng*, Chuhong Zhu*. Antishear Stress Bionic Carbon Nanotube Mesh Coating with Intracellular Controlled Drug Delivery Constructing Small-Diameter Tissue-Engineered Vascular Grafts.Adv Healthc Mater. 2018 Jun;7(11):e1800026.
    3. Da Huo , Ge Liu , Yanzhao Li , Yuxin Wang , Ge Guan , Mingcan Yang , Keyu Wei , Jingyuan Yang , Lingqin Zeng , Gang Li , Wen Zeng*, Chuhong Zhu*. Construction of Antithrombotic Tissue-Engineered Blood Vessel via Reduced  Graphene Oxide Based Dual-Enzyme Biomimetic Cascade. ACS Nano. 2017, 11(11):10964-10973.                      
    4. Yanzhao Li, Simin Wan, Ge Liu, Wang Cai, Da Huo, Gang Li, Mingcan Yang, Yuxin Wang, Ge Guan, Ning Ding, Feila Liu, Wen Zeng*, Chuhong Zhu*. Netrin-1 Promotes Inflammation Resolution to Achieve Endothelialization of Small-diameter Tissue Engineering Blood Vessels by Improving Endothelial Progenitor Cells Function in Situ. Advanced Science. 2017;4(12):1700278                  
    5. Ge Liu, Li Li, Da Huo, Yanzhao Li, Yangxiao Wu, Lingqing Zeng, Panke Cheng, Malcolm Xing, Wen Zeng*, Chuhong Zhu*. A VEGF delivery system targeting MI improves angiogenesis and cardiac functionbased on the tropism of MSCs and layer-by-layer self-assembly. Biomaterials    ,2017;127:117-131.                       
    6. Panke Cheng, Wen Zeng, Li Li, Da Huo, Lingqing Zeng, Ju Tan, Jingting Zhou, Jiansen Sun, Ge Liu, Yanzhao Li, Ge Guan, Yuxin Wang, Chuhong Zhu*. PLGA-PNIPAM microspheres loaded with the gastrointestinal nutrient NaB ameliorate cardiac dysfunction by activating Sirt3 in acute myocardial infarction. Advanced Science. 2016;3(12):1600254.             
    7. Wen Chen, Wen Zeng, Jiansen Sun, Mingcan Yang, Li Li, Jingting Zhou, Yangxiao Wu, Jun Sun, Ge Liu, Rui Tang, Ju Tan, Chuhong Zhu*. Construction of an Aptamer-SiRNA Chimeras Modified Tissue- Engineered Blood Vessel for Cell Type-Specific Capture and Delivery.ACS Nano. 2015 Jun 23;9(6):6069-76.        
    8. Wen Chen, Fangjuan Wang, Wen Zeng, Jun Sun, Li Li, Mingcan Yang, Jiansen Sun, Yangxiao Wu, Xiaohui Zhao, Chuhong Zhu*. Regulation of Cellular Response Pattern to Phosphorus Ion is a New Target for the Design of Tissue-Engineered Blood Vessel. Adv Healthc Mater. 2015 May;4(7):1004-8
    9. Chunli Hou, Lei Shen, Qiang Huang, Jianhong Mi, Yangxiao Wu, Mingcan Yang, Wen Zeng, Li Li, Wen Chen, Chuhong Zhu*. The effect of heme oxygenase-1 complexed with collagen on MSC performance in the treatment of diabetic ischemic ulcer.  Biomaterials,34(1):112-20, 2013.     
    10. Wen Zeng, Can Wen, Yangxiao Wu, Li Li, Zhenhua Zhou, Jianhong Mi, Wen Chen, Mingcan Yang, Chunli Hou, Jiansen Sun, Chuhong Zhu*. The use of BDNF to enhance the patency rate of small-diameter tissue-engineered blood vessels through stem cell homing mechanisms. Biomaterials,33(2):473-84, 2012.       
    11. Wen Zeng, Wei Yuan, Li Li, Jianhong Mi, Shangcheng Xu, Can Wen, Zhenhua Zhou, Jiaqiang Xiong, Jiansen Sun, Dajun Ying, Mingcan Yang, Xiaosong Li, Chuhong Zhu*. The promotion of endothelial progenitor cells recruitment by nerve growth factors in tissue-engineered blood vessels, Biomaterials, 31(7):1636-45, 2010.      
    12. Wen Chen, Wen Zeng, Yangxiao Wu, Can Wen, Li Li, Ge Liu, Lei Shen, Mingcan Yang, Ju Tan, Chuhong Zhu*. The Construction of Tissue-Engineered Blood Vessels Crosslinked with Adenosine Loaded Chitosan/β-Cyclodextrin Nanoparticles using a Layer-by-Layer Assembly Method .Adv Healthc Mater. 3(11):1776-81,2014.  
    13. Weiyu Zhang, Jianguo Wang, Huan Wang, Rong Tang, John D Belcher, Benoit Viollet, Jian-Guo Geng, Chunxiang Zhang, Chaodong Wu, Arne Slungaard, Chuhong Zhu*, Yuqing Huo*. Acadesine inhibits tissue factor induction and thrombus formation by activating the phosphoinositide 3-kinase/Akt signaling pathway. Arterioscler Thromb Vasc Biol, 30(5):1000-6, 2010.

    五、获奖情况

    1. 重庆市优秀博士论文指导教师,2019
    2. 重庆市优秀学术论文指导教师,2018
    3. 全军优秀博士论文指导教师,2017
    4. 重庆市优秀博士论文指导教师,2015
    5. 重庆市教委研究生优质课程,2015
    6. 全国大学生基础医学创新论坛一等奖指导教师,2014
    7. 全军优秀硕士论文指导教师, 2011
    8. 军队院校育才银奖, 2010
    9. 军队科技进步二等奖, 2008

    六、专利

    1. 朱楚洪等,能在体实现自我重塑的生物人工血管,授权号:2015101993209, 2018
    2. 朱楚洪等,一种以脾脏细胞外基质为原料的水凝胶及其制备方法,授权号:2017103712374, 2019
    3. 朱楚洪等,一种新型多功能止血敷料,授权号:ZL2010101854701,2015
    4. 朱楚洪等,能在体捕获内皮祖细胞的生物人工血管,授权号:ZL 200710078482.2,2010
    5. 朱楚洪等,基因修饰的组织工程血管,授权号:ZL031357253,2006           
    6. 朱楚洪等,一种血管玻璃化保存液及保存方法,授权号:ZL03135727X,2008
    7. 朱楚洪等,一种体外血管培养反应装置,授权号:ZL032501706,2004
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