陈永昌（Yongchang Chen)

1996-2003年，甘肃农业大学，动物科学/动物遗传育种与繁殖，本科/硕士

2006-2010年，中国科学院昆明动物研究所，动物学，博士

2003-2014年，中国科学院昆明动物研究所，助研、副研究员

2014年-，昆明理工大学灵长类转化医学研究院，教授

2023年-，昆明理工大学生命科学与技术学院，教授，院长

1996-2003 Gansu Agricultural University, Bachelor's Degree/Master's Degree

2006-2010 Kunming Institute of Zoology, Chinese Academy of Sciences, Doctor’s Degree

2003-2014 Kunming Institute of Zoology, Chinese Academy of Sciences, Assistant and associate professor

2014-present Institute of Primate Translational Medicine, Kunming University of Science and Technology, Professor

2023-present, Dean and Professor, Faculty of Life Science and Technology, Kunming University of Science and Technology.

脑科学研究是生命及健康科学研究中最复杂、最重要、也是最具有吸引力的研究领域。因与人类在基因组相似度、脑结构及脑功能、生殖生理等方面具有高度的相似性，灵长类动物被认为是研究人类健康最理想的实验动物，也已被越来越多的研究结果所证实。利用灵长类动物模型开展脑发育及神经系统疾病的发病机理研究、探索有效的预防及治疗办法，是实现从基础研究到临床前研究，进而实现临床转化的重要桥梁。本研究团队多年来一直致力于神经系统疾病的灵长类动物模型构建、遗传学及行为学表型鉴定、发病机理及治疗策略的探索等方面的研究。现已构建了高效稳定的基因修饰灵长类动物模型研究平台、在世界上首次实现了对灵长类动物进行靶向基因修饰。目前已建立了多种神经系统疾病的灵长类动物模型，包括杜氏肌营养不良症（Duchenne Muscular Dystrophy，DMD）及瑞特综合征（Rett Syndrome，RTT）的基因编辑猴模型。相关研究结果发表在包括Cell、Cell Stem Cell、Cell Research、Human Molecular Genetics等杂志上。

Brain science is one of the most complex, important and attractive field in life and health science research. Primates are considered as the optimal experimental animals to study human health for its high similarity with human in genome, brain structure and function, and reproductive physiology. The use of NHP animal model to study brain development and neurological disease pathogenesis research, and to explore effective prevention and treatment methods, is the important bridge to deepen the brain science research from basic research to preclinical research, thus achieving clinical translation. Our research team has been working on the construction of primate models of neurological diseases, genetics and behavioral phenotypic identification, pathogenesis and therapeutic strategies for many years. A highly efficient and stable research platform of gene modified primate animal models has been established and the first targeted gene modification of primates in the world was achieved. The primate models of different neurological diseases were generated, including Parkinson's disease (PD), Amyotrophic Lateral Sclerosis (ALS), Duchenne Muscular Dystrophy (DMD) and Rett syndrome (RTT). The results of these studies were published in Cell (2014, 2017), Cell Stem Cell (2014, 2015), Cell Research (2015, 2017), Human Molecular Genetics (3 papers in 2015) and other magazines.

Our research interests include establishment of gene targeted monkey models of the nervous system disease, molecular mechanism of early developmental abnormalities and neurological diseases, genetic modification and cell therapy using genetically modified primate models, and primate reproductive biology.

1.云南省人社厅，云南省万人计划“云岭学者”，2020-2024，200万，主持

2.国家自然科学基金重点项目，81930121，基于猴模型的杜氏肌营养不良症（DMD）基因治疗临床前研究，2020-2024，297万，主持

3.云南省科技厅创新团队，202005AE160019，云南中科灵长类生物医学重点实验室神经疾病非人灵长类模型临床前研究省创新团队，100万，主持

4.科技创新2030-“脑科学与类脑研究”重大项目，2021ZD0200903，脑疾病模型猴制备与疾病早期诊断指标建立，参与

5.国家杰出青年科学基金，82125008，孤独症谱系障碍与非人灵长类模型，2022-2026，400万，主持

1. 获得云南省自然科学一等奖1项（2018，排名第三）
2. 入选2017年度“中国生命科学十大进展”
3. 中国实验动物学会优秀青年人才（2018）
4. 2021年获云南省自然科学奖一等奖（排名第四）
5. 2021年获全国专业技术人才先进集体

1. 陈永昌，牛昱宇，周引，卓艳，陈兴龙. 一种外埠实验用动物转移和实验笼. ZL201720614007.1. 2018.

2. 张波，陈永昌，周引，季维智，牛昱宇. 一种用于灵长类动物的行为测试笼. ZL201820543551.6. 2019.

3. 张波，周智刚，陈永昌，季维智. 一种用于灵长类动物眼动测试的非侵入式头部固定装置. ZL201721107312.8. 2019.

1. 云南省高校神经疾病灵长类动物模型的创建及转化研究科技创新团队（2019-2022），带头人
2. 云南中科灵长类生物医学重点实验室神经疾病非人灵长类模型临床前研究省创新团队（2019-2022），带头人

中国生物工程学会常务理事、中国研究型医院学会神经科学专业委员会副主委、《Animal Models and Experimental Medicine》及《中国比较医学杂志》副主编、《Zoological Research》编委。

1. Gong Y, Bai B, Sun N, Ci B, Shao H, ZhangT, Yao H, Zhang Y, Niu Y, Liu L, Zhao H, Wu H, Zhang L, Wang T, Li S, Wei Y, Yu Y, Ribeiro Orsi AE, Liu B, Ji W, Wu J, Chen Y, Tan T. Ex utero monkey embryogenesis from blastocyst to early organogenesis. Cell. 2023 May 11;186(10):2092-2110.e23.
2. Ren S, Huang M, Bai R, Chen L, Yang J,Zhang J, Guo W, Ji W, Chen Y. Efficient Modulation of Exon Skipping via Antisense Circular RNAs. Research (Wash D C). 2023;6:0045.
3. Wu R, Bai B, Li F, Bai R, Zhuo Y, Zhu Z,Jia R, Li S, Chen Y, Lan X. Phenotypes and genetic etiology of spontaneous polycystic kidney and liver disease in cynomolgus monkey. Front Vet Sci. 2023 Feb 16;10:1106016.
4. Liu Y, Shan L, Liu T, Li J, Chen Y,Sun C, Yang C, Bian X, Niu Y, Zhang C, Xi J, Rao Y. Molecular and cellular mechanisms of the first social relationship: A conserved role of 5-HT from mice to monkeys, upstream of oxytocin. Neuron. 2023 May 3;111(9):1468-1485.e7.
5. Lu S, Chen Y, Wang Z. Advances in the pathogenesis of Rett syndrome using cell models. Animal Model Exp Med. 2022Dec;5(6):532-541.
6. Xiao P, Bai R, Zhang T, Wu R, Chen L, HouY, Shen B, Niu Y, Li S, Ji W, Chen Y. Extensive humoral immune response to AAVs and Cas proteins in nonhuman primates. Sci Bull (Beijing). 2021 Oct 30;66(20):2061-2064.
7. Peng Li#，Yongchang Chen*. Progress in Modeling Neural Tube Development and Defects by Organoid Reconstruction. Neurosci. Bull. 2022.6. 2022 Jun 26. doi: 10.1007/s12264-022-00896-9. [IF: 5.271]
8. Huang M#，Li P#， Yang J#, Yongchang Chen*. Embryo-Engineered Nonhuman Primate Models: Progress and Gap to Translational Medicine.Research.2021 Aug 21
9. Wang J#, Wang Z#, Zhang H#, Feng S#, Lu Y#, Wang S, Wang H, Sun YE, Yongchang Chen*.White Matter Structural and Network Topological Changes Underlying the Behavioral Phenotype of MECP2 Mutant Monkeys.Cerebral Cortex.2021 Jun 12.[IF: 5.357]
10. Ran Yang, Alexander Goedel, Yu Kang, Chenyang Si, Chu Chu, Yi Zheng, Zhenzhen Chen, Peter J. Gruber, Yao Xiao, Chikai Zhou, Nevin Witman, Elif Eroglu, Chuen-Yan Leung, Yongchang Chen, Jianping Fu, Weizhi Ji*, Fredrik Lanner*, Yuyu Niu* & Kenneth R. Chien*.Amnion signals are essential for mesoderm formation in primates.Nature Communications.26 August 2021.12: 5126 (2021)
11. 周勤,王爽,张婷,李善刚,陈永昌*. 小鼠及猕猴胚胎MECP2基因T158M单碱基突变体系的建立 ^*[J]. 中国生物工程杂志, 2020, 40(6): 31-39.
12. Dong-Dong Qin , Shu-Fei Feng , Fei-Yu Zhang , Na Wang , Wen-Jie Sun , Yin Zhou , Teng-Fang Xiong , Xian-Lai Xu , Xiao-Ting Yang , Xiang Zhang , Xue Zhu , Xin-Tian Hu , Lei Xiong , Yun Liu , Yong-Chang Chen*. Potential use of actigraphy to measure sleep in monkeys: comparison with behavioral analysis from videography. Zool Res. 2020;41(4):437-443. doi:10.24272/j.issn.2095-8137.2020.056
13. Lei Shi†, Xin Luo, Jin Jiang, Yongchang Chen, Cirong Liu, TingHu, Min Li, Qiang Lin, Yanjiao Li, Jun Huang, Hong Wang，Yuyu Niu, Yundi Shi, Martin Styner, Jianhong Wang, Yi Lu, Xuejin Sun, Hualin Yu, Weizhi Ji*,Bing Su*. Natl Sci Rev. 2019 May; 6(3): 480-493.
14. Shuang Wang, Shuaiwei Ren, Raoxian Bai, Puhao Xiao, Qin Zhou, Yin Zhou, Zhigang Zhou, Yuyu Niu, Weizhi Ji, Yongchang Chen. No off-target mutations in functional genome regions of a CRISPR/Cas9-generated monkey model of muscular dystrophy. J Biol Chem.2018 Jul 27;293(30):11654-11658.
15. Shuang Wang, Lichuan Yang, Raoxian Bai, Shuaiwei Ren, Yuyu Niu, Yuanye Ma, Weizhi Ji, Yongchang Chen*. Interaction of p53 and ASPPs Regulates Rhesus Monkey Embryonic Stem Cells Conversion to Neural Fate Concomitant with Apoptosis. Cell Cycle. 2018;17(9):1146-1153.
16. Yiqiang Cui, Yuyu Niu, Jiankui Zhou, Yongchang Chen, Yiwei Cheng, Shangang Li, Zongyong Ai, Chu Chu, Hong Wang, Bo Zheng, Xuejin Chen, Jiahao Sha, Xuejiang Guo*, Xingxu Huang* Weizhi Ji*. Generation of a precise Oct4-hrGFP knockin Cynomolgus monkey model via CRISPR/Cas9-assisted homologous recombination. Cell Res. 2018 Jan; 28(3):383–386.
17. Yan Zhuo, Shuqing Feng, Shaoyong Huang, Xinglong Chen, Yu Kang, Chenyang Si, Zifan Li, Yin Zhou, Ling Zhou, Ting Zhang, Weizhi Ji, Yuyu Niu, Yongchang Chen. Transabdominal Ultrasound-guided Multifetal Pregnancy Reduction in 10 Cases of Monkeys.Biol Reprod. 2017 Nov 1;97(5):758-761.
18. Yongchang Chen, Juehua Yu, Yuyu Niu, Dongdong Qin, Hailiang Liu, Gang Li, Yingzhou Hu, Jiaojian Wang, Yi Lu, Yu Kang, Yong Jiang, Kunhua Wu, Siguang Li, Jingkuan Wei, Jing He, Junbang Wang, Xiaojing Liu, Yuping Luo, Chenyang Si, Raoxian Bai, Kunshan Zhang, Jie Liu, Shaoyong Huang, Zhenzhen Chen, Shuang Wang, Xiaoying Chen, Xinhua Bao, Qingping Zhang, Fuxing Li, Rui Geng, Aibin Liang, Dinggang Shen, Tianzi Jiang, Xintian Hu, Yuanye Ma, Weizhi Ji*, Yi Eve Sun*. Modeling Rett Syndrome using TALEN-edited MECP2 Mutant Monkeys. Cell. 2017 May 18;169 (5):945-955.e10.
19. Fei Gao, Yuyu Niu, Yi Eve Sun, Hanlin Lu, Yongchang Chen, Siguang Li, Yu Kang, Yuping Luo, Chenyang Si, Juehua Yu, Chang Li, Nianqin Sun, Wei Si, Hong Wang, Weizhi Ji* & Tao Tan *. De Novo DNA Methylation during Monkey Pre-implantation Embryogenesis. Cell Res. 2017 Apr;27(4):526-539.
20. Yongchang Chen, Yuyu Niu^*, Weizhi Ji^*. Genome Editing in Non-human Primates: Approach to GeneratingHuman Diseases Models. J Intern Med. 2016 Sep;280(3):246-51.
21. Yu Kang, Bo Zheng, Bin Shen, Yongchang Chen, Lei Wang, Jianying Wang, Yuyu Niu, Yiqiang Cui, Jiankui Zhou, Hong Wang, Xuejiang Guo, Bian Hu, Qi Zhou, Jiahao Sha*, Weizhi Ji*, Xingxu Huang*. CRISPR/Cas9-mediated Dax1 Knockout in the Monkey Recapitulates Human AHC-HH. Hum Mol Genet. 2015 Dec20;24(25):7255-64.
22. Yongchang Chen, Yuyu Niu, Yanjiao Li, Zongyong Ai, Yu Kang, Hong Shi, Zheng Xiang, Zhaohui Yang, Tao Tan, Wei Si, Wei Li, Xueshan Xia, Qi Zhou*, Weizhi Ji*, Tianqing Li* Generation of Cynomolgus Monkey Chimeric Fetuses Using Embryonic Stem Cells. Cell Stem Cell. 2015 Jul 2;17(1):116-24.
23. Yongchang Chen, Yinghui Zheng, Yu Kang, Weili Yang, Yuyu Niu, Xiangyu Guo, Zhuchi Tu, Chenyang Si, Hong Wang, Ruxiao Xing, Xiuqiong Pu, Shang-Hsun Yang, Shihua Li, Weizhi Ji*, Xiao-Jiang Li*. Functional Disruption of the Dystrophin Gene in Rhesus Monkey Using CRISPR/ Cas9. Hum Mol Genet. 2015; 24(13):3764-3774.
24. Yongchang Chen, Yiqiang Cui, Bin Shen, Yuyu Niu, Xiaoyang Zhao, Lei Wang, Jianying Wang, Wei Li, Qi Zhou, Weizhi Ji*, Jiahao Sha*, Xingxu Huang*. Germline Acquisition of Cas9/RNA-mediated Gene Modifications in Monkeys. Cell Res. 2015 Feb;25(2):262-5.
25. Yuyu Niu, Xiangyu Guo, Yongchang Chen, Chuan-En Wang, Jinquan Gao, Weili Yang, Yu Kang, Wei Si, Hong Wang, Shang-Hsun Yang, Shihua Li, Weizhi Ji*, Xiao-Jiang Li*. Early Parkinson's disease Symptoms in α-synuclein Transgenic Monkeys. Hum Mol Genet. 2015 Apr15;24(8):2308-17.
26. Hailiang Liu #, Yongchang Chen #, Yuyu Niu #, Kunshan Zhang #, Yu Kang, Weihong Ge, Xiaojing Liu, Enfeng Zhao, Chencheng Wang, Shaoyun Lin, Bo Jing, Chenyang Si, Quan Lin, Xiaoying Chen, Haijun Lin, Xiuqiong Pu, Yingying Wang, Binlian Qin, Fang Wang, Hong Wang, Wei Si, Jing Zhou, Tao Tan, Tianqing Li, Shaohui Ji, Zhigang Xue, Yuping Luo, Liming Cheng, Qi Zhou, Siguang Li*, Yi Eve Sun*, Weizhi Ji*. TALEN-mediated Gene Mutagenesis in Rhesus and Cynomolgus Monkeys. Cell Stem Cell. 2014 Mar 6; 14(3):323-8.
27. Yuyu Niu, Bin Shen, Yiqiang Cui, Yongchang Chen, Jianying Wang, Lei Wang, Yu Kang, Xiaoyang Zhao, Wei Si, Wei Li, Andy Peng Xiang, Jiankui Zhou, Xuejiang Guo, Ye Bi, Chenyang Si, Bian Hu, Guoying Dong, Hong Wang, Zuomin Zhou, Tianqing Li, Tao Tan, Xiuqiong Pu, Fang Wang, Shaohui Ji, Qi Zhou, Xingxu Huang*, Weizhi Ji*, Jiahao Sha*. Generation of Gene-modified Cynomolgus Monkey Via Cas9/RNA-mediated Gene Targeting in One-cell Embryos. Cell. 2014 Feb 13;156(4):836-43.
28. Huan Liu, Bo Zhao, Yongchang Chen, Dewen You, Rui Liu, Mingqiang Rong, Weizhi Ji, Ping Zheng, Ren LaiHuan Liu, Bo Zhao, Yongchang Chen, Dewen You, Rui Liu, Mingqiang Rong, Weizhi Ji*, Ping Zheng, Ren Lai*. Multiple Coagulation Factor Deficiency Protein 2 Contains the Ability to Support Stem Cell Self-renewal. FASEB J. 2013 Aug;27(8):3298-305.
29. Yongchang Chen, Yuyu Niu, Shihua Yang, Xiechao He, Shaohui Ji, Wei Si, Xianghui Tang, Yunhua Xie, Hong Wang, Yongqing Lu, Qi Zhou, Weizhi Ji*.The Available Time Window for Embryo Transfer in The Rhesus Monkey (Macaca mulatta). Am J Primatol. 2012 Feb;74(2):165-73.
30. Yongchang Chen, Zhengbo Wang, Yunhua Xie, Xiangyu Guo, Xianghui Tang, Shufen Wang, Shihua Yang, Kai Chen, Yuyu Niu, Weizhi Ji*. Folic Acid Deficiency Inhibits Neural Rosette Formation and Neuronal Differentiation from Rhesus MonkeyEmbryonic Stem Cells. J Neurosci Res. 2012Jul;90(7):1382-91.
31. Yongchang Chen, Yuyu Niu^*, Weizhi Ji^*. Transgenic Nonhuman Primate Models for Human Diseases: Approaches and Contributing Factors. J Genet Genomics. 2012 Jun20;39(6):247-51.

论文网 站 ( 动 态 更 新 )： https://www.researchgate.net/profile/Yongchang_Chen7

部分实验室成员合影

李媛媛（Yuanyuan Li），博士，讲师

E-mail：liyy@lpbr.cn

学习及工作经历 ( Education/Professional Experience )

2007-2011年，云南师范大学，生命科学学院，生物技术，理学学士

2011-2014年，东北师范大学，环境科学学院，环境科学，理学硕士

2015-2018年，中国科学院昆明动物研究所，遗传学，理学博士

2019-2020年，美国加州大学戴维斯分校，博士后

2020年-，昆明理工大学灵长类转化医学院，讲师

2007-2011 Yunnan Normal University, College of Life Science, Biotechnology, Bachelor's Degree

2011-2014 Northeast Normal University, College of Environmental Science, Environmental Science, Master's Degree

2015-2018 Kunming Institute of Zoology, Chinese Academy of Sciences, Genetics, Doctor’s Degree

2019-2020 University of California, Davis, Postdoc

2020-present Institute of Primate Translational Medicine, Kunming University of Science and Technology, Lecturer

主要研究方向 (Research Interest)

基于脑胚胎发育研究灵长类神经性疾病的致病机理

The pathogenesis of neuropathic diseases based on the embryonic development of brain in primates

主持并正在执行的科研项目（Research Projects）

1.国家自然科学基金重大研究计划 (#9173130038)，2018.01-2019.12 主要参与人

2. 国家自然科学基金重点项目(#31930011)，2020.01-2024.12 主要参与人

3.云南省科技厅, 基础研究专项-面上项目, 202401AT070313, Rett综合征模型猴大脑海马单细胞双组学图谱绘制及机制研究, 2024.03-2027.02 在研, 主持

代表性论文（Selected publications）

1. Li YY^＃, Liu Z^＃, Qi FY, Zhou X, Shi P*. Functional Effects of a Retained ancestral polymorphism in prestin. Molecular biology and evolution, 2017,34(1): 88–92.

2. Li YY, Wang J, Metzner W*, Luo B, Jiang T, Yang S, Shi L, Huang X, Yue X, Feng J*. Behavioral responses to echolocation calls from sympatric heterospecific bats: implications for interspecific competition. Behavioral ecology and sociobiology, 2014, 68(4): 657-667.

3. Luo B, Huang X, Li YY, Lu G, Zhao J, Zhang K, Zhao H, Liu Y, Feng J*.Social call divergence in bats: a comparative analysis. Behavioral Ecology, 2017, 28(2): 533-540.

4. Liu Z^＃, Chen P^＃, Li YY^＃, Li MW, Liu Q, Pan WL, & Shi P*. Cochlear hair cells of echolocating bats are immune to intense noise. Journal of Genetics and Genomics, 2021, 48(11), 984-993.

5. Shan S, He J, Sun Q, Zhu K, Li YY, Reid B, ... & Zhao M.* Dynamics of cutaneous atmospheric oxygen uptake in response to mechanical stretch revealed by optical fiber microsensor. Experimental Dermatology, 2023,32(12), 2112-2120.

6. Sun H, Cui H, Sun Q, Li YY, Bai T, Wang K, ... & Wang J. Individual large-scale functional network mapping for major depressive disorder with electroconvulsive therapy. Journal of Affective Disorders. 2024.

郭文婷（Wenting Guo），博士后，助理研究员

E-mail：guowt@lpbr.cn

学习及工作经历（Education/ Professional Experience）

2006-2011年，哈尔滨医科大学，药学（临床药学方向），学士

2011-2014年，哈尔滨医科大学，药理学，硕士

2014-2021年，加拿大卡尔加里大学 (University of Calgary)，心血管与呼吸科学 (Cardiovascular and Respiratory Sciences)，博士

2022年-，昆明理工大学，灵长类转化医学研究院，博士后，助理研究员

2006-2011 Harbin Medical University, Clinical Pharmacy, Bachelor's Degree

2011-2014 Harbin Medical University, Pharmacology, Master's Degree

2014-2021 University of Calgary, Cardiovascular and Respiratory Sciences, Doctor’s Degree

2022-present Institute of Primate Translational Medicine, Kunming University of Science and Technology, Postdoctoral Fellow, Assist Professor

主要研究方向 (Research Interest)

细胞多能性，神经肌肉疾病机制及治疗

Cellular pluripotency and mechanism and treatment of neuromuscular disease

承担科研项目情况（Research Projects）

1.国家自然科学基金青年项目，82301348，Rett综合征Ca²⁺稳态失衡导致心脏功能异常的分子机制研究，2024/01-2026/12，30万元，在研，主持

2.国家自然科学基金面上项目，82373872，浦肯野纤维IP3R1功能亢进导致室性心律失常的分子机制研究，2024/01-2027/12，49万元，在研，参与

代表论文（Selected Publications）

1. Wenting Guo, Jinhong Wei, John Paul Estillore, Lin Zhang, Ruiwu Wang, Bo Sun, and S. R. Wayne Chen. "RyR2 disease mutations at the C-terminal domain intersubunit interface alter closed-state stability and channel activation" Journal of Biological Chemistry, 2021 Jul;297(1):100808.

2. Wenting Guo, Bo Sun, John Paul Estillore, Ruiwu Wang, and SR Wayne Chen. "The central domain of cardiac ryanodine receptor governs channel activation, regulation, and stability." Journal of Biological Chemistry, 295, 46 (2020): 15622-15635.

3. Wenting Guo, Bo Sun, Zhichao Xiao, Yingjie Liu, Yundi Wang, Lin Zhang, Ruiwu Wang, and SR Wayne Chen. "The EF-hand Ca2+ binding domain is not required for cytosolic Ca²⁺ activation of the cardiac ryanodine receptor." Journal of Biological Chemistry, 291, 5 (2016): 2150-2160.

4. Jinhong Wei, Wenting Guo, Ruiwu Wang, John Paul Estillore, Darrell Belke, Yong-Xiang Chen 1, Alexander Vallmitjana 2, Raul Benitez 3, Leif Hove-Madsen 4, S R Wayne Chen. RyR2 Serine-2030 PKA Site Governs Ca²⁺ Release Termination and Ca²⁺ Alternans. Circ Res. 2023 Jan 20;132(2):e59-e77.

5. Wei Peng, Huaizong Shen, Jianping Wu, Wenting Guo, Xiaojing Pan, Ruiwu Wang, SR Wayne Chen, and Nieng Yan. "Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2." Science 354, 6310 (2016).

6. Wenting Guo, and Deli Dong. "Bone morphogenetic protein-4: a novel therapeutic target for pathological cardiac hypertrophy/heart failure." Heart failure reviews, 19, 6 (2014): 781-788.

7. Xiaowei Zhong, Wenting Guo, Jinhong Wei, Yijun Tang, Yingjie Liu, Joe Z Zhang, Vern Hsen Tan, Lin Zhang, Ruiwu Wang, Peter P Jones, Carlo Napolitano, Silvia G Priori, S.R. Wayne Chen. Identification of loss-of-function RyR2 mutations associated with idiopathic ventricular fibrillation and sudden death. Biosci Rep. 2021 Apr 30;41(4):BSR20210209.

8. Sun, Bo, Wenting Guo, Xixi Tian, Jinjing Yao, Lin Zhang, Ruiwu Wang, and SR Wayne Chen. "The cytoplasmic region of inner helix S6 is an important determinant of cardiac ryanodine receptor channel gating." Journal of Biological Chemistry, 291, 50 (2016): 26024-26034.

9. Xiao Z, Wenting Guo, Sun B, Hunt DJ, Wei J, Liu Y, Wang Y, Wang R, Jones PP, Back TG, Chen SW. Enhanced Cytosolic Ca2+ Activation Underlies a Common Defect of Central Domain Cardiac Ryanodine Receptor Mutations Linked to Arrhythmias. Journal of Biological Chemistry, 291.47 (2016): 24528-24537.

10. Jones, Peter P., Wenting Guo, and SR Wayne Chen. "Control of cardiac ryanodine receptor by sarcoplasmic reticulum luminal Ca2+." Journal of General Physiology 149, 9 (2017): 867-875.

11. Zhong, Xiaowei, Wenting Guo, Jinhong Wei, Yijun Tang, Yingjie Liu, Joe Z. Zhang, Vern Hsen Tan et al. "Identification of loss-of-function RyR2 mutations associated with idiopathic ventricular fibrillation and sudden death." Bioscience Reports 41, no. 4 (2021): BSR20210209.

12. Roston TM, Wenting Guo, Krahn AD, Wang R, Van Petegem F, Sanatani S, Chen SW, Lehman A. A novel RYR2 loss-of-function mutation (I4855M) is associated with left ventricular non-compaction and atypical catecholaminergic polymorphic ventricular tachycardia." Journal of electrocardiology 50.2 (2017): 227-233.

张婷（Ting Zhang），博士生，助理研究员

E-mail：zhangt@lpbr.cn

学习及工作经历 ( Education and Research Experience )

2010–2014年, 云南中医学院，制药工程，学士学位；

2014–2017年, 云南中医学院，药物分析，硕士学位；

2020-，昆明理工大学，生物学，博士在读

2010–2014, Yunnan University of Traditional Chinese Medicine, Pharmaceutical Engineering, Bachelor's Degree

2014–2017, Yunnan University of Traditional Chinese Medicine, Pharmaceutical Analysis, Master’s Degree

2020-present, Kunming University of Science and Technology, Biology, PhD candidate

主要研究方向（Research Interest）

胚胎早期发育与神经发育疾病

Early embryonic development and neurodevelopmental diseases

承担科研项目情况（Research Projects）

1.云南省基础研究计划项目青年项目，201801YH00005，Rett综合征食蟹猴模型肠道菌群变化的研究，2019.10-2022.10，5万，结题，主持

2.科技创新2030-“脑科学与类脑研究”重大项目，2021ZD0200903，脑疾病模型猴制备与疾病早期诊断指标建立，2021.12-2026.11，1056.74万，在研，参与

3.云南省科技厅创新团队，202005AE160019，云南中科灵长类生物医学重点实验室神经疾病非人灵长类模型临床前研究省创新团队，2020.01-2022.12，100万，结题，参与

4.云南省教育厅创新团队，云南省高校神经疾病灵长类动物模型的创建及转化研究科技创新团队，2019.01-2022.01，60万，结题，参与

5.国家重点研发计划课题，2018YFA0107902，利用动物模型在体示踪干细胞，2018.07-2022.12，771万，结题，参与

代表论文（Selected Publications）

1. Yandong Gong^#, Bing Bai^#, Nianqin Sun^#, Baiquan Ci^#, Honglian Shao^#, Ting Zhang^#, Hui Yao, Youyue Zhang, Yuyu Niu, Lizhong Liu, Hu Zhao, Hao Wu, Lei Zhang, Tianxiang Wang, Shangang Li, Yulei Wei, Yang Yu, Ana Elisa Ribeiro Orsi, Bing Liu, Weizhi Ji, Jun Wu, Yongchang Chen, Tao Tan, Ex utero monkey embryogenesis from blastocyst to early organogenesis, Cell, 2023. 186(10):2092-2110.

2. Ting Zhang^#, Yu Kang, Yin Zhou, Xinglong Chen, Yan Zhuo, Zifan Li, Hong Wang, Shangang Li, Yongchang Chen*, Interspecies embryo transfer between rhesus and cynomolgus monkeys, Journal of Genetics and Genomics, 2020. 47:333-336.

3. Fengjiao Li, Ting Zhang, Yanran He, Wen Gu, Xingxin Yang, Ronghua Zhao, Jie Yu*，Inflammation inhibition and gut microbiota regulation by TSG to combat atherosclerosis in ApoE−/− mice, Journal of Ethnopharmacology, 2020.1,30:112232-112242.

4. Ting Zhang^#, Shanhong Lu, Qian Bi, Li Liang, Yanfang Wang, Xingxin Yang, Wen Gu*, Jie Yu*, Volatile Oil from Amomi Fructus Attenuates 5-Fluorouracil-Induced Intestinal Mucositis, Frontiers in Pharmacology, 2017.11, 8:786-799.

5. Yan Zhuo^#, Shuqing Feng^#, Shaoyong Huang^#, Xinglong Chen, Yu Kang Chenyang Si, Zifan Li, Yin Zhou, Ling Zhou, Ting Zhang, Weizhi Ji, Yuyu Niu* Yongchang Chen*, Transabdominal ultrasound-guided multifetal pregnancy reduction in 10 cases of monkeys, Biology of Reproduction, 2017.11, 97(5): 758-761.

6. Mingnuan Han, Ting Zhang, Wen Gu, Xingxin Yang, Ronghua Zhao*, Jie Yu*. 2,3,5,4’-tetrahydroxy-stilbene-2-O-β-D-glucoside attenuates methionine and choline-deficient diet-induced non-alcoholic fatty liver disease. Experimental and Therapeutic Medicine. 2018,16:1087-1094.

7. Zhu Chen, Wanye Ni, Caixia Yang, Ting Zhang, Shanhong Lu, Ronghua Zhao, Xiaojian Mao* and Jie Yu*.Therapeutic Effect of Amomum villosum on Inflammatory Bowel Disease in Rats. Frontiers in Pharmacology. 2018, 9:639-654.

8. Xing-Xin Yang, Wen Gu,a Li Liang, Hong-Li Yan, Yan-Fang Wang, Qian Bi, Ting Zhang, Jie Yu* and Gao-Xiong Rao*. Screening for the bioactive constituents oftraditional chinese medicines-progress and challenges. RSC Advances. 2017, 7:3098-3100.

卓艳（Yan Zhuo），硕士生，实验室秘书

E-mail：zhuoy@lpbr.cn

刘杰（Jie Liu），助理研究员

E-mail：liuj@lpbr.cn

已毕业博士：任帅伟、王爽、白绕仙、吴若

已毕业硕士：陈浪（联合培养）、黄少勇、周勤、冯书斐、蔡润泽、殷文权、陆思佳、赵治鹏、黄媚、杨娇、赖跃昭

在读博士生：张臻、侯宇、马跃、李鹏、肖浦豪、张俊雨、孙文杰、周佳伟

在读硕士生：刘小平、王小鹏、李镝、肖钰欣、刘思雨、周超燃、王浩蓉、卢瑾昱、付育、黄译仪、季允、田贝贝

博士后：杨峻峰（在职）、张波（已出站）、秦冬冬（已出站）

本团队常年招收副研究员、博士生、硕士生、博士后和外国留学生，欢迎联系chenyc@lpbr.cn。