魏景宽 (Jingkuan Wei)

1. 2015年9月－现在，昆明理工大学 灵长类转化医学研究院，讲师/教授
2. 2008年9月－2015年7月，中科院昆明动物研究所，神经生物学，理学博士
3. 2003年9月－2007年7月，河北农业大学/生命学院，生物技术，理学学士

神经系统疾病与衰老引发的大脑结构病变及功能衰退被认为是生物个体认知与运动障碍的根源。为破解这一难题，神经与行为课题组通过建立高度模拟临床病理进展的疾病与衰老模型，基于透射电镜和超分辨成像技术，结合电生理、行为学及分子多组学等多维技术体系，解析神经环路异常与认知改变的关键机制。在此基础上，探索细胞治疗和神经调控等先进治疗策略的新方法与新技术。我们课题组当前重点聚焦的重大神经系统疾病包括：帕金森病（PD）、肌萎缩侧索硬化症（ALS）以及癫痫等。主要研究方向包括：

• 解析复杂发育和退行性神经疾病（PD、ALS、癫痫)的致病机理
• 利用灵长类动物模型探索细胞治疗及神经调控干预复杂神经疾病的新方法和新技术

Neurological diseases and aging drive structural and functional brain deterioration. Utilizing highly physiologically relevant in vivo and in vitro models, our research group leverages a comprehensive suite of technologies, including TEM, super-resolution imaging, electrophysiology, behavioral testing, and multi-omics, to decipher the underlying mechanisms driving neural circuit abnormalities and cognitive impairment. Ultimately, we seek to translate these findings into advanced biological treatments, actively exploring cutting-edge approaches such as cell therapy and neuromodulation. Our current research predominantly focuses on major neurological conditions: Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and epilepsy.

• To systematically elucidate the molecular and cellular pathogenesis underlying complex neurodevelopmental and neurodegenerative disorders, including PD, ALS, and epilepsy.
• To leverage NHP models to explore and develop innovative strategies and approaches, specifically cell-based therapies and neuromodulation for the intervention of complex neurological diseases.

• 云南省基础研究重点项目（202301AS070115），50万元，2024/03-2027/02，主持。
• 国家自然科学基金（32260197），2023/1-2026/12，34万元，主持。
• 云南省“兴滇英才”青年人才（YNWR-QNBJ-2020-133）项目支持，2021/09-2025/12，50万元，主持，结题。
• 国家重点研发计划课题子课题（2018YFA0108503），2018/07-2022/12，210万元，主持，结题。

• Ning Bian, Jianing Shen, Linwei Tian, Jinghui Li, Lu Yang, Bo Yuan, Shulin Li, Yuyu Niu, Lu Zhao, Jingkuan Wei. Astrocytic mitochondria transplantation rescues neuron loss and dendritic injuries in acute cerebral ischemic stroke mouse model by flexibly regulating mitochondria dynamics. Annals of Neurology. 2026 Feb 19, 11(2):78197. DOI: 10.1002/ana.78197.
• Renli Qi, Jun Wang, Honglong Pei, Mou Zhang, Jianing Shen, Xuanhe Chen, Yanmei Chen, Hualin Yu, Jinghui Li, Jingkuan Wei. Vagus Nerve Stimulation Enhances Memory and Long-term Potentiation via the Hippocampal NE/β-AR Signaling Pathway in Pilocarpine Rats. Brain Research Bulletin. 2026 Feb, 41(2):23875.
• Jianing Shen, Yong Li, Ning Bian, Lu Yang, Yangping Pan, Yuyu Niu, Lu Zhao, Lei Zhang and Jingkuan Wei Photocuring CsA and bFGF-embedded hemostatic hydrogel promotes recovery from TBI by mitigating ferroptosis and neuroinflammation. iScience. 2025 Jun 9; 28(7):112865. doi: 10.1016/j.isci.2025.11286
• Jianing Shen, Ning Bian, Lu Zhao, Jingkuan Wei. The role of T-lymphocytes in central nervous system diseases. Brain Research Bulletin. 2024 Feb 20; 209:110904.
• Lizhu Xu, Dan Wang, Lu Zhao, Zhengsheng Yang, Xu Liu, Xinyue Li, Tingli Yuan, Ye Wang, Tianzhuang Huang, Ning Bian, Yuqun He, Xinglong Chen, Baohong Tian, Zexian Liu, Fucheng Luo, Wei Si, Guangping Gao, Weizhi Ji, Yuyu Niu, Jingkuan Wei. C9orf72 poly-(PR) aggregation in nucleus induces ALS/FTD-related neurodegeneration in cynomolgus monkeys. Neurobiology of Disease. 2023 Aug; 184:106197.
• Xue Gan, Jiahan Ren, Tianzhuang Huang, Kunhua Wu, Shulin Li, Yanchao Duan, Zhengbo Wang, Wei Si, Jingkuan Wei. Pathological α-synuclein accumulation, CSF metabolites changes and brain microstructures in cynomolgus monkeys treated with 6-hydroxydopamine. Neurotoxicology. 2023 Jan; 94: 172-181.
• Renli Qi, Minshu Wang, Qian Zhong, Lanlin Wang, Xinwang Yang, Baihui Huang, Zhengsheng Yang, Cong Zhang, Xin Geng, Cheng Luo, Wei Wang, Jinghui Li, Hualin Yu, Jingkuan Wei. Chronic vagus nerve stimulation (VNS) altered IL-6, IL-1β, CXCL-1 and IL-13 levels in the hippocampus of rats with LiCl-pilocarpine-induced epilepsy. Brain Research. 2022 Apr 1;1780 (147800).
• Yanmei Chen, Yiling Ni, Jianhong Zhou, Hua Zhou, Qian Zhong, Xinyue Li, Jichuan Zhang, Yuanye Ma, Jingkuan Wei. The Amygdala Responds Rapidly to Flashes Linked to Direct Retinal Innervation: A Flash-evoked Potential Study Across Cortical and Subcortical Visual Pathways. Neuroscience. Bulletin. 2021 Aug;37(8):1107-1118.
• Cheng Xiang, Zhi-Na Li, Tian-Zhuang Huang, Jing-hui Li, Lei Yang, Jing-Kuan Wei. Threshold for maximal electroshock seizures (MEST) at three developmental stages in young mice. Zoological Research. 2019 May 18;40(3)
• Jingkuan Wei, Shulin Li, Dingna Duan, Kunhua Wu, Xu Liu, Ran Zhu, Li Wang, Zhengwang Wu, Yu Kang, Chenyang Si, Hongjiang Zhang, Hong Wang, Yongchang Chen, Shaoxing Dai, Weizhi Ji, Gang Li, Lu Zhao, Yuyu Niu. The α-synuclein aggregation and brain atrophy in SNCA-A53T transgenic monkeys correlate with parkinsonism. Brain. 2026 Feb 7:awag046. doi: 10.1093/brain/awag046
• Jingkuan Wei, Shaoxing Dai, Yaping Yan, Shulin Li, Pengpeng Yang, Ran Zhu, Tianzhuang Huang, Xi Li, Yanchao Duan, Zhengbo Wang, Weizhi Ji, Wei Si. Spatiotemporal proteomic atlas of multiple brain regions across early fetal to neonatal stages in cynomolgus monkey. Nature Communications. 2023 Jul 3; 14(1): 3917.
• Jing-Kuan Wei, Wen-Chao Wang, Rong-Wei Zhai, YH Zhang, SC Yang, Joshua R, L Li, LQ Xu; L Liu, MK Pan, YZ Hu, Abdelaziz G, J Wu, LC Yang, H Li, LB Lv, JL Li, YG Yao, L Xu, XL Feng, Y Yin, DD Qin, Xin-Tian Hu, Zheng-Bo Wang. Neurons Differentiated from Transplanted Stem Cells Respond Functionally to Acoustic Stimuli in the Awake Monkey Brain. Cell Reports, 2016, 16(4): 1016-1025.

欢迎优秀的本科生和硕士报考实验室的硕士和博士研究生。要求获得本科及以上学历，具有独立研究工作能力和合作精神，善于交流，有良好的文字表达能力和协调沟通能力。

有意者请发送简历至weijk@lpbr.cn。