研究员，博士生导师

解放军总医院第五医学中心

血液病医学部，血液学研究所所长

昆明理工大学特聘教授

一、工作经历

• 1996-1999年：第二军医大学，免疫学专业，医学博士；
• 2002-2004年：军事医学科学院基础医学研究所，助理研究员；
• 2004-2010年：军事医学科学院附属医院，副研究员；
• 2010-2018年：军事医学科学院附属医院，研究员；
• 2018年至今： 解放军总医院第五医学中心，研究员。

二、承担科研项目情况

• 国家重点研发计划项目，2017YFA0103400，“中胚层来源组织干细胞的谱系层级、发育调控及制备策略”（2017-2021）。
• 国家自然科学基金重点项目，31930054，“人胚生血结构及功能的单细胞尺度解析”（2020-2024）。
• 国家杰出青年科学基金项目，31930054，“造血调控”（2015-2019）。

三、获奖情况

• 国家自然科学二等奖（第二完成人）（2020）
• 干细胞研究创新奖（2016）

四、代表性论文

1. He Jian^#, Yan Jing^#, Wang Jianfang^#, Zhao Liangyu^#, Xin Qian^#, Zeng Yang, Sun, Yuxi Zhang, Han, Bai Zhijie, Li Zongcheng, Ni Yanli, Gong Yandong, Li Yunqiao, He Han, Bian Zhilei, Lan Yu, Ma Chunyu, Bian Lihong, Zhu Heng*, Liu Bing*, Yue Rui*. Dissecting human embryonic skeletal stem cell ontogeny by single-cell transcriptomic and functional analyses. Cell Research (2021).
2. Hongtao Wang, Jian He, Changlu Xu, Xiaoyuan Chen, Hua Yang, Shujuan Shi, Cuicui Liu, Yang Zeng, Dan Wu, Zhijie Bai, Mengge Wang, Yuqi Wen, Pei Su, Meijuan Xia, Baiming Huang, Chunyu Ma, Lihong Bian, Yu Lan, Tao Cheng, Lihong Shi*, Bing Liu*, Jiaxi Zhou*. Decoding human megakaryocyte development. Cell Stem Cell, 28, 535-549.e8 (2021).
3. Zhilei Bian^#, Yandong Gong^#, Tao Huang^#, Christopher Z. W. Lee^#, Lihong Bian^#, Zhijie Bai^#, Hui Shi^#, Yang Zeng, Chen Liu, Jian He, Jie Zhou, Xianlong Li, Zongcheng Li, Yanli Ni, Chunyu Ma, Lei Cui, Rui Zhang, Jerry K. Y. Chan, Lai Guan Ng, Yu Lan*, Florent Ginhoux* & Bing Liu*, Deciphering human macrophage development at single-cell resolution. Nature, 582, 571–576 (2020).
4. Siyuan Hou, Zongcheng Li, Xiaona Zheng, Yun Gao, Ji Dong, Yanli Ni, Xiaobo Wang, Yunqiao Li, Xiaochen Ding, Zhilin Chang, Shuaili Li, Yuqiong Hu, Xiaoying Fan, Yu Hou, Lu Wen, Bing Liu*, Fuchou Tang*, Yu Lan*. Embryonic endothelial evolution towards first hematopoietic stem cells revealed by single-cell transcriptomic and functional analyses. Cell Research, 30, 376-392(2020).
5. Min Zhang^#, Hui Yang^#, Lingfei Wan^#, Zhaohai Wang, Haiyang Wang, Chen Ge, Yunhui Liu, Yajing Hao, Dongdong Zhang, Gaona Shi, Yandong Gong, Yanli Ni, Chaojie Wang, Yuan Zhang, Jiafei Xi, Sen Wang, Lei Shi, Lina Zhang, Wen Yue*, Xuetao Pei*, Bing Liu*, Xinlong Yan*, Single-cell transcriptomic architecture and intercellular crosstalk of human intrahepatic cholangiocarcinoma. Journal of Hepatology, 73, 1118-1130(2020).
6. Min Zhang^#, Shuofeng Hu^#, Min Min^#, Yanli Ni, Zheng Lu, Xiaotian Sun, Jiaqi Wu, Bing Liu*, Xiaomin Ying*, Yan Liu*. Dissecting transcriptional heterogeneity in primary gastric adenocarcinoma by single cell RNA sequencing. Gut, 20, 30360-3(2020).
7. Yang Zeng^#, Chen Liu^#, Yangdong Gong^#, Zhijie Bai^#, Siyuan Hou^#, Jian He, Zhilei Bian, Zongcheng Li, Yanli Ni, Jing Yan, Tao Huang, Hui Shi, Chunyu Ma, Xueying Chen, Jinyong Wang, Lihong Bian, Yu Lan*, Bing Liu*, Hongbo Hu*. Single-Cell RNA Sequencing Resolves Spatiotemporal Development of Pre-thymic Lymphoid Progenitors and Thymus Organogenesis in Human Embryos. Immunity. 2019, 51, 930–948.
8. Yang Zeng^#, Jian He^#,, Zhijie Bai^#,, Zongcheng Li^#,, Yangdong Gong, Chen Liu, Junjie Du, Chunyu Ma, Lihong Bian, Yu Lan*, Bing Liu*. Tracing the first hematopoietic stem cell generation in human embryo by single-cell RNA sequencing. Cell Research. 2019, 29: 881-894.
9. Xiaona zheng^#,Guangyu Zhang, Yandong Gong, Xiaowei Ning, Zhijie Bai, Jian He, Fan Zhou, Yanli Ni, Yu Lan, Bing Liu*. Embryonic lineage tracing with Procr-CreER marks balanced hematopoietic stem cell fate during entire mouse lifespan. J Genet Genomics. 2019 Oct 20;46(10):489-498.
10. Jie Zhou^#, Jiayue Xu^#, Linlin Zhang^#, Siqi Liu^#, Yanni Ma^#, Xin Wen, Junkai Hao, Zongcheng Li, Yanli Ni, Xianlong Li, Fan Zhou, Qingqing Li, Fang Wang, Xiaoshuang Wang, Yanmin Si, Pengcheng Zhang, Chen Liu, Marisa Bartolomei, Fuchou Tang, Bing Liu*, Jia Yu*, Yu Lan*. Combined Single-Cell Profiling of lncRNAs and Functional Screening Reveals that H19 Is Pivotal for Embryonic Hematopoietic Stem Cell Development. Cell Stem Cell. 2019, 24: 285-298.
11. Hui Ye^#, Xiaobo Wang^#, Zongcheng LI, Fan Zhou, Xianlong Li, Yanli Ni, Weijing  Zhang, Fuchou Tang, Bing Liu*, Yu Lan*. Clonal analysis reveals remarkable functional heterogeneity during hematopoietic stem cell emergence. Cell Research. 2017, 27:1065-1068.
12. Fan Zhou^#, Xianlong Li^#, Weili Wang^#, Ping Zhu^#, Jie Zhou^#, Wenyan He^#, Meng Ding, Fuyin Xiong, Xiaona Zheng, Zhuan Li, Yanli Ni, Xiaohuan Mu, Lu Wen, Tao Cheng, Yu Lan, Weiping Yuan*, Fuchou Tang*, Bing Liu*. Tracing haematopoietic stem cell formation at single-cell resolution. Nature. 2016, 533: 487-492.
13. Yunze Zhao^#, Jie Zhou, Dan Liu, Fang Dong, Hui Cheng, Weili Wang, Yakun Pang, Yajie Wang, Xiaohuan Mu, Yanli Ni, Zhuan Li, Huiyu Xu, Sha Hao, Xiaochen Wang, Shihui Ma, Qianfei Wang, Guozhi Xiao, Weiping Yuan, Bing Liu*, Tao Cheng*. ATF4 plays a pivotal role in the development of functional hematopoietic stem cells in mouse fetal liver. Blood.2015, 126(21):2383-2391.
14. Zhuan Li^#, Yu Lan^#, Wenyan He, Dongbo Chen, Jun Wang, Fan Zhou, Yu Wang, Huayan Sun, Xianda Chen, Chunhong Xu, Sha Li, Yakun Pang, Guangzhou Zhang, Liping Yang, Lingling Zhu, Ming Fan, Aijia Shang, Zhenyu Ju, Lingfei Luo, Yuqiang Ding, Wei Guo, Weiping Yuan, Xiao Yang*, Bing Liu*. Mouse Embryonic Head as a Site for Hematopoietic Stem Cell Development. Cell Stem Cell. 2012, 11(5): 663-675.