罗富成（Fucheng Luo）

E-mail： luofc@lpbr.cn

一、教育背景及工作经历 ( Education and Work Experience )

• 2020.1-至今：昆明理工大学 灵长类转化医学研究院，教授
• 2018.5－2019.12：美国 辛辛那提大学 医学院，博士后
• 2012.10－2018.4：美国 凯斯西储大学 医学院，博士后
• 2007.9－2012.9：昆明理工大学 环境科学与工程学院，博士
• 2003.9－2007.8：昆明理工大学 生命科学与技术学院，学士

二、主要研究方向 (Research Interest)

1. 胚胎神经发育机制研究

2. 髓鞘发育与再生机制研究

3. 脑衰老机制及调控研究

三、科研领域描述 (Description ofScientific Research)

大脑是人体中发育最早、成熟最晚、最为完善的器官，至今仍存在许多未解之谜。大脑如何从无到有并发育成熟？如何延缓脑老化与防止脑疾病的发生？如何促进神经再生？这些问题一直是脑科学研究中的重要问题。针对这些科学问题，我们以胚胎干细胞、基因修饰小鼠、灵长类动物（恒河猴与食蟹猴）以及人脑类器官作为研究模型，综合运用分子生物学、电生理学、行为学、单细胞多组学技术、透射电镜、核磁共振成像等技术手段，开展脑科学研究。

四、承担科研项目（Research Funding）

1. 国家自然科学基金-面上项目（#82371578），2024-01-2027-12，在研，主持

2.国家自然科学基金-地区科学基金项目(#82060234)， 2021-01到2024-12，在研，主持

五、代表性论文（Selected Publications）

1. Zhang R*, Quan H, Wang Y, LuoF*. Neurogenesis in primates versus rodents and the value of non-humanprimate models. Natl Sci Rev. 2023 Sep15;10(11):nwad248.
2. Fucheng Luo, Jiapeng Wang, Zhen Zhang, Zhen You, Alicia Bedolla, FearGod Okwubido-Williams, L. Frank Huang, Jerry Silver, Yu Luo*. Inhibition of chondroitin sulfate proteoglycan receptor PTPσ promotes the migration of newly born neuroblasts, axonal sprouting and recovery from stroke. Cell Reports. 2022. 40(4):111137.
3. Fucheng Luo, Zhen Zhang and Yu Luo*. Differential Role of p53 in Oligodendrocyte Survival in Response to Various Stresses: Experimental Autoimmune Encephalomyelitis, Cuprizone Intoxication or White Matter Stroke. Int. J. Mol. Sci. 2021, 22, 12811. https://doi.org/10.3390/ijms222312811
4. Fucheng Luo, Zhen Zhang, Austin Barnett, Tania J. Bellinger, FlaviaTurcatoa, Kelly Schmidta, Yu Luo*, Cuprizone-induced demyelination under physiological and post-stroke condition leads to decreased neurogenesis response in adult mouse brain. Experimental Neurology, 2020.326:113168
5. Fucheng Luo#, Amanda Phuong Tran#, Li Xin, Chandrika Sanapala, Bradley T. Lang, Jerry Silver*, Yan Yang*, Modulation of proteoglycan receptor PTPσ enhances MMP-2 activity to promote recovery from multiple sclerosis. Nature Communications, 2018. DOI: 10.1038/s41467-018-06505-6
6. Fucheng Luo, Jessie Zhang, Kathryn Burk, Rita R. Romito-DiGiacomo, Robert H. Miller*, Yan Yang*, Oligodendrocyte-specific loss of Cdk5 disrupts the architecture of nodes of Ranvier as well as learning and memory. Experimental Neurology, 2018.306:92-104
7. Fucheng Luo, Karl Herrup, Xin Qi*, Yan Yang*, Inhibition of Drp1 hyper-activation is protective in animal models of experimental multiple sclerosis. Experimental Neurology, 2017.292:21-34
8. Fucheng Luo, Jessie Zhang, Kathryn Burke, Robert H. Miller*, Yan Yang*, The activators of Cdk5 p35 and p39 are essential for oligodendrocyte maturation, process formation and myelination. Journal of Neuroscience. 2016. 36(10):3024-3037
9. Fucheng Luo, Kathryn Burke, Christopher Kantor, Robert H. Miller*, Yan Yang*, Cyclin-dependent kinase 5 mediates adult OPC maturation and myelin repair through modulation of Akt and GsK-3beta signaling. Journal of Neuroscience, 2014. 34(31): p. 10415-29
10. Fucheng Luo, Yuemei Feng, Lu Zhao, Kui Li, Shengdong Wang, Junying Song, Jie Bai*, Thioredoxin-1 expression regulated by morphine in SH-SY5Y cells. Neuroscience Letters, 2012. 523(1): 50-5.
11. Fucheng Luo, Lei Qi, Tao Lv, Shengdong Wang,Hua Liu, Hajime Nakamura, Junji Yodoi, Jie Bai*, Geranylgeranylacetone protects mice against morphine-induced hyperlocomotion, rewarding effect, and withdrawal syndrome. Free Radical Biology and Medicine, 2012.52(7): 1218-27.
12. Fucheng Luo, Jia Zhou, Tao Lv, Lei Qi, Shengdong Wang, Hajime Nakamura, Junji Yodoi, Jie Bai*, Induction of endoplasmic reticulum stress and the modulation of thioredoxin-1 in formaldehyde-induced neurotoxicity. NeuroToxicology, 2012. 33(3): 290-8.
13. Fucheng Luo, Shengdong Wang, Lei Qi, Junying Song, Tao Lv, Jie Bai*, Protective effect of panaxatriol saponins extracted from Panax notoginseng against MPTP-induced neurotoxicity in vivo. Journal of Ethnopharmacology, 2011. 133(2): 448-53.
14. Fucheng Luo, Shengdong Wang, Kui Li, Hajime Nakamura, Junji Yodoi, Jie Bai*, Panaxatriol saponins extracted from Panax notoginseng induces thioredoxin-1 and prevents 1-methyl-4-phenylpyridinium ion-induced neurotoxicity. Journal of Ethnopharmacology, 2010. 127(2): 419-23.

六、招生与招聘

1．欢迎优秀的本科生和硕士报考实验室的硕士和博士研究生

2．实验室招聘博士后(若干名)、助理研究员和讲师

要求获得生物学博士学位，有发育神经生物学、干细胞生物学、神经电生理学、类脑器官培养或动物模型等工作经验；具有较好的研究背景，并在SCI期刊上以第一作者或通讯作者发表过较好的研究论文；具有独立研究工作能力和合作精神，善于交流，有良好的文字表达能力和协调沟通能力；有较强的英语听、说、读、写能力。