• 2022.09-至今 昆明理工大学灵长类转化医学研究院，副教授
• 2017.09-2022.06 清华大学，医学院，生物学，理学博士
• 2012.09-2017.06 哈尔滨医科大学，生物信息科学与技术学院，生物技术五年制，理学学士

• Sep 2022 – present Institute of Primate Translational Medicine, Kunming University of Science and Technology, Associate Professor.
• Sep 2017 – June 2022 Ph.D., Peking University-Tsinghua University-National Institute of Biological Science Joint Graduate Program, School of Medicine, Tsinghua University.
• Sep 2012 – June 2017 B.S., Harbin Medical University.

1. 免疫调控在肿瘤及衰老相关疾病中的作用

2. 复杂疾病的遗传学和生物信息学研究

3. 高通量组学大数据的整合分析与数据挖掘工具开发

4. 机器学习和深度学习在生物大数据挖掘上的应用

1. exploring the role of immune regulation in tumor and age-related diseases

2. Genetic research and bioinformatics applied to the study of complex diseases

3. Integrated analysis of high-throughput omics data and the development of data analysis tools

4. Application of machine learning and deep learning

研究方向聚焦免疫调控在衰老与肿瘤发生发展中的作用，融合统计学、计算机科学、基因组学与人工智能等交叉学科方法，基于高通量组学与生物医学大数据开发生物信息学工具，揭示相关机制，为疾病早期筛查和治疗提供科学依据。

My research focuses on the role of immune regulation in aging and cancer development and progression. By integrating approaches from statistics, computer science, genomics, and artificial intelligence, I develop bioinformatics tools using high-throughput omics and large-scale biomedical data to uncover underlying mechanisms and provide a scientific basis for early disease screening and treatment.

1. 国家自然科学基金项目，32300551，衰老进程中小胶质细胞的多样性解析及其炎性状态转化机制研究，2024.01-2026.12，30万，在研，主持。

2. 国家自然科学基金项目，32660174，胶质母细胞瘤中衰老样小胶质细胞的形成及其介导免疫抑制的机制研究，2027.01-2030.12，32万，在研，主持。

3. 云南省科技厅，基础研究专项—面上项目，202401CF070125，巨噬细胞介导免疫抑制性T细胞激活的促肿瘤机制研究，2024.03-2027.02，10万，在研，主持。

4. 中央引导地方科技发展资金项目，202507AB040007，2025.09-2027.08，400万元，在研，骨干。

5. 云南省教育厅，科学研究基金项目（2023J0141），单细胞转录组分析揭示小胶质细胞在脑部疾病中的调控作用，2023.3-2025.3，2万，结题，主持。

6.国家自然科学基金委员会面上项目，3247040809，调控hnRNPA2B1蛋白二聚化的小分子抑制剂的计算筛选、验证和抗衰老活性研究，2025.01 至 2028.12，51万，在研，参与。

1.Naixue Yang#, Hao Yuan#, Wei Wang#, Xinquan Liu#, Chang Liu, Yi Yao, Yue Li, Yibo Gao*, Xin Lin*, Mingchao Wang*, Xun Lan*. Pan-cancer macrophages atlas uncovers that MHC-IIhigh TAMs induce Treg activation through physical interactions. Cell Reports. 2026 Apr 10;45(4):117230. 中科院一区，IF=6.9

2.Naixue Yang#, Fansen Ji#, Liqing Cheng#, Jingzhe Lu#, Xiaofeng Sun, Xin Lin*, and Xun Lan*. Knockout of immunotherapy prognostic marker genes eliminates the effect of the anti-PD-1 treatment. Npj Precision Oncology. 2021 May 7;5(1):37. 中科院一区，IF=10.123

3.Yu Zheng#, Haihui Jiang#, Naixue Yang#, Shaoping Shen, Daosheng Huang, Lemei Jia, Jing Ling, Longchen Xu, Mingxiao Li, Kefu Yu, Xiaohui Ren, Yong Cui, Xun Lan, Song Lin*, Xin Lin*. Glioma-derived ANXA1 suppresses the immune response to TLR3 ligands by promoting an anti-inflammatory tumor microenvironment, Cellular＆Molecular Immunology. 2024, 21(1): 47-59. 中科院一区，IF=19.8

4.Yaping Yan#, Naixue Yang#, Kaixuan Lv#, Li Wu#, Tao Shen#, Yanchao Duan, Yue Sui, Yalian Sa, Qian Zhao, Shuai Qiu, Tianzhaung Huang, Dan Wang, Weizhi Ji*, Jianhong Hou*, Wei Si*. Mesenchymal Stromal Cells Enhance Cartilage Repair in Cynomolgus Macaques via Synovium Mediated WNT Inhibition and FOS/AP-1 Activation. Signal Transduction and Targeted Therapy. 2026.In Press. 中科院一区，IF=52.7

5.Shuyi Liu#, Naixue Yang#, Yaping Yan#, Shaobo Wang#, Jialing Chen, Yichao Wang, Xue Gan, Jiawen Zhou, Guoqing Xie, Hong Wang, Tianzhuang Huang, Weizhi Ji*, Zhengbo Wang*, Wei Si*. An accelerated Parkinson's disease monkey model using AAV-α-synuclein plus poly (ADP-ribose). Cell Reports Methods. 2024, 21;4(10):100876.

6.Shengnan Wang #, Yichao Wang#, Li Wu#, Xiang Shi, Yaping Yan, Lei Zhang, Weizhi Ji*, Naixue Yang*, Wei Si*. Single-cell atlas of rhesus monkey testis reveals aging- and season-dependent regulation of spermatogenesis and microenvironment homeostasis. International Journal of Biological Sciences. 2026, 22(12):6858-6875.

7.Keyong Sun#, Runda Xu#, Fuhai Ma#, Naixue Yang#,Yang Li#, Xiaofeng Sun, Peng Jin, Wenzhe Kang, Lemei Jia, Jianping Xiong, Haitao Hu, Yantao Tian*, Xun Lan*. scRNA-seq of gastric tumor shows complex intercellular interaction with an alternative T cell exhaustion trajectory. Nature Communications. 2022 Aug 23;13(1):4943.

8.Li Wu, Renxin Zhang, Yichao Wang, Shaoxing Dai*, Naixue Yang*. Integrative single-cell and cell-free plasma RNA transcriptomics identifies biomarkers for early non-invasive AD screening. Frontiers in aging neuroscience. 2025, 30;17:1571783.

9.Jihao Liang, Yang Zheng, Xin Tong, Naixue Yang*, and Shaoxing Dai*. In Silico Identification of Anti-SARS-CoV-2 Medicinal Plants Using Cheminformatics and Machine Learning. Molecules. 2022 Dec 26;28(1):208.

10.Yichao Wang, Hao Yuan, Yayun Tan, Li Wu, Xinchen Zhao, Zeyuan Yang, Shaoxing Dai*, Naixue Yang*. A novel Tc17 population recruited by tumor cells promotes tumor progression in gastric cancer. Frontiers in oncology. 2025 May 16;15:1592328. doi: 10.3389/fonc.2025.1592328.

11.Liqing Cheng, Nan Deng, Naixue Yang, Xueqiang Zhao, and Xin Lin*. 2019. Malt1 Protease Is Critical in Maintaining Function of Regulatory T Cells and May Be a Therapeutic Target for Antitumor Immunity. Journal of Immunology. 2019 May 15;202(10):3008-3019.

(1) 司维;严亚萍;杨耐雪,分泌型卷曲相关蛋白在制备关节炎治疗药物上的应用及关节炎治疗药物, 发明专利, 授权, 2026-06-16, 中国, ZL 2025 1 0961652.X.

(2) 代绍兴;陈志远;吕豪豪;周子昂;杨耐雪,一种基于化合物扰动转录组和蛋白序列预测化合物靶 点的方法及应用,发明专利, 授权, 2025-09-30, 中国, ZL 2024 1 1934177.9.

(3) 杨耐雪;马文倩;伍黎;王毅超;代绍兴,基于机器学习筛选早期非侵入性阿尔兹海默病筛查的生 物标志物的方法,发明专利, 申请, 2025-05-30, 中国, 202510158559.5.

(4) 代绍兴;庞莘瀚;许敏;李金峻;杨鹏鹏;杨耐雪;朱然,金松双黄酮在制备提高细胞活力及抗衰老 产品中的应用,发明专利, 申请, 2025-12-09, 中国, 202511848195.X.

(5) 代绍兴;周子昂;刘伟;许敏;李金峻;杨耐雪;杨鹏鹏;朱然;伍黎,一种基于氨基酸配对距离编码 的蛋白质口袋特征化方法及其应用,发明专利, 申请, 2025-12-09, 中国, 202511848187.5.

(6) 代绍兴;武博涵;许敏;李金峻;杨耐雪;杨鹏鹏;朱然;伍黎,拟人参皂苷RT5在制备升白细胞药物和肿瘤治疗支 持药物中的应用,发明专利, 申请, 2025-12-09, 中国, 202511848189.4.

(7) 代绍兴;李金峻;许敏;武博涵;杨耐雪;杨鹏鹏;朱然;伍黎,拟人参皂苷RT5在制备抗细胞和整体 衰老产品中的应用,发明专利, 申请, 2025-12-09, 中国, 202511848191.1.

1.云南省“兴滇英才支持计划”青年拔尖人才， 2024。

2.优秀青年研究奖，省部共建非人灵长类生物医学国家重点实验室，青年研究奖，2024。

3.清华大学优秀毕业生启航奖，清华大学， 2022。

欢迎对生物信息、人工智能等交叉领域感兴趣的同学加入我们，在这里没有师生只有并肩作战的朋友！

招生专业：071007-遗传学

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