谭韬(Tao Tan)

• 2000年―2004年， 兰州大学生命科学学院，生物科学学士学位。
• 2004年―2010年， 中国科学院昆明动物研究所，动物学专业，干细胞生物学研究方向获理学博士学位
• 2010年4月—2012年5月，中国科学院昆明动物研究所，助理研究员
• 2012年6月—2014年9月，云南中科灵长类生物医学重点实验室，副研究员
• 2014年10月—2019年7月，昆明理工大学灵长类转化医学研究中心，副教授
• 2019年8月—至今，昆明理工大学灵长类转化医学研究院，教授

1. 灵长类着床前胚胎谱系分化及功能维持调控机理；
2. 灵长类原肠运动发育特征与调控模式；
3. 灵长类早期器官发生关键事件与调控机制；
4. 灵长类原始生殖细胞特化机制与体外重建。

1. 国家杰出青年科学基金，82425025，早期胚胎发育及其异常的生理病理机制，2025-2029，400万元，主持；
2. 云南省基础研究计划-重大项目，202401BC070020，灵长类早期胚胎发育调控及其相关疾病机制研究，2024年-2027年，300万元，主持；
3. 国家自然科学基金，82192871，早期胚胎发育与不良妊娠结局-课题一：灵长类早期胚胎发育与出生缺陷，2022-2026，300万元，主持；
4. 国家重点研发计划，2018YFA0801402，创建疾病早期发育调控机理研究新技术-课题二：发育、代谢复杂疾病灵长类动物模型的创制与临床前研究，2019年-2024年，988万元，主持。
5. 国家自然科学基金-地区基金，81760271，以食蟹猴胚胎体外延时培养为模型研究灵长类早期着床后胚胎细胞谱系分化，2018-2021，34万元，主持。

1. Han Xie, Chenrui An, Bing Bai, Jiajia Luo, Nianqin Sun, Baiquan Ci, Long Jin, Peiting Mo, Yawen Lu, Ke Zhong, Yang Yu, Tao Tan, Rong Li, Yong Fan. (2025). Modeling early gastrulation in human blastoids with DNA methylation patterns of natural blastocysts. Cell stem cell, 32(3), 409–425.e8.
2. Tao Tan, Xiao Lu, Tianqing Li, Jingkuan Wei, Hongmei Wang, Weizhi Ji. (2025). An exploratory proposal for a revision to the 14-day rule in the regulatory context of China. Cell stem cell, 32(12), 1798–1801.
3. Yulei Wei, E Zhang, Leqian Yu, Baiquan Ci, Masahiro Sakurai, Lei Guo, Xin Zhang, Sirui Lin, Shino Takii, Lizhong Liu, Jian Liu, Daniel A Schmitz, Ting Su, Junmei Zhang, Qiaoyan Shen, Yi Ding, Linfeng Zhan, Hai-Xi Sun, Canbin Zheng, Lin Xu, Daiji Okamura, Weizhi Ji, Tao Tan, Jun Wu. (2023). Dissecting embryonic and extraembryonic lineage crosstalk with stem cell co-culture. Cell, 186(26), 5859–5875.e24.
4. Yaqian Li, Jian Liu, Ye Zhang, Meng Mao, Hong Wang, Yidi Ma, Zhigang Chen, Youyue Zhang, Chengmin Liao, Xiaoqing Chang, Qianqian Gao, Jianbin Guo, Yang Ye, Fangfang Ai, Xudong Liu, Xiaoyue Zhao, Weijie Tian, Hua Yang, Weizhi Ji, Tao Tan, Lan Zhu. 2023). A comprehensive evaluation of spontaneous pelvic organ prolapse in rhesus macaques as an ideal model for the study of human pelvic organ prolapse. Science bulletin, 68(20), 2434–2447.
5. Xi Dai, Honglian Shao, Nianqin Sun, Baiquan Ci, Jun Wu, Chuanyu Liu, Liang Wu, Yue Yuan, Xiaoyu Wei, Huanming Yang, Longqi Liu, Weizhi Ji, Bing Bai, Zhouchun Shang, Tao Tan. (2022). Developmental dynamics of chromatin accessibility during post-implantation development of monkey embryos. GigaScience, 12, giad038.
6. Yandong Gong, Bing Bai, Nianqin Sun, Baiquan Ci, Honglian Shao, Ting Zhang, Hui Yao, Youyue Zhang, Yuyu Niu, Lizhong Liu, Hu Zhao, Hao Wu, Lei Zhang, Tianxiang Wang, Shangang Li, Yulei Wei, Yang Yu, Ana Elisa Ribeiro Orsi, Bing Liu*, Weizhi Ji*, Jun Wu*, Yongchang Chen*, Tao Tan*. Ex utero monkey embryogenesis from blastocyst to early organogenesis.cell.2023 May 11.186(10):2092-2110
7. Tao Tan# , Jun Wu# , Chenyang Si# , Shaoxing Dai# , Youyue Zhang#, Nianqin Sun , E Zhang , Honglian Shao , Wei Si , Pengpeng Yang , Hong Wang , Zhenzhen Chen , Ran Zhu , Yu Kang , Reyna Hernandez-Benitez , Llanos Martinez Martinez , Estrella Nuñez Delicado , W Travis Berggren , May Schwarz , Zongyong Ai , Tianqing Li , Concepcion Rodriguez Esteban* , Weizhi Ji* , Yuyu Niu* , Juan Carlos Izpisua Belmonte* Chimeric contribution of human extended pluripotent stem cells to monkey embryos ex vivo.cell.2021 Apr 15.184(8):2020-2032
8. Yuyu Niu*,Nianqin Sun,Chang Li,Ying Lei,Zhihao Huang,Jun Wu,Chenyang Si,Xi Dai,Chuanyu Liu,Longqi Liu,Su Feng,Yu Kang,Wei Si,Hong Wang,E. Zhang,Lu Zhao,Ziwei Li,Xi Luo,Guizhong Cui,Guangdun Peng,Juan Carlos Izpisúa Belmonte*,Weizhi Ji*,Tao Tan*. Dissecting primate early post-implantation development using long-term in vitro embryo culture. Science. 366(6467),[IF:41.037]
9. Improved tagmentation-based whole-genome bisulfite sequencing for input DNA from less than 100 mammalian cells.Hanlin Lu 1, Zhimei Yuan, Tao Tan, Junwen Wang, Juyong Zhang, Hui-Juan Luo, Yudong Xia, Weizhi Ji, Fei Gao*. Epigenomics. 2015 Feb;7(1):47-56. doi: 10.2217/epi.14.76.
10. miRNA signature in mouse spermatogonial stem cells revealed by high-throughput sequencing.Tao Tan, Yanfeng Zhang, Weizhi Ji*, Ping Zheng*. Biomed Res Int. 2014;2014:154251. doi: 10.1155/2014/154251.
11. Notch1 signaling antagonizes transforming growth factor-β pathway and induces apoptosis in rabbit trophoblast stem cells.Tao Tan, Bin Lu, Jing Zhang, Yuyu Niu, Wei Si, Qiang Wei, Weizhi Ji*. Stem Cells Dev. 2014 Apr 15;23(8):813-22. doi: 10.1089/scd.2013.0280.
12. Aberrant expression of maternal Plk1 and Dctn3 results in the developmental failure of human in-vivo- and in-vitro-matured oocytes.Yong Fan, Hong-Cui Zhao, Jianqiao Liu, Tao Tan, Ting Ding, Rong Li, Yue Zhao, Jie Yan, Xiaofang Sun, Yang Yu, Jie Qiao. Sci Rep. 2015 Feb 3;5:8192. doi: 10.1038/srep08192.
13. Generation of trophoblast stem cells from rabbit embryonic stem cells with BMP4.Tao Tan, Xianghui Tang, Jing Zhang, Yuyu Niu, Hongwei Chen, Bin Li, Qiang Wei, Weizhi Ji*. PLoS One. 2011 Feb 17;6(2):e17124. doi: 10.1371/journal.pone.0017124.
14. TALEN-mediated gene mutagenesis in rhesus and cynomolgus monkeys.Hailiang Liu #, Yongchang Chen #, Yuyu Niu #, Kunshan Zhang #, Yu Kang, Weihong Ge, Xiaojing Liu, Enfeng Zhao, Chencheng Wang, Shaoyun Lin, Bo Jing, Chenyang Si, Quan Lin, Xiaoying Chen, Haijun Lin, Xiuqiong Pu, Yingying Wang, Binlian Qin, Fang Wang, Hong Wang, Wei Si, Jing Zhou, Tao Tan, Tianqing Li, Shaohui Ji, Zhigang Xue, Yuping Luo, Liming Cheng, Qi Zhou, Siguang Li*, Yi Eve Sun*, Weizhi Ji*. Cell Stem Cell. 2014 Mar 6;14(3):323-8. doi: 10.1016/j.stem.2014.01.018
15. Yuyu Niu, Bin Shen, Yiqiang Cui, Yongchang Chen, Jianying Wang, Lei Wang, Yu Kang, Xiaoyang Zhao, Wei Si, Wei Li, Andy Peng Xiang, Jiankui Zhou, Xuejiang Guo, Ye Bi, Chenyang Si, Bian Hu, Guoying Dong, Hong Wang, Zuomin Zhou, Tianqing Li, Tao Tan, Xiuqiong Pu, Fang Wang, Shaohui Ji, Qi Zhou, Xingxu Huang*, Weizhi Ji*, Jiahao Sha*. Cell. 2014 Feb 13;156(4):836-43. doi: 10.1016/j.cell.2014.01.027.
16. Derivation of rhesus monkey parthenogenetic embryonic stem cells and its microRNA signature.Qiang Wei, Zhenghua Sun, Xiechao He, Tao Tan, Bin Lu, Xiangyu Guo, Bing Su, Weizhi Ji*. PLoS One. 2011;6(9):e25052. doi: 10.1371/journal.pone.0025052.
17. Transgenic rhesus monkeys produced by gene transfer into early-cleavage-stage embryos using a simian immunodeficiency virus-based vector.Yuyu Niu, Yang Yu, Agnieszka Bernat, Shihua Yang, Xiechao He, Xiangyu Guo, Dongliang Chen, Yongchang Chen, Shaohui Ji, Wei Si, Yongqin Lv, Tao Tan, Qiang Wei, Hong Wang, Lei Shi, Jean Guan, Xuemei Zhu, Marielle Afanassieff, Pierre Savatier, Kang Zhang, Qi Zhou*, Weizhi Ji*. Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17663-7. doi: 10.1073/pnas.1006563107.
18. Directional freezing as an alternative method for cryopreserving rhesus macaque (Macaca mulatta) sperm.Wei Si, Yongqing Lu, Xiechao He, Shaohui Ji, Yuyu Niu, Tao Tan, Weizhi Ji*. Theriogenology. 2010 Nov;74(8):1431-8. doi: 10.1016/j.theriogenology.
19. Netrin-1 signaling mediates NO-induced glial precursor migration and accumulation.Hongwei Chen, Qiang Wei, Jing Zhang, Chuangkun Xu, Tao Tan, Weizhi Ji*. Cell Res. 2010 Feb;20(2):238-41. doi: 10.1038/cr.2010.7.

邮箱：sunnq@lpbr.cn

2010-2014年，西昌学院，动物医学，学士；

2014-2016，西北农林科技大学，兽医学（胚胎工程），硕士；

2016-2018年 ，云南中科灵长类转化医学重点实验室，实验技术员；

2018-2022年，昆明理工大学，发育生物学，博士；

2022-2024年，昆明理工大学，灵长类转化医学研究，博士后；

2024.11-至今，昆明理工大学，灵长类转化医学研究院，校聘副教授。

灵长类早期胚胎发育与器官发生调控机制

建立非人灵长类二维及三维体外长时程培养体系，并阐明非人灵长类早期原肠运动发育特征与调控模式；揭示非人灵长类胚胎中晚期原肠运动至早期器官发生过程的重要细胞组成及谱系分化轨迹，首次精确识别并系统解析了灵长类第一波造血发生及调控机制，填补了领域知识空白。

1. 国家自然科学基金-青年基金, 利用体外长时程培养体系解析食蟹猴心血管系统早期发育进程的研究, 2024.01-2026.12，30万元，主持；

2. 云南省基础研究项目-面上项目，体外仿生培养体系解析灵长类胚胎体节发生分子机制的研究，2024.06-2027.05，10万元，主持。

3. 国家重点研发计划-发育编程及其代谢调节，课题二：灵长类胚胎长时程培养体系建立及早期胚胎发育调控机制，150/850万元，课题骨干。

4. 云南省基础研究项目-青年基金，小鼠入后早期胚胎体外培养体系建立及应用，2019.10-2022.09，5万元，主持；

5. 国家自然科学基金-重大项目，课题一：灵长类早期胚胎发育与出生缺陷，2022.01-2026.12，300万元，参与（3/10）；

6. 国家重点研发计划-发育编程及其代谢调节，课题二：创建早期发育调控机理研究新技术，2019年11月-2024年10月，988万元，参与（8/20）。

1. Yandong Gong; Bing Bai; Nianqin Sun（孙念琴，共一）; Baiquan Ci; Honglian Shao; Ting Zhang; Hui Yao; Youyue Zhang; Yuyu Niu; Lizhong Liu; Hu Zhao; Hao Wu; Lei Zhang; Tianxiang Wang; Shangang Li; Yulei Wei; Yang Yu; Ana Elisa Ribeiro Orsi; Bing Liu; Weizhi Ji; Jun Wu; Yongchang Chen; Tao Tan ; Ex utero monkey embryogenesis from blastocyst to early organogenesis, Cell, 2023, 186(10): 2092-2110.

2. Yuyu Niu; Nianqin Sun（孙念琴，共一）; Chang Li; Ying Lei; Zhihao Huang; Jun Wu; Chenyang Si; Xi Dai; Chuanyu Liu; Jinkuan Wei; Longqi Liu; Yu kang; Wei Si; Hong Wang; E Zhang; Lu Zhao; Ziwei Li; Xi Luo; Guangdun Peng; Juan Carlos Izpisúa Belmonte; Weizhi Ji; Tao Tan; Dissecting primate early post-implantation development using longterm in vitro embryo culture, Science, 2019, 336(6467):1-20.

3. Xi Dai; Honglian Shao; Nianqin Sun（孙念琴，共一）; Baiquan Ci; Jun Wu; Chuanyu Liu; Liang Wu; Yue Yuan; Xiaoyu Wei; Huanming Yang; Longqi Liu; Weizhi Ji; Bing Bai; Zhouchun Shang; Tao Tan; Developmental dynamics of chromatin accessibility during post-implantation development of monkey embryos, Gigascience, 2022, 12: 1-14.

4. Nianqin Sun（孙念琴，共一兼共通）; Honglian Shao; Youyue Zhang; Baiquan Ci; Hui Yao; Bing Bai; Tao Tan ; Establishing a 3D culture system for early organogenesis of monkey embryos ex vivo and single cell transcriptome analysis of cultured embryos, Star protocol, 2024, 5(1): 1-34.

5. Tao Tan; Jun Wu; Chenyang Si; Shaoxing Dai; Youyue Zhang; Nianqin Sun（孙念琴，主要参与）; E Zhang; Honglian Shao; Wei Si; Pengpeng Yang; Hong Wang; Zhenzhen Chen; Ran Zhu; Yu Kang; Reyna Hernandez-Benitez; Llanos Martinez Martinez; Estrella Nunez Delicado; W. Travis Berggren; May Schwarz; Zongyong Ai; Tianqing Li; Concepcion Rodriguez Esteban; Weizhi Ji; Yuyu Niu; Juan Carlos Izpisua Belmonte; Chimeric contribution of human extended pluripotent stem cells to monkey embryos ex vivo, Cell, 2021, 184(8): 2020-2032