• 季维智(Weizhi Ji)

    中国科学院院士,欧洲科学院院士

    博士生导师,昆明理工大学特聘教授

    灵长类转化医学院 院长

    省部共建非人灵长类生物医学国家重点实验室 主任

    云南中科灵长类生物医学重点实验室 理事长

    Member of Chinese Academy of Sciences, Member of Academia Europaea

    Distinguished Professor, Kunming University of Science and Technology

    Director, Institute of Primate Translational Medicine, Kunming University of Science and Technology

    Director, the State Key Laboratory of Non-Human Primate Biomedicine;Yunnan Key Laboratory of Primate Biomedical Research

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    E-mail:wji@lpbr.cn

    一、简历(Biography)

    季维智,中国科学院院士,欧洲科学院院士,省部共建非人灵长类生物医学国家重点实验室主任,昆明理工大学灵长类转化医学研究院院长。长期坚持灵长类生殖发育生物学的研究,围绕早期胚胎发育调控,干细胞多能性和人类疾病的猴模型及致病机理等科学问题,形成了从体外受精、胚胎早期发育、基因编辑以及干细胞等系统研究体系。率先在基因编辑灵长类动物模型取得重大突破,并获得了naïve猴多能性干细胞。实现了灵长类(人和猴)胚胎体外延长培养,解析了灵长类胚胎发育原肠发生与发育的重要事件,获得全球首例人猴嵌合体胚胎,实现食蟹猴胚胎体外培养至25天。在 Cell,Science, Nature, Cell Stem Cell,PNAS等杂志以通讯作者或第一作者发表 SCI 论文 100 余篇,其中,2014 年在 Cell 发表的基因编辑猴的论文被评价为人类疾病模型建立的里程碑性工作、入选 2014 年世界十大科技进展(MIT Technology Review)、2014 年 Cell 最佳论文(Cell)、 2014 年世界最成功的 8 大事件之一(Nature)。2021年发表的全球首例人猴嵌合胚胎被Nature、Cell杂志评选为“2021年最佳科学图片”。曾获“何梁何利基金科学与技术进步奖生命科学奖”、“谈家桢生命科学成就奖”、“中国细胞生物学学会终身贡献奖”、“中国细胞生物学学会干细胞生物学分会杰出贡献科学家奖”、“云南省科学技术杰出贡献奖”。2024年入选Cell “全球科学50人”之一 2021年,发起成立“灵长类研究创新联盟”,联盟的成立对该领域人才培养、科学研究、成果转化、临床应用等产生重要的积极推动作用。

    Weizhi Ji, a Member of Chinese Academy of Sciences (CAS), and a member of Academia Europaea, and Professor and Director of the State Key Laboratory of Primate Biomedical Research at the Institute of Primate Translational Medicine at Kunming University of Science and Technology, was selected as one of the Cell Press 50 Scientists that Inspire for his leadership in primate reproductive biology and developmental biology research.

    Over the last three decades, Prof. Ji has focused on developing non-human primate disease models and on advancing regenerative and developmental biology with the overarching aim of improving human health. His research looks at the mechanisms of early embryo development regulation, stem cell pluripotency, and nonhuman primate models for human neurodevelopmental and neurodegenerative diseases.

    Prof. Ji’s research has been published in internationally recognized journals, including Cell, Science, Nature, Cell Stem Cell, PNAS and others. Notably, his lab developed the first gene-modified rhesus and cynomolgus monkeys via Cas9/RNA-mediated gene targeting in 2014, first proved the feasibility to generate chimeric monkeys using ESCs in 2015 and succeeded in extending in vitro culture for monkey in 2019 and for human early embryos in 2020. In 2021, leveraging the embryo in vitro culture system, his lab generated the first human-monkey chimeras. And in 2023, the team developed an embedded 3D culture system that allows for the extended ex utero culture of cynomolgus monkey embryos for up to 25 days post-fertilization. In 2024, Prof. Ji’s team revealed that profound cellular defects attribute to muscular pathogenesis in the rhesus monkey model of Duchenne muscular dystrophy(DMD), which provides therapeutic targets for antifibrotic drugs and muscle regeneration therapies, as well as a reliable platform for advancing gene and cell therapies and new drug development.

    二、近五年相关论文(Publications)

    1. Yu Kang#, Shaoxing Dai#, Yuqiang Zeng#, Fang Wang#, Pengpeng Yang, Zhaohui Yang, Youwei Pu1,3, Zifan Li, Xinglong Chen1, Baohong Tian, Wei Si, Weizhi Ji*, Yuyu Niu*. Cloning and base editing of GFP transgenic rhesus monkey and off-target analysis. Science Advances. 2022.7 8(29):1-11 [IF: 14.957]
    2. Tao Tan# , Jun Wu# , Chenyang Si# , Shaoxing Dai# , Youyue Zhang#, Nianqin Sun , E Zhang , Honglian Shao , Wei Si , Pengpeng Yang , Hong Wang , Zhenzhen Chen , Ran Zhu , Yu Kang , Reyna Hernandez-Benitez , Llanos Martinez Martinez , Estrella Nuñez Delicado , W Travis Berggren , May Schwarz , Zongyong Ai , Tianqing Li , Concepcion Rodriguez Esteban* , Weizhi Ji* , Yuyu Niu* , Juan Carlos Izpisua Belmonte* Chimeric contribution of human extended pluripotent stem cells to monkey embryos ex vivo.cell.2021 Apr 15.184(8):2020-2032
    3. Ran Yang, Alexander Goedel, Yu Kang, Chenyang Si, Chu Chu, Yi Zheng, Zhenzhen Chen, Peter J. Gruber, Yao Xiao, Chikai Zhou, Nevin Witman, Elif Eroglu, Chuen-Yan Leung, Yongchang Chen, Jianping Fu, Weizhi Ji*, Fredrik Lanner*, Yuyu Niu* & Kenneth R. Chien*.Amnion signals are essential for mesoderm formation in primates.Nature Communications.26 August 2021.12: 5126 (2021)
    4. Zongyong Ai, Baohua Niu, Kui Duan, Chenyang Si, Sile Wang, Lifeng Xiang, Xiaoqing Zhu, Qingyuan Zhu, Chun Feng, Yu Yin, Shumei Zhao, Ruize Kong, Weizhi Ji, Tianqing Li. Modulation of Wnt and Activin/Nodal supports efficient derivation, cloning and suspension expansion of human pluripotent stem cells. Biomaterials. 2020;249:120015. doi:10.1016/j.biomaterials.August 2020
    5. Fang Wang, Weiqi Zhang, Qiaoyan Yang , Yu Kang , Yanling Fan, Jingkuan Wei , Zunpeng Liu,Shaoxing Dai , Hao Li, Zifan Li, Lizhu Xu , Chu Chu, Jing Qu, Chenyang Si, Weizhi Ji*,Guang-Hui Liu*, Chengzu Long*, Yuyu Niu*. Generation of a Hutchinson–Gilford progeria syndrome monkey model by base editing. Protein Cell (2020). https://doi.org/10.1007/s13238-020-00740-8.29 July 2020
    6. Lifeng Xiang, Yu Yin, Yun Zheng, Yanping Ma, Yonggang Li, Zhigang Zhao, Junqiang Guo, Zongyong Ai, Yuyu Niu, Kui Duan, Jingjing He, Shuchao Ren, Dan Wu, Yun Bai, Zhouchun Shang, Xi Dai, Weizhi Ji, Tianqing Li.A developmental landscape of 3D-cultured human pre-gastrulation embryos.Nature(2019) doi:10.1038/s41586-019-1875-y,12 December 2019
    7. Yuyu Niu*,Nianqin Sun,Chang Li,Ying Lei,Zhihao Huang,Jun Wu,Chenyang Si,Xi Dai,Chuanyu Liu,Longqi Liu,Su Feng,Yu Kang,Wei Si,Hong Wang,E. Zhang,Lu Zhao,Ziwei Li,Xi Luo,Guizhong Cui,Guangdun Peng,Juan Carlos Izpisúa Belmonte*,Weizhi Ji*,Tao Tan*. Dissecting primate early post-implantation development using long-term in vitro embryo culture. Science. 366(6467) :15 Nov 2019
    8. Shanshan Li, Lei Ao, Yaping Yan, Jiang Jiang, Bingbing Chen, Yanchao Duan, Fei Shen, Jinbao Chen,Briauna Inglis, Renmin Ni, Weizhi Ji* and Wei Si*.Differential motility parameters and identification of proteomic profiles of human sperm cryopreserved with cryostraw and cryovial. Clin Proteom. 16, 24 (2019) doi:10.1186/s12014-019-9244-2,19 June 2019
    9. Lei Shi, Xin Luo, Jin Jiang, Yongchang Chen, Cirong Liu, Ting Hu, Min Li, Qiang Lin, Yanjiao Li, Jun Huang, Hong Wang, Yuyu Niu, Yundi Shi, Martin Styner, Jianhong Wang, Yi Lu, Xuejin Sun, Hualin Yu, Weizhi Ji, Bing Su, Transgenic rhesus monkeys carrying the human MCPH1 gene copies show human-like neoteny of brain development, National Science Review, Volume 6, Issue 3, May 2019, Pages 480–493,27 March 2019
    10. Hong Wang, Yaping Yan, Xiaoyan Yi, Yanchao Duan, Junfeng Wang, Shanshan Li Lilin Luo, Tianzhuang Huang, Briauna Inglis, Xi Li, Weizhi Ji, Tao Tan* and Wei Si*. Histopathologilal Features and Composition Of Gut Microbiota in Rhesus Monkey of Alcoholic Liver disease Frontiers in Microbiology. Front Microbiol,Volume 10,165. 08 February 2019
    11. Bo Zhang,Zhigang Zhou,Yin Zhou,Ting Zhang,Yuanye Ma,Yuyu Niu,Weizhi Ji,Yongchang Chen.Social-valence-related increased attention in Rett syndrome cynomolgus monkeys: An eye-tracking study. Autism Res. Volume12, Issue11,November 2019,1585-1597,07 August 2019
    12. Tianqing Li*,Zongyong Ai,Weizhi Ji*.Primate stem cells: bridge the translation from basic research to clinic application. SCIENCE CHINA Life Sciences. 2019 62(1):12-21,09 August 2018
    13. Chu Chu, Zhaohui Yang, Jiayin Yang, Li Yan, Chenyang Si, Yu Kang, Zhenzhen Chen, Yongchang Chen,Weizhi Ji and Yuyu Niu*.Homologous recombination-mediated targeted integration in monkey embryos using TALE nucleases. BMC Biotechnology. 19, 7 (2019),doi:10.1186/s12896-018-0494-2,15 January 2019
    14. Bin Jiang, Xufeng Fu, Li Yan, Shanshan Li, Dongliang Zhao, Xiaoyan Wang, Yanchao Duan,Yaping Yan, Enqin Li, Kunhua Wu, Briauna Marie Inglis, Weizhi Ji, Ren-He Xu, Wei Si.Transplantation of human ESC-derived mesenchymalstem cell spheroids ameliorates spontaneous osteoarthritis in rhesus macaques. Theranostics. 2019,9(22): 6587–6600. 2019 Aug 21
    15. Li Yan, Bin Jiang, Yuyu Niu, Hongxuan Wang, Enqin Li, Yaping Yan, Huiyan Sun, Yanchao Duan,Shaohui Chang, Guokai Chen, Weizhi Ji*, Ren-He Xu* and Wei Si*.Intrathecal delivery of human ESC-derived mesenchymal stem cell spheres promotes recovery of a primate multiple sclerosis model. Cell Death Discovery. 4, 89 (2018):1551-4005. 20 August 2018
    16. Shuang Wang,Lichuan Yang, Raoxian Bai, Shuaiwei Ren, Yuyu Niu, Weizhi Ji,Yuanye Ma,Yongchang Chen*.Interaction of p53 and ASPPs Regulates Rhesus Monkey Embryonic Stem Cells Conversion to Neural Fate Concomitant with Apoptosis. Cell Cycle. 17(9):1146-1153, 25 Jul 2018
    17. Shuang Wang,Shuaiwei Ren,Raoxian Bai,Puhao Xiao,Qin Zhou,Yin Zhou,Zhigang Zhou,Yuyu Niu,Weizhi Ji and Yongchang Chen.No off-target mutations in functional genome regions of aCRISPR/Cas9-generated monkey model of musculardystrophy. JBC ACCELERATED COMMUNICATION. 293,11654-11658. June 25, 2018
    18. Yiqiang Cui,Yuyu Niu,Jiankui Zhou,Yongchang Chen, Yiwei Cheng, Shangang Li,Zongyong Ai, Chu Chu, Hong Wang, Bo Zheng,Xuejin Chen, Jiahao Sha, Xuejiang Guo,Xingxu Huang, Weizhi Ji. Generation of a precise Oct4-hrGFP knockin cynomolgusmonkey model via CRISPR/Cas9-assisted homologous recombination. Cell Research.28,(2018):383-386. 12 January 2018
    19. Xufeng Fu, Bin Jiang, Bingrong Zheng, Yaping Yan, Junfeng Wang,Yanchao Duan, Shanshan Li, Li Yan, Hong Wang, Bingbing Chen,Xiongbo Sang, Weizhi Ji, Ren-He Xu* and Wei Si*. Heterogenic transplantation of bone marrow-derived rhesus macaque mesenchymal stem cells ameliorates liver fibrosis induced by carbon tetrachloride in mouse. Peer J.6:e4336. February 12, 2018
    20. Yu Kang, Zongyong Ai, Kui Duan, Chenyang Si, Yong Wang, Yun Zheng, Jingjing He, Yu Yin, Shumei Zhao, Baohua Niu, Xiaoqing Zhu, Li Liu, Lifeng Xiang, Linming Zhang, Yuyu Niu, Weizhi Ji, and Tianqing Li*. Improving Cell Survival in Injected Embryos Allows Primed Pluripotent Stem Cells to Generate Chimeric Cynomolgus Monkeys. Cell Reports. 25(9),2563-2576,27 November 2018
    21. Yuyu Niu, Tianqing Li and Weizhi Ji*.Paving the road for biomedicine: genome editing and stem cells in primates[J]. Stem Cell Research. Volume 4, Issue 4, July 2017, 543–549, 25 August 2017
    22. Fei Gao, Yuyu Niu, Yi Eve Sun, Hanlin Lu, Yongchang Chen, Siguang Li, Yu Kang, Yuping Luo, Chenyang Si, Juehua Yu, Chang Li, Nianqin Sun, Wei Si, Hong Wang, Weizhi Ji*, Tao Tan*.De novo DNA methylation during monkey pre-implantation embryogenesis[J]. Cell Res. 27, 526–539(2017),24 February 2017
    23. Yongchang Chen, Juehua Yu, Yuyu Niu, Dongdong Qin, Hailiang Liu, Gang Li, Yingzhou Hu, Jiaojian Wang, Yi Lu, Yu Kang, Yong Jiang, Kunhua Wu, Siguang Li, Jingkuan Wei, Jing He, Junbang Wang, Xiaojing Liu, Yuping Luo, Chenyang Si, Raoxian Bai, Kunshan Zhang, Jie Liu, Shaoyong Huang, Zhenzhen Chen, Shuang Wang, Xiaoying Chen, Xinhua Bao, Qingping Zhang, Fuxing Li, Rui Geng, Aibin Liang, Dinggang Shen, Tianzi Jiang, Xintian Hu, Yuanye Ma, Weizhi Ji*, Yi Eve Sun*. Modeling Rett Syndrome Using TALEN-Edited MECP2 Mutant Cynomolgus Monkeys[J]. Cell. Volume 169, Issue 5, 945-955.e10, 18 May 2017
    24. Bingbing Chen, Shanshan Li, Yaping Yan, Yanchao Duan, Shaohui Chang, Hong Wang, Weizhi Ji*, Xin Wu*, Wei Si*.Cryopreservation of cynomolgus macaque (Macaca fascicularis) sperm with glycerol and ethylene glycol, and its effect on sperm-specific ion channels - CatSper and Hv1. Theriogenology. Volume 104, 37-42,, December 2017
    25. Yan Zhuo, Shuqing Feng, Shaoyong Huang, Xinglong Chen, Yu Kang, Chenyang Si, Zifan Li, Yin Zhou, Ling Zhou, Ting Zhang, Weizhi Ji, Yuyu Niu*, Yongchang Chen*.Transabdominal Ultrasound-guided Multifetal Pregnancy Reduction in 10 Cases of Monkeys. Biology of Reproductio. Volume 97, Issue 5, November 2017, 758–761, 23 October 2017
    26. Xufeng Fu, Yaping Yan, Shanshan Li, Junfeng Wang, Bin Jiang, Hong Wang, Yanchao Duan, Tao Tan, Fei Gao, Desheng Gong, Yuyu Niu, Weizhi Ji*, Bingrong Zheng, Wei Si*.Vitrification of Rhesus Macaque Mesenchymal Stem Cells and the Effects on Global Gene Expression. Stem Cells International. Volume 2017,14 ,24 October 2017
    27. Yongchang Chen, Yuyu Niu, Weizhi Ji. Genome editing in nonhuman primates: approach to generating human disease models[J]. J Intern Med. Volume280, Issue3,September 2016, 246-251. 25 April 2016
    28. Xiaoqing Zhu, Bo Li, Zongyong Ai, Zheng Xiang, Kunshang Zhang, Xiaoyan Qiu, Yongchang Chen, Yuemin Li, Joshua D Rizak, Yuyu Niu, Xintian Hu, Yi Eve Sun, Weizhi Ji*, Tianqing Li*.A Robust Single Primate Neuroepithelial Cell Clonal Expansion System for Neural Tube Development and Disease Studies[J]. Stem Cell Reports. Volume 6, Issue 2,228-242, 9 February 2016
    29. Jingjing He, Zheng Xiang, Xiaoqing Zhu, Zongyong Ai, Jingsong Shen, Tianzhuang Huang, Liegang Liu, Weizhi Ji, Tianqing Li*. Neuroprotective Effects of 7, 8-dihydroxyflavone on Midbrain Dopaminergic Neurons in MPP+-treated Monkeys[J].Scientific Reports.6,34339 (2016),12 October 2016
    30. Zongyong Ai, Zheng Xiang, Yuemin Li, Guoku Liu, Hong Wang, Yun Zheng, Xiaoyan Qiu, Shumei Zhao, Xiaoqing Zhu, Yanhua Li*, Weizhi Ji, Tianqing Li*. Conversion of monkey fibroblasts to transplantable telencephalic neuroepithelial stem cells[J]. Biomaterials. Volume 77, January 2016, Pages 53-65.
    31. Hanlin Lu, Zhimei Yuan, Tao Tan, Junwen Wang, Juyong Zhang, Hui-Juan Luo, Yudong Xia, Weizhi Ji, Fei Gao*. Improved tagmentation-based whole-genome bisulfite sequencing for input DNA from less than 100 mammalian cells[J]. Epigenomics. Vol.7,No.1:47-56.17 Feb 2015
    32. Jinjuan Zhang, Tianjie Li, Weizhi Ji, Yang Yu*, Tao Tan*. Rho GDIalpha Modulates Rabbit Trophoblast Stem Cell Survival and Migration[J]. Biol Reprod. Volume 93, Issue 6, 144, 1-9, 01 December 2015
    33. Bin Jiang, Zhen Xiang, Zongyong Ai, Hong Wang, Yanjiao Li, Weizhi Ji*, Tianqing Li. Generation of cardiac spheres from primate pluripotent stem cells in a small molecule-based 3D system[J]. Biomaterials.Volume 65, October 2015, Pages 103-114.
    34. Yongchang Chen, Yinghui Zheng, Yu Kang, Weili Yang, Yuyu Niu, Xiangyu Guo, Zhuchi Tu, Chenyang Si, Hong Wang, Ruxiao Xing, Xiuqiong Pu, Shang-Hsun Yang, Shihua Li, Weizhi Ji, Xiao-Jiang Li*. Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9[J]. Hum Mol Genet. Volume 24, Issue 13, 1 July 2015, Pages 3764–3774. 09 April 2015
    35. Yongchang Chen, Yuyu Niu, Yanjiao Li, Zongyong Ai, Yu Kang, Hong Shi, Zheng Xiang, Zhaohui Yang, Tao Tan, Wei Si, Wei Li, Xueshan Xia, Qi Zhou*, Weizhi Ji, Tianqing Li. Generation of Cynomolgus Monkey Chimeric Fetuses using Embryonic Stem Cells[J]. Cell Stem Cell. Volume 17, Issue 1, 2 July 2015, Pages 116-124
    36. Yuyu Niu, Xiangyu Guo, Yongchang Chen, Chuan-En Wang, Jinquan Gao, Weili Yang, Yu Kang, Wei Si, Hong Wang, Shang-Hsun Yang, Shihua Li, Weizhi Ji*, Xiao-Jiang Li. Early Parkinson's disease symptoms in alpha-synuclein transgenic monkeys[J]. Hum Mol Genet. Volume 24, Issue 8, 15 April 2015, Pages 2308–2317,30 December 2014
    37. Haifeng Wan, Chunjing Feng, Fei Teng, Shihua Yang, Baoyang Hu, Yuyu Niu, Andy Peng Xiang, Weizhen Fang, Weizhi Ji, Wei Li, Xiaoyang Zhao, Qi Zhou*. One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system[J]. Cell Res. 25, 258–261 (2015),28 November 2014
    38. Yongchang Chen, Yiqiang Cui, Bin Shen, Yuyu Niu, Xiaoyang Zhao, Lei Wang, Jianying Wang, Wei Li, Qi Zhou, Weizhi Ji, Jiahao Sha, Xingxu Huang*. Germline acquisition of Cas9/RNA-mediated gene modifications in monkeys[J]. Cell Res. 25, 262–265 (2015),23 December 2014
    39. Yu Kang, Bo Zheng, Bin Shen, Yongchang Chen, Lei Wang, Jianying Wang, Yuyu Niu, Yiqiang Cui, Jiankui Zhou, Hong Wang, Xuejiang Guo, Bian Hu, Qi Zhou, Jiahao Sha, Weizhi Ji, Xingxu Huang.* CRISPR/Cas9-mediated Dax1 knockout in the monkey recapitulates human AHC-HH[J]. Hum Mol Genet. Volume 24, Issue 25, 20 December 2015, Pages 7255–7264
    40. Hong Wang, Tao Tan, Junfeng Wang, Yuyu Niu, Yaping Yan, Xiangyu Guo, Yu Kang, Yanchao Duan, Shaohui Chang, Jianpeng Liao, Chenyang Si, Weizhi Ji*, Wei Si. Rhesus monkey model of liver disease reflecting clinical disease progression and hepatic gene expression analysis[J]. Sci Rep. 5, 15019 (2015),07 October 2015
    41. Hailiang Liu, Yongchang Chen, Yuyu Niu, Kunshan Zhang, Yu Kang, Weihong Ge, Xiaojing Liu, Enfeng Zhao, Chencheng Wang, Shaoyun Lin, Bo Jing, Chenyang Si, Quan Lin, Xiaoying Chen, Haijun Lin, Xiuqiong Pu, Yingying Wang, Binlian Qin, Fang Wang, Hong Wang, Wei Si, Jing Zhou , Tao Tan, Tianqing Li, Shaohui Ji, Zhigang Xue, Yuping Luo, Liming Cheng, Qi Zhou, Siguang Li*, Yi Eve Sun, Weizhi Ji. TALEN-mediated gene mutagenesis in rhesus and cynomolgus monkeys[J]. Cell Stem Cell. Volume 14, Issue 3, 6 March 2014, Pages 323-328
    42. Yuyu Niu, Bin Shen, Yiqiang Cui, Yongchang Chen, Jianying Wang, Lei Wang, Yu Kang, Xiaoyang Zhao, Wei Si, Wei Li, Andy Peng Xiang, Jiankui Zhou, Xuejiang Guo, Ye Bi, Chenyang Si, Bian Hu, Guoying Dong, Hong Wang, Zuomin Zhou, Tianqing Li, Tao Tan, Xiuqiong Pu, Fang Wang, Shaohui Ji, Qi Zhou, Xingxu Huang*, Weizhi Ji*, Jiahao Sha*. Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos. Cell, Volume 156, Issue 4, 836-843, 30 January 2014
    43. Hailiang Liu, Yongchang Chen, Yuyu Niu, Kunshan Zhang, Yu Kang, Weihong Ge, Xiaojing Liu, Enfeng Zhao, Chencheng Wang, Shaoyun Lin, Bo Jing, Chenyang Si, Quan Lin, Xiaoying Chen, Haijun Lin, Xiuqiong Pu, Yingying Wang, Binlian Qin, Fang Wang, Hong Wang, Wei Si, Jing Zhou, Tao Tan, Tianqing Li, Shaohui Ji, Zhigang Xue, Yuping Luo, Liming Cheng, Qi Zhou, Siguang Li*, Yi Eve Sun*, Weizhi Ji*. TALEN-Mediated Gene Mutagenesis in Rhesus and Cynomolgus Monkeys. Cell Stem Cell, Volume 14, Issue 3, 323-328, 13 February 2014
    44. Yunfang Zhang, Ying Zhang, Junchao Shi, He Zhang, Zhonghong Cao, Xuan Gao, Wanhua Ren, Yunna Ning, Lina Ning, Yujing Cao, Yongchang Chen, Weizhi Ji, Zi-Jiang Chen, Qi Chen, Enkui Duan*. Identification and characterization of an ancient class of small RNAs enriched in serum associating with active infection[J]. J Mol Cell Biol. Volume 6, Issue 2, April 2014, Pages 172–174,30 December 2013
    45. Tao Tan, Bin Lu, Jing Zhang, Yuyu Niu, Wei Si, Qiang Wei, Weizhi Ji*. Notch1 signaling antagonizes transforming growth factor-beta pathway and induces apoptosis in rabbit trophoblast stem cells[J]. Stem Cells Dev. Volume: 23 Issue 8: November 19, 2013
    46. Tao Tan, Bin Lu, Jing Zhang, Yuyu Niu, Wei Si, Qiang Wei, Weizhi Ji* 2013 Notch1 Signaling Antagonizes Transforming Growth Factor-β Pathway and Induces Apoptosis in Rabbit Trophoblast Stem Cells. Stem Cells and Development.doi:1089/scd.2013.0280
    47. Yongchang Chen, Yuyu Niu, Weizhi Ji. 2012 Transgenic nonhuman primate models for human diseases: approaches and contributing factors. J Genet Genomics. 39(6):247-51.
    48. Yongchang Chen,Yuyu Niu,Shihua Yang,Xiechao He,Shaohui Ji,Wei Si,Xianghui Tang,Yunhua Xie,Hong Wang,Yongqing Lu,Qi Zhou, Weizhi Ji. 2012 The Available Time Window for Embryo Transfer in the Rhesus Monkey (Macaca mulatta). American Journal of Primatology. 74 (2):165–173
    49. Yongchang Chen 1, Zhengbo Wang, Yunhua Xie, Xiangyu Guo, Xianghui Tang, Shufen Wang, Shihua Yang, Kai Chen, Yuyu Niu, Weizhi Ji.2012Folic acid deficiency inhibits neural rosette formation and neuronal differentiation from rhesus monkey embryonic stem cells. J Neurosci Res. 90(7):1382-91
    50. Tao Tan 1, Xianghui Tang, Jing Zhang, Yuyu Niu, Hongwei Chen, Bin Li, Qiang Wei, Weizhi Ji. 2011 Generation of trophoblast stem cells from rabbit embryonic stem cells with BMP4. Plos One Volume 6 | Issue 2 | e17124.
    51. Shihua Yang 1, Shuhuang Ping, Wei Si, Xiechao He, Xinyi Wang, Yongqing Lu, Shaohui Ji, Yuyu Niu, Weizhi Ji. 2011 Optimization of ethylene glycol concentrations, freezing rates and holding times in liquid nitrogen vapor for cryopreservation of rhesus macaque (Macaca mulatta) sperm. J Vet Med Sci. 73(6):717-23.
    52. Shihua Yang 1, Shuhuang Ping, Shaohui Ji, Yongqing Lu, Yuyu Niu, Hong Wang, Weizhi Ji, Wei Si. 2011 The positive effects of seminal plasma during the freezing process on cryosurvival of sperm with poor freezability in the rhesus macaque (Macaca mulatta). J Reprod Dev. 57(6):737-43.
    53. Yuyu Niu , Yang Yu, Agnieszka Bernat, Shihua Yang, Xiechao He, Xiangyu Guo, Dongliang Chen, Yongchang Chen, Shaohui Ji, Wei Si, Yongqin Lv, Tao Tan, Qiang Wei, Hong Wang, Lei Shi, Jean Guan, Xuemei Zhu, Marielle Afanassieff, Pierre Savatier, Kang Zhang, Qi Zhou, Weizhi Ji. 2010 Transgenic rhesus monkeys produced by gene transfer into early cleavage stage embryos using a simian immunodeficiency virus-based vector. Proc Natl Acad Sci U S A. 12:107(41):17663-7.
    54. Yingying Wang, Tang Hai, Zichuan Liu, Shuya Zhou, Zhuo Lv, Chenhui Ding, Lei Liu, Yuyu Niu, Xiaoyang Zhao, Man Tong, Liu Wang, Alice Jouneau, Xun Zhang, Weizhi Ji, Qi Zhou. 2010 HSPC117 deficiency in clonedembryos causes placental abnormality and fetal death. Biochem Biophys Res Commun. 397(3):407-12.
    55. Hongwei Chen, Qiang Wei, Jing Zhang, Chuangkun Xu, Tao Tan, Weizhi Ji. 2010 Netrin-1 signaling mediates O-induced glial precursor migration and accumulation. Cell Research advance online publication 19 January 2010; doi: 10.1038/cr.2010.7
    56. Xinjie Chen, Tianqing Li, Xuemei Li, Yunhua Xie, Xiangyu Guo, Shaohui Ji, Yiyu Niu, Yang Yu, Chenhui Ding, Ruqiang Yao, Shihua Yang, Weizhi Ji, Qi Zhou, Zhou Q 2009 Neural progenitors derived from monkey embryonic stem cells in a simple monoculture system. Reproductive BioMedicine 19: 426-433.
    57. Guangwen Ren 1, Juanjuan Su, Liying Zhang, Xin Zhao, Weifang Ling, Andrew L'huillie, Jimin Zhang, Yongqing Lu, Arthur I Roberts, Weizhi Ji, Huatang Zhang, Arnold B Rabson, Yufang Shi. 2009 Species variation in the mechanisms of mesenchymal stem cell-mediated immunosuppression. Stem Cells. 27(8):1954-62.
    58. Lifang Jin, Shaohui Ji, Xianghui Tang, Xiangyu Guo, Yongqing Lu, Hongwei Chen, Hongkui Deng, Qi Zhou, Weizhi Ji. 2009 Isolation and characterization of liver epithelial progenitor cells from normal adult rhesus monkeys (Macaca mulatta). Cell Research 19:268-270.
    59. Yang S, He X, Niu Y, Hildebrandt TB, Jewgenow K, Goeritz F, Tang X, Chang Y, Zhou Q, Ji W. 2009 Ovarian response to gonadotropin stimulation in juvenile rhesus monkeys. Theriogenology 72: 243-50.
    60. Li Jun#,Li nan#, Jingkuan Wei#,Feng chun,Yanying Chen,Tingwei Chen,Zongyong Ai,Xiaoqing Zhu,Weizhi Ji*,Tianqing Li*. Genetically engineered mesenchymal stem cells with dopamine synthesis for Parkinson’s disease in animal models. npj Parkinson’s Disease, 2022.12. 2022 Dec 22;8(1):175. [IF: 9.3]
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