- 赵璐 (Lu Zhao)博士、副教授
硕士研究生导师Ph.D, Associate Professor
E-mail: zhaol@lpbr.cn
一、受教育及工作经历 (Education and Work Experience)
- 2000年9月―2005年7月， 中山大学医学院（原中山医科大学），获医学学士学位。
- 2005年9月―2012年1月， 中国科学院遗传与发育生物学研究所，分子发育生物学国家重点实验室，发育生物学专业，获博士学位
- 2012年1月—2015年1月，中国科学院遗传与发育生物学研究所，分子发育生物学国家重点实验室，博士后
- 2015年1月—2018年1月，英国剑桥大学遗传学系，博士后
- 2018年4月至今，昆明理工大学灵长类转化医学研究院，副教授
- Sep 2000- Jul 2005 B.S. in Preventive Medicine, School of Public Health, Sun Yat-sen University of Medical Science, Guangzhou, China
- Sep 2005- Jan 2012 Ph.D.in Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
- Jan 2012- Jan 2015 Postdoctoral Researcher, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
- Jan 2015- Jan2018 Research Associated, Development of Genetics, University of Cambridge, Cambridge, UK
- Apr 2018-presentAssociated Professor, The Yunnan Key Laboratory of Primate Biomedical Research (LPBR), Institute of Primate Translational Medicine, Kunming University of Science and Technology (KUST), Kunming, China
二、主要研究方向 (Research Interests)
- 神经系统的发育与功能
- 神经退行性疾病的分子机制与基因治疗
- The development and function of the nervous system
- Molecular mechanism and gene therapy of neurodegenerative diseases
三、科研领域描述 (Description of the Research)
神经元结构和功能的完整是维持神经系统正常生理功能的前提。神经元的损伤或丢失会导致包括阿茨海默症（AD）、帕金森症（PD）、肌萎缩侧索硬化症（ALS）在内的多种神经退行性疾病。在世界范围内，这一类疾病都造成了巨大的社会经济负担。然而遗憾的是，目前我们对神经退行性疾病的发病机制并没有全面深入的认识，亦没有有效的治愈手段。得益于靶向基因编辑技术的革命性进展，我们得以利用与人类在基因组序列和神经系统结构等方面都高度相似的灵长类动物构建神经退行性疾病模型，综合运用分子生物学、电生理学、功能性成像、行为学等多学科技术手段，对疾病的发病机理进行研究，探索可靠的早期诊断指标以及有效的治疗手段。
The integrity of neuronal structure and function is a prerequisite for maintaining normal physiological operations of the nervous system. Damage or loss of neurons leads to a range of neurodegenerative disorders, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS). Worldwide, such diseases impose a substantial socio-economic burden. Regrettably, however, we still lack a comprehensive and in-depth understanding of their pathogenic mechanisms, and no effective cure is currently available.
Thanks to revolutionary advances in targeted gene-editing technology, we are now able to establish neurodegenerative disease models using non-human primates, which share high genomic similarity and comparable neurological structures with humans. By integrating multidisciplinary approaches—including molecular biology, electrophysiology, functional imaging, and behavioural analysis—we can investigate disease mechanisms, identify reliable early diagnostic markers, and explore effective therapeutic strategies.
四、承担及参与科研项目情况 (Research Projects and Grants)
1. 国家自然科学基金委青年科学基金项目，主持。
2. 欧盟 Marie Skłodowska-Curie Individual Fellowship，主持。
3. 国家基金委-地区基金，主持。
4. 云南省“兴滇英才”青年人才项目，主持
五、代表性论文和专著(Publications)
1. Wei J, Li S, Duan D, Wu K, Liu X, Zhu R, Wang L, Wu Z, Kang Y, Si C, Zhang H, Wang H, Chen Y, Dai S, Ji W, Li G, Zhao L, Niu Y (2026) alpha-Synuclein aggregation and brain atrophy in SNCA-A53T transgenic monkeys correlate with parkinsonism. Brain. doi:10.1093/brain/awag046
2. Shen J, Li Y, Bian N, Yang L, Pan Y, Niu Y, Zhao L, Zhang L, Wei J (2025) Photocuring CsA and bFGF-embedded hemostatic hydrogel promotes recovery from TBI by mitigating ferroptosis and neuroinflammation. iScience 28:112865. doi:10.1016/j.isci.2025.112865
3. Si C, Zhu R, Wu J, Chen Z, Tang Z, Li Z, Kang Y, Xiang L, Zuo J, Yang P, Chu C, Yang S, Li Z, Zhao L, Chen X, Pu Y, Tian B, Yang Z, Ji W, Dai S, Niu Y (2025) Production of live monkeys and their genetically matched embryonic stem cells from single embryos. Nat Commun 16:5529. doi:10.1038/s41467-025-60694-5
4. Luo X, Jia H, Wang F, Mo H, Kang Y, Zhang N, Zhao L, Xu L, Yang Z, Yang Q, Chang Y, Li S, Bian N, Hua X, Cui H, Cao Y, Chu C, Zeng Y, Chen X, Chen Z, Ji W, Long C, Song J, Niu Y (2024) Primate Model Carrying LMNA Mutation Develops Dilated Cardiomyopathy. JACC Basic Transl Sci 9:380-395. doi:10.1016/j.jacbts.2023.11.002
5. Shen J, Bian N, Zhao L, Wei J (2024) The role of T-lymphocytes in central nervous system diseases. Brain Res Bull 209:110904. doi:10.1016/j.brainresbull.2024.110904
6. Xu L, Wang D, Zhao L, Yang Z, Liu X, Li X, Yuan T, Wang Y, Huang T, Bian N, He Y, Chen X, Tian B, Liu Z, Luo F, Si W, Gao G, Ji W, Niu Y, Wei J (2023) C9orf72 poly(PR) aggregation in nucleus induces ALS/FTD-related neurodegeneration in cynomolgus monkeys. Neurobiol Dis 184:106197. doi:10.1016/j.nbd.2023.106197
7. Hong H, Zhao K, Huang S, Huang S, Yao A, Jiang Y, Sigrist S, Zhao L, Zhang YQ (2020) Structural Remodeling of Active Zones Is Associated with Synaptic Homeostasis. J Neurosci 40:2817-2827. doi:10.1523/JNEUROSCI.2002-19.2020
8. Zhao K, Hong H, Zhao L, Huang S, Gao Y, Metwally E, Jiang Y, Sigrist SJ, Zhang YQ (2020) Postsynaptic cAMP signalling regulates the antagonistic balance of Drosophila glutamate receptor subtypes. Development 147. doi:10.1242/dev.191874
9. Niu Y, Sun N, Li C, Lei Y, Huang Z, Wu J, Si C, Dai X, Liu C, Wei J, Liu L, Feng S, Kang Y, Si W, Wang H, Zhang E, Zhao L, Li Z, Luo X, Cui G, Peng G, Izpisua Belmonte JC, Ji W, Tan T (2019) Dissecting primate early post-implantation development using long-term in vitro embryo culture. Science 366. doi:10.1126/science.aaw5754
10. Yalcin B, Zhao L, Stofanko M, O'Sullivan NC, Kang ZH, Roost A, Thomas MR, Zaessinger S, Blard O, Patto AL, Sohail A, Baena V, Terasaki M, O'Kane CJ (2017) Modeling of axonal endoplasmic reticulum network by spastic paraplegia proteins. Elife 6. doi:10.7554/eLife.23882
11. Jiang F, Lu F, Li P, Liu W, Zhao L, Wang Q, Cao X, Zhang L, Zhang YQ (2016) Drosophila Homolog of FMRP Maintains Genome Integrity by Interacting with Piwi. J Genet Genomics 43:11-24. doi:10.1016/j.jgg.2015.11.001
12. Zhao L, Wang D, Wang Q, Rodal AA, Zhang YQ (2013) Drosophila cyfip regulates synaptic development and endocytosis by suppressing filamentous actin assembly. PLoS Genet 9:e1003450. doi:10.1371/journal.pgen.1003450
六、招生与招聘
欢迎优秀的本科生报考实验室的硕士研究生。要求获得本科及以上学历，具有独立研究工作能力和合作精神，善于交流，有良好的文字表达能力和协调沟通能力。
有意者请发送简历至zhaol@lpbr.cn。
